Institut für Klinische Pathologie

• Mechanismen der Epithelial-Mesenchymalen-Transition
• Tumor-Stroma-Interaktionen
• Dreidimensionale Rekonstruktionen solider Tumoren
• miRNA Expressionsmuster solider Tumoren

• Dreidimensionale Rekonstruktion solider Tumoren
• MALDI Imaging

PD Dr. Peter Bronsert
Institute of Pathology
University Hospital Freiburg
Breisacher Strasse 115a
D-79106 Freiburg
Germany

Tel:  +49 761 270 80590
Fax: +49 761 270 81970 
peter.bronsert@uniklinik-freiburg.de

Erst und Letztautorenschaften (* geteilte Autorenschaft)

2023

1. Steybe D, Poxleitner P, Metzger MC, Rothweiler R, Beck J, Straehle J, Vach K, Weber A, Enderle-Ammour K, Werner M, Schmelzeisen R, Bronsert P. Stimulated Raman histology for histological evaluation of oral squamous cell carcinoma. Clin Oral Investig. 2023 Jun 22. doi: 10.1007/s00784-023-05098-9. Epub ahead of print. PMID: 37349642.

2. Kocsmár É, Schmid M, Cosenza-Contreras M, Kocsmár I, Föll M, Krey L, Barta BA, Rácz G, Kiss A, Werner M, Schilling O, Lotz G, Bronsert P*. Proteome alterations in human autopsy tissues in relation to time after death. Cell Mol Life Sci. 2023 Apr 5;80(5):117. doi: 10.1007/s00018-023-04754-3. PMID: 37020120; PMCID: PMC10075177.

2022

1. Lüchtenborg AM, Metzger P, Cosenza Contreras M, Oria V, Biniossek ML, Lindner F, Fröhlich K, Malyi A, Erbes T, Gensch N, Maurer J, Thomsen A, Boerries M, Schilling O, Werner M, Bronsert P. Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer. Breast Cancer Res. 2022 Oct 3;24(1):65. doi: 10.1186/s13058-022-01562-8. PMID: 36192788; PMCID: PMC9531505.

2. Budau KL, Sigel CS, Bergmann L, Lüchtenborg AM, Wellner U, Schilling O, Werner M, Tang L, Bronsert P. Prognostic Impact of Tumor Budding in Intrahepatic Cholangiocellular Carcinoma. J Cancer. 2022 May 6;13(8):2457-2471. doi: 10.7150/jca.63008. PMID: 35711834; PMCID: PMC9174844.

2. Föll MC, Volkmann V, Enderle-Ammour K, Timme S, Wilhelm K, Guo D, Vitek O, Bronsert P*, Schilling O. Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: a case study of an urothelial cancer cohort analyzed in the Galaxy framework. Clin Proteomics. 2022 Apr 19;19(1):8. doi: 10.1186/s12014-022-09347-z. PMID: 35439943; PMCID: PMC9016955.

2021

1. Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol. von Schoenfeld A, Bronsert P, Poc M, Fuller A, Filby A, Kraft S, Kurowski K, Sörensen K, Huber J, Pfeiffer J, Proietti M, Stehl V, Werner M, Seidl M. Int J Mol Sci. 2021 Dec 25;23(1):223. doi: 10.3390/ijms23010223. PMID: 35008649

2020

1. Prognostic impact of tumor budding and EMT in periampullary adenocarcinoma: a quantitative approach. Kocsmár É, Lotz G, Kiss A, Hoerner M, Petrova E, Freudenberg N, Csanádi Á, Kulemann B, Werner M, Bronsert P, Wellner UF. J Cancer. 2020 Sep 17;11(22):6474-6483. doi: 10.7150/jca.46093. eCollection 2020. PMID: 33046968

2. High Numbers and Densities of PD1+ T-Follicular Helper Cells in Triple-Negative Breast Cancer Draining Lymph Nodes Are Associated with Lower Survival. Bronsert P, von Schoenfeld A, Villacorta Hidalgo J, Kraft S, Pfeiffer J, Erbes T, Werner M, Seidl M. Int J Mol Sci. 2020 Aug 19;21(17):5948. doi: 10.3390/ijms21175948. PMID: 32824917

2018

1. Loss of PSMA Expression in Non-neuroendocrine Dedifferentiated Acinar Prostate Cancer. Bronsert P, Reichel K, Ruf J. Clin Nucl Med. 2018 Jul;43(7):526-528. doi: 10.1097/RLU.0000000000002100.

2. Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype. Seidl M, Bader M, Vaihinger A, Wellner UF, Todorova R, Herde B, Schrenk K, Maurer J, Schilling O, Erbes T, Fisch P, Pfeiffer J, Hoffmann L, Franke K, Werner M, Bronsert P. Sci Rep. 2018 Mar 28;8(1):5321. doi: 10.1038/s41598-018-23629-3.

2017

1. The Role of Fibroblasts in Pancreatic Cancer: Extracellular Matrix Versus Paracrine Factors. Bolm L, Cigolla S, Wittel UA, Hopt UT, Keck T, Rades D, Bronsert P*, Wellner UF. Transl Oncol. 2017 Jun 25;10(4):578-588. doi: 10.1016/j.tranon.2017.04.009.

2. Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds. Enderle-Ammour K, Bader M, Ahrens TD, Franke K, Timme S, Csanadi A, Hoeppner J, Kulemann B, Maurer J, Reiss P, Schilling O, Keck T, Brabletz T, Stickeler E, Werner M, Wellner UF, Bronsert P. Tumour Biol. 2017 May;39(5):1010428317705501. doi:10.1177/1010428317705501.

3. The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study. Fuellgraf H, Schilling O, Lai ZW, Kulemann B, Timme S, Makowiec F, Shahinian JH, Hoeppner J, Werner M, Hopt UT, Wellner UF, Bronsert P*. J Cancer. 2017 Feb 25;8(4):657-664. doi: 10.7150/jca.16200. eCollection 2017.

2016

1. Histopathological tumor invasion of the mesenterico-portal vein is characterized by aggressive biology and stromal fibroblast activation. Lapshyn H, Bolm L, Kohler I, Werner M, Billmann FG, Bausch D, Hopt UT, Makowiec F, Wittel UA, Keck T, Bronsert P*, Wellner UF. HPB (Oxford). 2017 Jan;19(1):67-74. doi: 10.1016/j.hpb.2016.10.002. Epub 2016 Nov 5.

2. Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses. Lai ZW, Bolm L, Fuellgraf H, Biniossek ML, Makowiec F, Hopt UT, Werner M, Keck T, Bausch D, Sorio C, Scarpa A, Schilling O, Bronsert P, Wellner UF. BMC Cancer. 2016 Mar 8;16(1):195. doi: 10.1186/s12885-016-2193-5.

3. Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study. Wellner UF, Krauss T, Csanadi A, Lapshyn H, Bolm L, Timme S, Kulemann B, Hoeppner J, Kuesters S, Seifert G, Bausch D, Schilling O, Vashist YK, Bruckner T, Langer M, Makowiec F, Hopt UT, Werner M, Keck T, Bronsert P. Medicine (Baltimore). 2016 Jan;95(3):e2529. doi: 10.1097/MD.0000000000002529.

4. Prognostic factors after pancreatoduodenectomy with en bloc portal venous resection for pancreatic cancer. Lapshyn H, Bronsert P, Bolm L, Werner M, Hopt UT, Makowiec F, Wittel UA, Keck T, Wellner UF, Bausch D. Langenbecks Arch Surg. 2016 Feb;401(1):63-9. doi: 10.1007/s00423-015-1363-2. Epub 2016 Jan 6.

2014

1. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface. Bronsert P, Enderle-Ammour K, Bader M, Timme S, Kuehs M, Csanadi A, Kayser G, Kohler I, Bausch D, Hoeppner J, Hopt UT, Keck T, Stickeler E, Passlick B, Schilling O, Reiss CP, Vashist Y, Brabletz T, Berger J, Lotz J, Olesch J, Werner M, Wellner UF. J Pathol. 2014 Nov;234(3):410-22. doi: 10.1002/path.4416

2. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer. Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF. Surgery. 2014 Jul;156(1):97-108. doi: 10.1016/j.surg.2014.02.018.

3. Impact of routinely employed procedures for tissue processing on the proteomic analysis of formalin-fixed paraffin-embedded tissue. Bronsert P, Weißer J, Biniossek ML, Kuehs M, Mayer B, Drendel V, Timme S, Shahinian H, Küsters S, Wellner UF, Lassmann S, Werner M, Schilling O. Proteomics Clin Appl. 2014 Oct;8(9-10):796-804. doi: 10.1002/prca.201300082.

2013

1. Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin. Bronsert P, Kohler I, Werner M, Makowiec F, Kuesters S, Hoeppner J, Hopt UT, Keck T, Bausch D, Wellner UF. BMC Cancer. 2013 Sep 22;13:428. doi: 10.1186/1471-2407-13-428.

Co-Autorenschaften 

2023

1. Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer. Lombaers MS, Cornel KMC, Visser NCM, Bulten J, Küsters-Vandevelde HVN, Amant F, Boll D, Bronsert P, Colas E, Geomini PMAJ, Gil-Moreno A, van Hamont D, Huvila J, Krakstad C, Kraayenbrink AA, Koskas M, Mancebo G, Matías-Guiu X, Ngo H, Pijlman BM, Vos MC, Weinberger V, Snijders MPLM, van Koeverden SW, Enitec-Consortium, Haldorsen IS, Reijnen C, Pijnenborg JMA. Cancers (Basel). 2023 May 4;15(9):2605. doi: 10.3390/cancers15092605. PMID: 37174070 Free PMC article.

2. Raman Spectroscopic Imaging of Human Bladder Resectates towards Intraoperative Cancer Assessment. Krafft C, Popp J, Bronsert P, Miernik A. Cancers (Basel). 2023 Apr 5;15(7):2162. doi: 10.3390/cancers15072162. PMID: 37046822 Free PMC article.

3. Proteome alterations in human autopsy tissues in relation to time after death. Kocsmár É, Schmid M, Cosenza-Contreras M, Kocsmár I, Föll M, Krey L, Barta BA, Rácz G, Kiss A, Werner M, Schilling O, Lotz G, Bronsert P. Cell Mol Life Sci. 2023 Apr 5;80(5):117. doi: 10.1007/s00018-023-04754-3. PMID: 37020120 Free PMC article.

4. Dermatofibrosarcoma protuberans of the scalp: Surgical management in a multicentric series of 11 cases and systematic review of the literature. Kuhlmann C, Ehrl D, Taha S, Wachtel N, Schmid A, Bronsert P, Zeller J, Giunta RE, Eisenhardt SU, Braig D. Surgery. 2023 Apr 1:S0039-6060(23)00115-0. doi: 10.1016/j.surg.2023.02.026. Online ahead of print. PMID: 37012145

5. Multiparametric magnetic resonance imaging for radiation therapy response monitoring in soft tissue sarcomas: a histology and MRI co-registration algorithm. Jung M, Bogner B, Diallo TD, Kim S, Arnold P, Füllgraf H, Kurowski K, Bronsert P, Jungmann PM, Kiefer J, Kraus D, Rovedo P, Reisert M, Eisenhardt SU, Bamberg F, Benndorf M, Runkel A. Theranostics. 2023 Mar 5;13(5):1594-1606. doi: 10.7150/thno.81938. eCollection 2023. PMID: 37056570 Free PMC article.

6. Correction to: Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection. Dörflinger B, Badr MT, Haimovici A, Fischer L, Vier J, Metz A, Eisele B, Bronsert P, Aumann K, Höppner J, Waguia Kontchou C, Parui I, Weber A, Kirschnek S, Häcker G. Cell Death Differ. 2023 Mar;30(3):854. doi: 10.1038/s41418-022-01019-7. PMID: 35577976 Free PMC article. No abstract available.

7. Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling. Werner J, Bernhard P, Cosenza-Contreras M, Pinter N, Fahrner M, Pallavi P, Eberhard J, Bronsert P, Rückert F, Schilling O. Neoplasia. 2023 Feb;36:100871. doi: 10.1016/j.neo.2022.100871. Epub 2023 Jan 5. PMID: 36610378

2022

1. Genomic classifiers in personalized prostate cancer radiotherapy approaches - a systematic review and future perspectives based on international consensus. Spohn SKB, Draulans C, Kishan AU, Spratt D, Ross A, Maurer T, Tilki D, Berlin A, Blanchard P, Collins S, Bronsert P, Chen R, Pra AD, de Meerleer G, Eade T, Haustermans K, Hölscher T, Höcht S, Ghadjar P, Davicioni E, Heck M, Kerkmeijer LGW, Kirste S, Tselis N, Tran PT, Pinkawa M, Pommier P, Deltas C, Schmidt-Hegemann NS, Wiegel T, Zilli T, Tree AC, Qiu X, Murthy V, Epstein JI, Graztke C, Gao X, Grosu AL, Kamran SC, Zamboglou C. Int J Radiat Oncol Biol Phys. 2022 Dec 31:S0360-3016(22)03691-4. doi: 10.1016/j.ijrobp.2022.12.038. PMID: 36596346 Review.

2. Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens. Neubauer C, Yilmaz JS, Bronsert P, Pichotka M, Bamberg F, Windfuhr-Blum M, Erbes T, Neubauer J. Sci Rep. 2022 Oct 21;12(1):17639. doi: 10.1038/s41598-022-21616-3. PMID: 36271228

3. Individualized Mini-Panel Sequencing of ctDNA Allows Tumor Monitoring in Complex Karyotype Sarcomas. Braig D, Runkel A, Eisenhardt AE, Schmid A, Zeller J, Pauli T, Lausch U, Wehrle J, Bronsert P, Jung M, Kiefer J, Boerries M, Eisenhardt SU. Int J Mol Sci. 2022 Sep 6;23(18):10215. doi: 10.3390/ijms231810215. PMID: 36142126

4. Quantitative Analysis of Diffusion Weighted Imaging May Improve Risk Stratification of Prostatic Transition Zone Lesions.  Engel H, Oerther B, Reisert M, Kellner E, Sigle A, Gratzke C, Bronsert P, Krauss T, Bamberg F, Benndorf M. In Vivo. 2022 Sep-Oct;36(5):2323-2331. doi: 10.21873/invivo.12963. PMID: 36099133

5. Clinical Outcome and Prognostic Factors of Pancreatic Adenosquamous Carcinoma Compared to Ductal Adenocarcinoma-Results from the German Cancer Registry Group. Braun R, Klinkhammer-Schalke M, Zeissig SR, Kleihus van Tol K, Bolm L, Honselmann KC, Petrova E, Lapshyn H, Deichmann S, Abdalla TSA, Heckelmann B, Bronsert P, Zemskov S, Hummel R, Keck T, Wellner UF. Cancers (Basel). 2022 Aug 16;14(16):3946. doi: 10.3390/cancers14163946. PMID: 36010939

6. Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients. Marinescu IM, Spohn SKB, Kiefer S, Bronsert P, Ceci L, Holzschuh J, Sigle A, Jilg CA, Rühle A, Sprave T, Nicolay NH, Winzer R, Rehm J, Kotzerke J, Hölscher T, Grosu AL, Ruf J, Benndorf M, Zamboglou C. Front Oncol. 2022 Jul 14;12:880042. doi: 10.3389/fonc.2022.880042. eCollection 2022. PMID: 35912219

7. Human Mesenchymal Stromal Cells Do Not Cause Radioprotection of Head-and-Neck Squamous Cell Carcinoma. Rühle A, Lies M, Strack M, Perez RL, Bieber B, Thomsen AR, Bronsert P, Huber PE, Hess J, Knopf A, Wuchter P, Grosu AL, Nicolay NH. Int J Mol Sci. 2022 Jul 12;23(14):7689. doi: 10.3390/ijms23147689. PMID: 35887032

8. Correction to: Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection. Dörflinger B, Badr MT, Haimovici A, Fischer L, Vier J, Metz A, Eisele B, Bronsert P, Aumann K, Höppner J, Waguia Kontchou C, Parui I, Weber A, Kirschnek S, Häcker G. Cell Death Differ. 2022 May 16. doi: 10.1038/s41418-022-01019-7. PMID: 35577976

9. Genotyping of Circulating Free DNA Enables Monitoring of Tumor Dynamics in Synovial Sarcomas. Eisenhardt AE, Brugger Z, Lausch U, Kiefer J, Zeller J, Runkel A, Schmid A, Bronsert P, Wehrle J, Leithner A, Liegl-Atzwanger B, Giunta RE, Eisenhardt SU, Braig D. Cancers (Basel). 2022 Apr 21;14(9):2078. doi: 10.3390/cancers14092078. PMID: 35565213

10. Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity. Fröhlich K, Brombacher E, Fahrner M, Vogele D, Kook L, Pinter N, Bronsert P, Timme-Bronsert S, Schmidt A, Bärenfaller K, Kreutz C, Schilling O. Nat Commun. 2022 May 12;13(1):2622. doi: 10.1038/s41467-022-30094-0. PMID: 35551187

11. Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection.  Dörflinger B, Badr MT, Haimovici A, Fischer L, Vier J, Metz A, Eisele B, Bronsert P, Aumann K, Höppner J, Waguia Kontchou C, Parui I, Weber A, Kirschnek S, Häcker G. Cell Death Differ. 2022 Nov;29(11):2218-2232. doi: 10.1038/s41418-022-01009-9. Epub 2022 May 3. PMID: 35505004

12. Moving translational mass spectrometry imaging towards transparent and reproducible data analyses: a case study of an urothelial cancer cohort analyzed in the Galaxy framework.  Föll MC, Volkmann V, Enderle-Ammour K, Timme S, Wilhelm K, Guo D, Vitek O, Bronsert P, Schilling O. Clin Proteomics. 2022 Apr 19;19(1):8. doi: 10.1186/s12014-022-09347-z. PMID: 35439943

13. Overexpression of integrin alpha 2 (ITGA2) correlates with poor survival in patients with pancreatic ductal adenocarcinoma. Deichmann S, Schindel L, Braun R, Bolm L, Taylor M, Deshpande V, Schilling O, Bronsert P, Keck T, Ferrone C, Wellner U, Honselmann K. J Clin Pathol. 2022 Apr 8:jclinpath-2022-208176. doi: 10.1136/jclinpath-2022-208176. PMID: 35396216

14. Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse. Haimovici A, Höfer C, Badr MT, Bavafaye Haghighi E, Amer T, Boerries M, Bronsert P, Glavynskyi I, Fanfone D, Ichim G, Thilmany N, Weber A, Brummer T, Spohr C, Öllinger R, Janssen KP, Rad R, Häcker G. Cell Death Dis. 2022 Apr 7;13(4):315. doi: 10.1038/s41419-022-04768-y. PMID: 35393399

15. T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D'Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B. J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1. PMID: 35367533

16. Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas. Eisenhardt AE, Schmid A, Esser J, Brugger Z, Lausch U, Kiefer J, Braig M, Runkel A, Wehrle J, Claus R, Bronsert P, Leithner A, Liegl-Atzwanger B, Zeller J, Papini R, von Laffert M, Pfitzner BM, Koulaxouzidis G, Giunta RE, Eisenhardt SU, Braig D. Mol Cancer. 2022 Feb 14;21(1):50. doi: 10.1186/s12943-022-01523-x. PMID: 35164780

17. Expression of Prostate Specific Membrane Antigen (PSMA) in Breast Cancer.  Unger C, Bronsert P, Michalski K, Bicker A, Juhasz-Böss I. Geburtshilfe Frauenheilkd. 2022 Jan 10;82(1):50-58. doi: 10.1055/a-1638-9429. eCollection 2022 Jan. PMID: 35027860

18. Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer. Waldeck S, Mitschke J, Wiesemann S, Rassner M, Andrieux G, Deuter M, Mutter J, Lüchtenborg AM, Kottmann D, Titze L, Zeisel C, Jolic M, Philipp U, Lassmann S, Bronsert P, Greil C, Rawluk J, Becker H, Isbell L, Müller A, Doostkam S, Passlick B, Börries M, Duyster J, Wehrle J, Scherer F, von Bubnoff N. Mol Oncol. 2022 Jan;16(2):527-537. doi: 10.1002/1878-0261.13116. Epub 2021 Oct 31. PMID: 34653314

2021

1. Petrova E, Wellner J, Nording AK, Braun R, Honselmann KC, Bolm L, Hummel R, Klinkhammer-Schalke M, Zeissig SR, Kleihues van Tol K, Timme-Bronsert S, Bronsert P, Zemskov S, Keck T, Wellner UF. Survival Outcome and Prognostic Factors for Pancreatic Acinar Cell Carcinoma: Retrospective Analysis from the German Cancer Registry Group. Cancers (Basel). 2021 Dec 4;13(23):6121. doi: 10.3390/cancers13236121. PMID: 34885230.

2. Fahrner M, Bronsert P, Fichtner-Feigl S, Jud A, Schilling O. Proteome biology of primary colorectal carcinoma and corresponding liver metastases. Neoplasia. 2021 Dec;23(12):1240-1251. doi: 10.1016/j.neo.2021.10.005. Epub 2021 Nov 9. PMID: 34768110; PMCID: PMC8591399.

3. Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Kirste S, Jacobasch L, Allgäuer M, Flentje M, Germer CT, Grützmann R, Hildebrandt G, Schwarzbach M, Bechstein WO, Sülberg H, Friede T, Gaedcke J, Ghadimi M, Hofheinz RD, Rödel C; German Rectal Cancer Study Group. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol. 2021 Nov 18:e215445. doi: 10.1001/jamaoncol.2021.5445. Epub ahead of print. PMID: 34792531; PMCID: PMC8603234.

4. Grünwald BT, Devisme A, Andrieux G, Vyas F, Aliar K, McCloskey CW, Macklin A, Jang GH, Denroche R, Romero JM, Bavi P, Bronsert P, Notta F, O'Kane G, Wilson J, Knox J, Tamblyn L, Udaskin M, Radulovich N, Fischer SE, Boerries M, Gallinger S, Kislinger T, Khokha R. Spatially confined sub-tumor microenvironments in pancreatic cancer. Cell. 2021 Oct 28;184(22):5577-5592.e18. doi: 10.1016/j.cell.2021.09.022. Epub 2021 Oct 12. PMID: 34644529.

5. Waldeck S, Mitschke J, Wiesemann S, Rassner M, Andrieux G, Deuter M, Mutter J, Lüchtenborg AM, Kottmann D, Titze L, Zeisel C, Jolic M, Philipp U, Lassmann S, Bronsert P, Greil C, Rawluk J, Becker H, Isbell L, Müller A, Doostkam S, Passlick B, Börries M, Duyster J, Wehrle J, Scherer F, von Bubnoff N. Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer. Mol Oncol. 2021 Oct 15. doi: 10.1002/1878-0261.13116. Epub ahead of print. PMID: 34653314.

6. Rühle A, Ping D, Lopez Perez R, Strack M, Brons S, Yijia Q, Debus J, Wuchter P, Grosu AL, Huber PE, Nicolay NH. Human mesenchymal stromal cells maintain their stem cell traits after high-LET particle irradiation - Potential implications for particle radiotherapy and manned space missions. Cancer Lett. 2022 Jan 1;524:172-181. doi: 10.1016/j.canlet.2021.10.015. Epub 2021 Oct 21. PMID: 34688844.

7. Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis. Braun R, Lapshyna O, Eckelmann S, Honselmann K, Bolm L, Ten Winkel M, Deichmann S, Schilling O, Kruse C, Keck T, Wellner U, Bronsert P, Brandenburger M. J Vis Exp. 2021 Jun 22;(172). doi: 10.3791/62541. PMID: 34251366

8. Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma. Rennert C, Tauber C, Fehrenbach P, Heim K, Bettinger D, Sogukpinar Ö, Schuch A, Zecher BF, Bengsch B, Lang SA, Bronsert P, Björkström NK, Fichtner-Feigl S, Schultheiss M, Thimme R, Hofmann M. Cells. 2021 Jun 2;10(6):1369. doi: 10.3390/cells10061369. PMID: 34199483 Free PMC article.

9. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Schwabenland M, Salié H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Püschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B. Immunity. 2021 Jun 9:S1074-7613(21)00246-6. doi: 10.1016/j.immuni.2021.06.002. Online ahead of print. PMID: 34174183 Free PMC article.

10. Influence of Urethra Sparing on Tumor Control Probability and Normal Tissue Complication Probability in Focal Dose Escalated Hypofractionated Radiotherapy: A Planning Study Based on Histopathology Reference. Spohn SKB, Sachpazidis I, Wiehle R, Thomann B, Sigle A, Bronsert P, Ruf J, Benndorf M, Nicolay NH, Sprave T, Grosu AL, Baltas D, Zamboglou C. Front Oncol. 2021 May 14;11:652678. doi: 10.3389/fonc.2021.652678. eCollection 2021. PMID: 34055621 Free PMC article.

11. Alteration of Tissue Marking Dyes Depends on Used Chromogen during Immunohistochemistry. Kiefer S, Huber J, Füllgraf H, Sörensen K, Csanadi A, Stillger MN, Werner M, Schaefer HE, Bronsert P, Aumann K. Cells. 2021 Apr 8;10(4):835. doi: 10.3390/cells10040835. PMID: 33917667 Free PMC article.

12. Surgeon vs Pathologist for Prediction of Pancreatic Fistula: Results from the Randomized Multicenter RECOPANC Study. Timme S, Kayser G, Werner M, Litkevych S, Màlyi AG, Keck T, Bronsert P, Wellner UF, Petrova E, Honselmann KC; RECOPANC Review Group. J Am Coll Surg. 2021 Jun;232(6):935-945.e2. doi: 10.1016/j.jamcollsurg.2021.03.024. Epub 2021 Apr 19. PMID: 33887486

13. The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer. Zamboglou C, Kramer M, Kiefer S, Bronsert P, Ceci L, Sigle A, Schultze-Seemann W, Jilg CA, Sprave T, Fassbender TF, Nicolay NH, Ruf J, Benndorf M, Grosu AL, Spohn SKB. Sci Rep. 2021 Mar 12;11(1):5836. doi: 10.1038/s41598-021-85028-5. PMID: 33712662 Free PMC article.

14. Human Primary Breast Cancer Stem Cells Are Characterized by Epithelial-Mesenchymal Plasticity. Strietz J, Stepputtis SS, Follo M, Bronsert P, Stickeler E, Maurer J. Int J Mol Sci. 2021 Feb 11;22(4):1808. doi: 10.3390/ijms22041808. PMID: 33670400 Free PMC article.

2020

1. Systematic Analysis of Accuracy in Predicting Complete Oncological Resection in Pancreatic Cancer Patients-Proposal of a New Simplified Borderline Resectability Definition. Bolm L, Mueller K, May K, Sondermann S, Petrova E, Lapshyn H, Honselmann KC, Bausch D, Zemskov S, Bronsert P, Keck T, Deichmann S, Wellner UF. Cancers (Basel). 2020 Apr 4;12(4):E882. doi: 10.3390/cancers12040882

2. Distinct bone marrow morphologic features discriminate myelodysplastic syndromes patients with and without an early platelet response to decitabine. May AM, Stomper J, Joeckel TE, Bronsert P, Wijermans PW, Werner M, Lübbert M. Br J Haematol. 2020 Mar 24. doi: 10.1111/bjh.16615. Online ahead of print.

3. γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivity
Janssen A, et al. Cancer Immunol Res 2020. Among authors: Bronsert P. PMID 32019779

4. A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer
Romero JM, et al. Clin Cancer Res 2020. Among authors: Bronsert P. PMID 31964786

5. Conditional Gene Targeting Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.
Parigiani MA, Ketscher A, Timme S, Bronsert P, Schlimpert M, Kammerer B, Jacquel A, Chaintreuil P, Reinheckel T. Cancers (Basel). 2020 Jul 22;12(8):E2004. doi: 10.3390/cancers12082004. PMID: 32707827

6. FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro. Mohamed AA, Thomsen A, Follo M, Zamboglou C, Bronsert P, Mostafa H, Amen A, Mekawy M, Grosu AL, Brunner TB. Strahlenther Onkol. 2020 Jul 23. doi: 10.1007/s00066-020-01666-0. Online ahead of print. PMID: 32705304

7. Alignment of stroma fibers, microvessel density and immune cell populations determine overall survival in pancreatic cancer-An analysis of stromal morphology. Bolm L, Zghurskyi P, Lapshyn H, Petrova E, Zemskov S, Vashist YK, Deichmann S, Honselmann KC, Bronsert P, Keck T, Wellner UF. PLoS One. 2020 Jul 13;15(7):e0234568. doi: 10.1371/journal.pone.0234568. eCollection 2020. PMID: 32658932 Free PMC article.

8. Deep multiple instance learning classifies subtissue locations in mass spectrometry images from tissue-level annotations.
Guo D, Föll MC, Volkmann V, Enderle-Ammour K, Bronsert P, Schilling O, Vitek O. Bioinformatics. 2020 Jul 1;36(Supplement_1):i300-i308. doi: 10.1093/bioinformatics/btaa436. PMID: 32657378 Free PMC article.

9. Evaluation of molecular subtypes and clonal selection during establishment of patient-derived tumor xenografts from gastric adenocarcinoma. Peille AL, Vuaroqueaux V, Wong SS, Ting J, Klingner K, Zeitouni B, Landesfeind M, Kim WH, Lee HJ, Kong SH, Wulur I, Bray S, Bronsert P, Zanella N, Donoho G, Yang HK, Fiebig HH, Reinhard C, Aggarwal A. Commun Biol. 2020 Jul 9;3(1):367. doi: 10.1038/s42003-020-1077-z. PMID: 32647357 Free PMC article.

10. Association between gastrin-releasing peptide receptor expression as assessed with [68Ga]Ga-RM2 PET/CT and histopathological tumor regression after neoadjuvant chemotherapy in primary breast cancer.
Michalski K, Stoykow C, Bronsert P, Juhasz-Böss I, Meyer PT, Ruf J, Erbes T, Asberger J. Nucl Med Biol. 2020 Jul-Aug;86-87:37-43. doi: 10.1016/j.nucmedbio.2020.05.003. Epub 2020 May 12. PMID: 32473549

11. Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: A development and validation study.
Reijnen C, Gogou E, Visser NCM, Engerud H, Ramjith J, van der Putten LJM, van de Vijver K, Santacana M, Bronsert P, Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Reques A, Mancebo G, Krakstad C, Trovik J, Haldorsen IS, Huvila J, Koskas M, Weinberger V, Bednarikova M, Hausnerova J, van der Wurff AAM, Matias-Guiu X, Amant F; ENITEC Consortium, Massuger LFAG, Snijders MPLM, Küsters-Vandevelde HVN, Lucas PJF, Pijnenborg JMA. PLoS Med. 2020 May 15;17(5):e1003111. doi: 10.1371/journal.pmed.1003111. eCollection 2020 May. PMID: 32413043 Free PMC article. Clinical Trial.

12. Systematic Analysis of Accuracy in Predicting Complete Oncological Resection in Pancreatic Cancer Patients-Proposal of a New Simplified Borderline Resectability Definition.
Bolm L, Mueller K, May K, Sondermann S, Petrova E, Lapshyn H, Honselmann KC, Bausch D, Zemskov S, Bronsert P, Keck T, Deichmann S, Wellner UF. Cancers (Basel). 2020 Apr 4;12(4):882. doi: 10.3390/cancers12040882. PMID: 32260453 Free PMC article.

13. High Numbers and Densities of PD1+ T-Follicular Helper Cells in Triple-Negative Breast Cancer Draining Lymph Nodes Are Associated with Lower Survival. Bronsert P, von Schoenfeld A, Villacorta Hidalgo J, Kraft S, Pfeiffer J, Erbes T, Werner M, Seidl M. Int J Mol Sci. 2020 Aug 19;21(17):E5948. doi: 10.3390/ijms21175948. PMID: 32824917.

14. Pattern of Recurrence and Patient Survival after Perioperative Chemotherapy with 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) for Locally Advanced Esophagogastric Adenocarcinoma in Patients Treated Outside Clinical Trials. Glatz T, Verst R, Kuvendjiska J, Bronsert P, Becker H, Hoeppner J, Kulemann B. J Clin Med. 2020 Aug 16;9(8):E2654. doi: 10.3390/jcm9082654. PMID: 32824326.

15. Immunohistological composition of peri-implantitis affected tissue around ceramic implants - A pilot study. Fretwurst T, Müller J, Larsson L, Bronsert P, Hazard D, Castilho RM, Kohal R, Nelson K, Iglhaut G. J Periodontol. 2020 Aug 24. doi: 10.1002/JPER.20-0169. Online ahead of print. PMID: 32839977.

16. Intraprostatic Tumour Segmentation on PSMA-PET Images in Patients with Primary Prostate Cancer with a Convolutional Neural Network. Kostyszyn D, Fechter T, Bartl N, Grosu AL, Gratzke C, Sigle A, Mix M, Ruf J, Fassbender TF, Kiefer S, Bettermann AS, Nicolay NH, Spohn S, Kramer MU, Bronsert P, Guo H, Qiu X, Wang F, Henkenberens C, Werner RA, Baltas D, Meyer PT, Derlin T, Chen M, Zamboglou C. J Nucl Med. 2020 Oct 30:jnumed.120.254623. doi: 10.2967/jnumed.120.254623. Online ahead of print. PMID: 33127624

17. Cytopathological Heterogeneity of Circulating Tumor Cells in Non-metastatic Esophageal Adenocarcinoma. Kuvendjiska J, Pitman MB, Martini V, Braun C, Grebe K, Timme S, Fichtner-Feigl S, Glatz T, Schmoor C, Guenzle J, Hoeppner J, Kulemann B. Anticancer Res. 2020 Oct;40(10):5679-5685. doi: 10.21873/anticanres.14582.

18. Prognostic impact of tumor budding and EMT in periampullary adenocarcinoma: a quantitative approach. Kocsmár É, Lotz G, Kiss A, Hoerner M, Petrova E, Freudenberg N, Csanádi Á, Kulemann B, Werner M, Bronsert P, Wellner UF. J Cancer. 2020 Sep 17;11(22):6474-6483. doi: 10.7150/jca.46093. eCollection 2020. PMID: 33046968

19. Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer. Honselmann KC, Finetti P, Birnbaum DJ, Monsalve CS, Wellner UF, Begg SKS, Nakagawa A, Hank T, Li A, Goldsworthy MA, Sharma H, Bertucci F, Birnbaum D, Tai E, Ligorio M, Ting DT, Schilling O, Biniossek ML, Bronsert P, Ferrone CR, Keck T, Mino-Kenudson M, Lillemoe KD, Warshaw AL, Fernández-Del Castillo C, Liss AS. Mol Cancer Res. 2020 Sep 1. doi: 10.1158/1541-7786.MCR-20-0439. Online ahead of print. PMID: 32873625

20. Raman Spectroscopy to Characterize Bladder Tissue for Multidimensional Diagnostics of Cancer in Urology. C. Krafft , S. Guo, T. Bocklitz, J. Popp, P. Bronsert, A. Miernik. Current Directions in Biomedical Engineering, 26.11.2020

21. Uncovering the invisible-prevalence, characteristics, and radiomics feature-based detection of visually undetectable intraprostatic tumor lesions in 68GaPSMA-11 PET images of patients with primary prostate cancer. Zamboglou C, Bettermann AS, Gratzke C, Mix M, Ruf J, Kiefer S, Jilg CA, Benndorf M, Spohn S, Fassbender TF, Bronsert P, Chen M, Guo H, Wang F, Qiu X, Grosu AL. Eur J Nucl Med Mol Imaging. 2020 Nov 18. doi: 10.1007/s00259-020-05111-3.

22. Comparison of Manual and Semi-Automatic [18F]PSMA-1007  PET Based Contouring Techniques for Intraprostatic Tumor Delineation in  Patients With Primary Prostate Cancer and Validation With  Histopathology as Standard of Reference. Spohn SKB, Kramer M, Kiefer S, Bronsert P, Sigle A, Schultze-Seemann W, Jilg CA, Sprave T, Ceci L, Fassbender TF, Nicolay NH, Ruf J, Grosu AL, Zamboglou C. Front Oncol. 2020 Dec 7;10:600690. doi: 10.3389/fonc.2020.600690. eCollection 2020.PMID: 33365271  

23. The cut-off for estrogen and progesterone receptor in  endometrial cancer revisited: an ENITEC collaboration study. 
Jan van Weelden W, Reijnen C, Küsters-Vandevelde HVN, Bulten J, Bult P, Leung S, Visser NCM, Santacana M, Bronsert P,  Hirschfeld M, Colas E, Gil-Moreno A, Reques A, Mancebo G, Huvila J,  Koskas M, Weinberger V, Bednarikova M, Hausnerova J, Snijders MPLM,  Matias-Guiu X, Amant F; ENITEC-consortium, Krakstad C, van de Vijver K,  McAlpine J, Pijnenborg J. Hum Pathol. 2020 Dec 15:S0046-8177(20)30255-0. doi: 10.1016/j.humpath.2020.12.003. Online ahead of print. PMID: 33338506   

2019

1. A Lab-On-A-Chip for Rapid miRNA Extraction. Behrmann O, Hügle M, Bronsert P, Herde B, Heni J, Schramm M, Hufert FT, Urban GA, Dame G. PLoS One14 (12), e0226571 2019 Dec 19 eCollection 2019 DOI: 10.1371/journal.pone.0226571

2. Accessible and Reproducible Mass Spectrometry Imaging Data Analysis in Galaxy. Föll M, Moritz L, Wollmann T, Stilger M, Vockert N, Werner M, Bronsert P, Rohr K, Grüning B, Schilling O. Gigasience, 8 (12) 2019 Dec 1 DOI: 10.1371/journal.pone.0226571

3. Tumor Budding as a Prognostic Factor in Pancreatic Ductal Adenocarcinoma. Petrova E, Zielinski V, Bolm L, Schreiber C, Knief J, Thorns Ch,  Bronsert P, Timme-Bronsert S, Bausch D, Perner S, Keck T, Wellner U. Virchows Arch 2019 Nov 30[Online ahead of print] DOI: 10.1371/journal.pone.0226571

4. Validation of Different PSMA-PET/CT-based Contouring Techniques for Intraprostatic Tumor Definition Using Histopathology as Standard of Reference. Zamboglou C, Fassbender TF, Steffan L, Schiller F, Fechter T, Carles M, Kiefer S, Rischke H C, Reichel K, Schmidt-Hegemann NS, Ilhan H, Chirindel AF, Nicolas G, Henkenberens C, Derlin T, Bronsert P, Mavroidis P, Chen RC, Meyer PT, Ruf J, Grosu AL. Radiother Oncol. 141, 208-213 Dec 2019 DOI: 10.1371/journal.pone.0226571

5. [ ⁶⁸ Ga-]PSMA-11 PET/CT and Multiparametric MRI for Gross Tumor Volume Delineation in a Slice by Slice Analysis With Whole Mount Histopathology as a Reference Standard - Implications for Focal Radiotherapy Planning in Primary Prostate Cancer. Bettermann AS, Zamboglou C, Kiefer S, Jilg CA, Spohn S, Kranz-Rudolph J, Fassbender TF, Bronsert P, Nicolay NH, Gratzke C, Bock M, Ruf J, Benndorf M, Grosu AL. Radiother Oncol.141, 214-219 Dec 2019 DOI: 10.1371/journal.pone.0226571

6. Radiomic Features From PSMA PET for Non-Invasive Intraprostatic Tumor Discrimination and Characterization in Patients With Intermediate- And High-Risk Prostate Cancer - A Comparison Study With Histology Reference. Zamboglou C, Carles M, Fechter T, Kiefer S, Reichel K, Fassbender TF, Bronsert P, Koeber G, Schilling O, Ruf J, Werner M, Jilg CA, Baltas D, Mix M, Grosu AL. Theranostics, 9 (9), 2595-2605 2019 Apr 13 eCollection 2019 DOI: 10.1371/journal.pone.0226571

7. Addition of IMP3 to L1CAM for Discrimination Between Low- And High-Grade Endometrial Carcinomas: A European Network for Individualised Treatment of Endometrial Cancer Collaboration Study. Visser NCM, van der Putten LJM, van Egerschot A, van de Vijver KK, Santacana M, Bronsert P, Hirschfeld M, Colas E, Gil-Moreno A, Garcia A, Mancebo G, Alameda F, Krakstad C, Tangen IL, Huvila J, Schrauwen S, Koskas M, Walker F, Weinberger V, Minar L, Hausnerova J, Snijders MPLM, van den Berg-van Erp S, Matias-Guiu X, Trovik J, Amant F, Massuger LFAG, Bulten J, Pijnenborg JMA. Hum Pathol, 89, 90-98 Jul 2019 DOI: 10.1371/journal.pone.0226571

8. Poor Outcome in Hypoxic Endometrial Carcinoma Is Related to Vascular Density. Reijnen C, van Weelden WJ, Arts MSJP, Peters JP, Rijken PF, van de Vijver K, Santacana M, Bronsert P,  Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Reques A, Mancebo G, Krakstad C, Trovik J, Haldorsen IS, Huvila J, Koskas M, Weinberger V, Minar L, Jandakova E, Snijders MPLM, van den Berg-van Erp S, Küsters-Vandevelde HVN, Matias-Guiu X, Amant F, ENITEC-consortium, Massuger LFAG, Bussink J, Pijnenborg JMA. Br J Cancer 120 (11), 1037-1044 May 2019 DOI: 10.1371/journal.pone.0226571

9. Prognostic Relevance of Preoperative Bilirubin-Adjusted Serum Carbohydrate Antigen 19-9 in a Multicenter Subset Analysis of 179 Patients With Distal Cholangiocarcinoma. Bolm L, Petrova E, Weitz J, Rückert F, Wittel UA, Makowiec F, Lapshyn H, Bronsert P, Rau BM, Khatkov IE, Bausch D, Keck T, Wellner UF, Distler M
HPB (Oxford), 21 (11), 1513-1519 Nov 2019 DOI: 10.1371/journal.pone.0226571

10. Non-Metastatic Esophageal Adenocarcinoma: Circulating Tumor Cells in the Course of Multimodal Tumor Treatment. Kuvendjiska J, Bronsert P, Martini V, Lang S, Pitman MB, Hoeppner J, Kulemann B. Cancer (Basel), 11 (3) 2019 Mar 21 DOI: 10.1371/journal.pone.0226571

11. Genotyping of Circulating Cell-Free DNA Enables Noninvasive Tumor Detection in Myxoid Liposarcomas. Braig D, Becherer C, Bickert C, Braig M, Claus R, Eisenhardt AE, Heinz J, Scholber J, Herget GW, Bronsert P, Fricke A, Follo M, Stark GB, Bannasch H, Eisenhardt SU. Int J Cancer, 145 (4), 1148-1161 2019 Aug 15 DOI: 10.1371/journal.pone.0226571

12. ADAM9 Contributes to Vascular Invasion in Pancreatic Ductal Adenocarcinoma. Oria VO, Lopatta P, Schmitz T, Preca BT, Nytröm A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, Bronsert P, Schilling O. Mol Oncol, 13 (2), 456-479 Feb 2019 DOI: 10.1371/journal.pone.0226571

13. ATP in the Tumour Microenvironment Drives Expression of nfP2X ₇, a Key Mediator of Cancer Cell Survival. Gilbert SM, Oliphant CJ, Hassan S, Peille AL, Bronsert P, Falzoni S, Di Virgilio F, McNulty S, Lara R. Oncogene, 38 (2), 194-208 Jan 2019 DOI: 10.1371/journal.pone.0226571

2018

1. Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance. Oria VO, Bronsert P, Thomsen AR, Föll MC, Zamboglou C, Hannibal L, Behringer S, Biniossek ML, Schreiber C, Grosu AL, Bolm L, Rades D, Keck T, Werner M, Wellner UF, Schilling O. Transl Oncol. 2018 Aug 29;11(6):1307-1322. doi: 10.1016/j.tranon.2018.08.001.

2. ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival. Gilbert SM, Oliphant CJ, Hassan S, Peille AL, Bronsert P, Falzoni S, Di Virgilio F, McNulty S, Lara R. Oncogene. 2018 Aug 7. doi: 10.1038/s41388-018-0426-6.

3. Does the site of primary colorectal cancer influence the outcome after resection of isolated liver metastases? Makowiec F, Menzel M, Bronsert P, Holzner PA, Klock A, Lang SA, Fichtner-Feigl S, Neeff HP. Dig Liver Dis. 2018 Jun 30. pii: S1590-8658(18)30806-5. doi: 10.1016/j.dld.2018.06.019.

4. Intraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases. Le UT, Bronsert P, Picardo F, Riethdorf S, Haager B, Rylski B, Czerny M, Beyersdorf F, Wiesemann S, Pantel K, Passlick B, Kaifi JT, Schmid S. Sci Rep. 2018 Jun 8;8(1):8751. doi: 10.1038/s41598-018-26410-8.

5. Focal dose escalation for prostate cancer using 68Ga-HBED-CC PSMA PET/CT and MRI: a planning study based on histology reference. Zamboglou C, Thomann B, Koubar K, Bronsert P, Krauss T, Rischke HC, Sachpazidis I, Drendel V, Salman N, Reichel K, Jilg CA, Werner M, Meyer PT, Bock M, Baltas D, Grosu AL. Radiat Oncol. 2018 May 2;13(1):81. doi: 10.1186/s13014-018-1036-8.

6. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Küsters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M. Front Genet. 2018 Apr 5;9:108. doi: 10.3389/fgene.2018.00108. eCollection 2018.

7. Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization. Foell MC, Fahrner M, Oria VO, Kühs M, Biniossek ML, Werner M, Bronsert P, Schilling O. Clinical Proteomics, Accepted 2018

8. Intrahepatic cholangiocarcinoma : Results after 84 resections. Neeff HP, Holzner PA, Menzel M, Bronsert P, Klock A, Lang SA, Fichtner-Feigl S, Hopt UT, Makowiec F. Chirurg. 2018 Feb 20. doi: 10.1007/s00104-018-0609-2.

9. Added Value of Estrogen Receptor, Progesterone Receptor, and L1 Cell Adhesion Molecule Expression to Histology-Based Endometrial Carcinoma Recurrence Prediction Models: An ENITEC Collaboration Study. van der Putten LJM, Visser NCM, van de Vijver K, Santacana M, Bronsert P, Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Garcia A, Mancebo G, Alameda F, Trovik J, Kopperud RK, Huvila J, Schrauwen S, Koskas M, Walker F, Weinberger V, Minar L, Jandakova E, Snijders MPLM, van den Berg-van Erp S, Matias-Guiu X, Salvesen HB, Werner HMJ, Amant F, Massuger LFAG, Pijnenborg JMA. Int J Gynecol Cancer. 2018 Jan 10. doi: 10.1097/IGC.0000000000001187.

10. Viability and biocompatibility of an adhesive system for intrarenal embedding and endoscopic removal of small residual fragments in minimally-invasive stone treatment in an in vivo pig model. Hein S, Schoeb DS, Grunwald I, Richter K, Haberstroh J, Seidl M, Bronsert P, Wetterauer U, Schoenthaler M, Miernik A. World J Urol. 2018 Jan 24. doi: 10.1007/s00345-018-2188-8.

11. Prognostic influence of hepatic margin after resection of colorectal liver metastasis: role of modern preoperative chemotherapy. Makowiec F, Bronsert P, Klock A, Hopt UT, Neeff HP. Int J Colorectal Dis. 2018 Jan;33(1):71-78. doi: 10.1007/s00384-017-2916-3.

2017

12. A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement. Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rücker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG. Lab Chip. 2017 Dec 19;18(1):179-189. doi: 10.1039/c7lc00832e.

13. A molecular intravascular ultrasound contrast agent allows detection of activated platelets on the surface of symptomatic human plaques. Maier A, Plaza-Heck P, Meixner F, Guenther F, Kaufmann BA, Kramer M, Heidt T, Zirlik A, Hilgendorf I, Reinöhl J, Stachon P, Bronsert P, Birkemeyer R, Neudorfer I, Peter K, Bode C, von Zur Mühlen C. Atherosclerosis. 2017 Dec;267:68-77. doi: 10.1016/j.atherosclerosis.2017.10.029. Epub 2017 Oct 24.

14. KDM4 Inhibition Targets Breast Cancer Stem-like Cells. Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford JA, Kanouni T, Maurer J, Schüle R. Cancer Res. 2017 Nov 1;77(21):5900-5912. doi: 10.1158/0008-5472.CAN-17-1754. Epub 2017 Sep 7.

15. Anti-Phosphohistone H3-Positive Mitoses Are Linked to Pathological Response in Neoadjuvantly Treated Breast Cancer. Sillem M, Timme S, Bronsert P, Bogatyreva L, Hauschke D, Zur Hausen A, Werner M, Stickeler E. Breast Care (Basel). 2017 Sep;12(4):244-250. doi: 10.1159/000463377. Epub 2017 Aug 2. Erratum in: Breast Care (Basel). 2017 Oct;12 (5):343.

16. Survival outcome and prognostic factors after pancreatoduodenectomy for distal bile duct carcinoma: a retrospective multicenter study. Petrova E, Rückert F, Zach S, Shen Y, Weitz J, Grützmann R, Wittel UA, Makowiec F, Hopt UT, Bronsert P, Kühn F, Rau BM, Izrailov RE, Khatkov IE, Lapshyn H, Bolm L, Bausch D, Keck T, Wellner UF, Seifert G. Langenbecks Arch Surg. 2017 Aug;402(5):831-840. doi: 10.1007/s00423-017-1590-9. Epub 2017 Jun 13.

17. Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, Martini V, Kuvendjiska J, Glatz T, Hussung S, Fritsch R, Becker H, Pitman MB, Hoeppner J. Sci Rep. 2017 Jul 3;7(1):4510. doi: 10.1038/s41598-017-04601-z.

18. The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Krebs AM, Mitschke J, Losada ML, Schmalhofer O, Boerries M, Busch H, Boettcher M, Mougiakakos D, Reichardt W, Bronsert P, Brunton VG, Pilarsky C, Winkler TH, Brabletz S, Stemmler MP, Brabletz T. Nat Cell Biol. 2017 Apr 17. doi: 10.1038/ncb3513.

19. Sensitivity of Helicobacter pylori detection by Giemsa staining is poor in comparison with immunohistochemistry and fluorescent in situ hybridization and strongly depends on inflammatory activity. Kocsmár É, Szirtes I, Kramer Z, Szijártó A, Bene L, Buzás GM, Kenessey I, Bronsert P, Csanadi A, Lutz L, Werner M, Wellner UF, Kiss A, Schaff Z, Lotz G. Helicobacter. 2017 Apr 12. doi: 10.1111/hel.12387.

20. A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer. Preca BT, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, Matzge-Ogi A, Orian-Rousseau V, Brabletz S, Brabletz T, Maurer J, Stemmler MP. Oncotarget. 2017 Feb 14;8(7):11530-11543. doi: 10.18632/oncotarget.14563.

2016

21. Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O. J Cancer. 2016 Oct 17;7(14):2018-2027. eCollection 2016.

22. TNM-O: ontology support for staging of malignant tumours. Boeker M, França F, Bronsert P, Schulz S. J Biomed Semantics. 2016 Nov 14;7(1):64.

23. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J. Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.

24. L1CAM expression in endometrial carcinomas: an ENITEC collaboration study. van der Putten LJ, Visser NC, van de Vijver K, Santacana M, Bronsert P, Bulten J, Hirschfeld M, Colas E, Gil-Moreno A, Garcia A, Mancebo G, Alameda F, Trovik J, Kopperud RK, Huvila J, Schrauwen S, Koskas M, Walker F, Weinberger V, Minar L, Jandakova E, Snijders MP, van den Berg-van Erp S, Matias-Guiu X, Salvesen HB, Amant F, Massuger LF, Pijnenborg JM. Br J Cancer. 2016 Sep 6;115(6):716-24. doi: 10.1038/bjc.2016.235. Epub 2016 Aug 9.

25. ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Röthling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR. BMC Cancer. 2016 Jul 19;16:503. doi: 10.1186/s12885-016-2564-y.

26. Gastrin-releasing Peptide Receptor Imaging in Breast Cancer Using the Receptor Antagonist 68Ga-RM2 And PET Stoykow C, Erbes T, Maecke HR, Bulla S, Bartholomä M, Mayer S, Drendel V, Bronsert P, Werner M, Gitsch G, Weber WA, Stickeler E, Meyer PT. Theranostics 2016; 6(10):1641-1650. doi:10.7150/thno.14958.

27. Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini. Lai ZW, Weisser J, Nilse L, Costa F, Keller E, Tholen M, Kizhakkedathu JN, Biniossek M, Bronsert P, Schilling O. Mol Cell Proteomics. 2016 Jun;15(6):2203-13. doi: 10.1074/mcp.O115.056515. Epub 2016 Apr 17.

28. Structured reporting ensures complete content and quick detection of essential data in pathology reports of oncological breast resection specimens. Aumann K, Niermann K, Asberger J, Wellner U, Bronsert P, Erbes T, Hauschke D, Stickeler E, Gitsch G, Kayser G, Werner M. Breast Cancer Res Treat. 2016 Apr;156(3):495-500. doi: 10.1007/s10549-016-3769-0. Epub 2016 Apr 8.

2015

29. KRAS mutations in pancreatic circulating tumor cells: a pilot study. Kulemann B, Liss AS, Warshaw AL, Seifert S, Bronsert P, Glatz T, Pitman MB, Hoeppner J. Tumour Biol. 2015 Dec 18.

30. Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform. Schaal K, Hirschfeld M, Bronsert P, Füllgraf H, Jäger M, Herde B, Nöthling C, Mayer S, Erbes T, Stickeler E. Oncotarget. 2015 Sep 8;6(26):22553-63.

31. Identification of a blood-borne miRNA signature of synovial sarcoma. Fricke A, Ullrich PV, Heinz J, Pfeifer D, Scholber J, Herget GW, Hauschild O, Bronsert P, Stark GB, Bannasch H, Eisenhardt SU, Braig D. Mol Cancer. 2015 Aug 7;14:151. doi: 10.1186/s12943-015-0424-z.

32. Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines. Weißer J, Lai ZW, Bronsert P, Kuehs M, Drendel V, Timme S, Kuesters S, Jilg CA, Wellner UF, Lassmann S, Werner M, Biniossek ML, Schilling O. BMC Genomics. 2015 Jul 29;16:559. doi: 10.1186/s12864-015-1768-x.

33. Perioperative platin-based chemotherapy for locally advanced esophagogastric adenocarcinoma: Postoperative chemotherapy has a substantial impact on outcome. Glatz T, Bronsert P, Schäfer M, Kulemann B, Marjanovic G, Sick O, Hopt UT, Zirlik K, Makowiec F, Hoeppner J. Eur J Surg Oncol. 2015 Jul 29. pii: S0748-7983(15)00553-3. doi: 10.1016/j.ejso.2015.07.010.

34. Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767): Perioperative and Long-term Results of a Multicenter Randomized Controlled Trial. Keck T, Wellner UF, Bahra M, Klein F, Sick O, Niedergethmann M, Wilhelm TJ, Farkas SA, Börner T, Bruns C, Kleespies A, Kleeff J, Mihaljevic AL, Uhl W, Chromik A, Fendrich V, Heeger K, Padberg W, Hecker A, Neumann UP, Junge K, Kalff JC, Glowka TR, Werner J, Knebel P, Piso P, Mayr M, Izbicki J, Vashist Y, Bronsert P, Bruckner T, Limprecht R, Diener MK, Rossion I, Wegener I, Hopt UT. Ann Surg. 2015 Jul 1.

35. Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T. J Biol Chem. 2015 Jun 19;290(25):15758-69. doi: 10.1074/jbc.M114.624353. Epub 2015 May

36. Assessing quality and functionality of DNA isolated from FFPE tissues through external quality assessment in tissue banks. Ahmad-Nejad P, Duda A, Sucker A, Werner M, Bronsert P, Stickeler E, Reifenberger G, Malzkorn B, Oberländer M, Habermann JK, Bruch HP, Linnebacher M, Schadendorf D, Neumaier M. Clin Chem Lab Med. 2015 Jun 6. pii: /j/cclm.ahead-of-print/cclm-2014-1202/cclm-2014-1202.xml. doi: 10.1515/cclm-2014-1202

37. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. Meidhof S, Brabletz S, Lehmann W, Preca BT, Mock K, Ruh M, Schüler J, Berthold M, Weber A, Burk U, Lübbert M, Puhr M, Culig Z, Wellner U, Keck T, Bronsert P, Küsters S, Hopt UT, Stemmler MP, Brabletz T. EMBO Mol Med. 2015 Apr 14;7(6):831-47. doi: 10.15252/emmm.201404396.

38. Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer. Pérez-Gómez E, Andradas C, Blasco-Benito S, Caffarel MM, García-Taboada E, Villa-Morales M, Moreno E, Hamann S, Martín-Villar E, Flores JM, Wenners A, Alkatout I, Klapper W, Röcken C, Bronsert P, Stickeler E, Staebler A, Bauer M, Arnold N, Soriano J, Pérez-Martínez M, Megías D, Moreno-Bueno G, Ortega-Gutiérrez S, Artola M, Vázquez-Villa H, Quintanilla M, Fernández-Piqueras J, Canela EI, McCormick PJ, Guzmán M, Sánchez C. J Natl Cancer Inst. 2015 Apr 8;107(6):djv077. doi: 10.1093/jnci/djv077. Print 2015 Jun.

39. Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma. Kohler I, Bronsert P, Timme S, Werner M, Brabletz T, Hopt UT, Schilling O, Bausch D, Keck T, Wellner UF. J Gastroenterol Hepatol. 2015 Mar;30 Suppl 1:78-84. doi: 10.1111/jgh.12752.

40. Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceral resection for pancreatic head cancer. Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceral resection for pancreatic head cancer.Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, Bronsert P, Sick O, Hopt UT, Makowiec F, Riediger H. J Gastrointest Surg. 2015 Mar;19(3):438-44. doi: 10.1007/s11605-014-2725-8. Epub 2015 Jan 8.

41. Radiotherapy for SMAD4-negative musculoskeletal lesions from pancreatic cancer: case report and review. Zamboglou C, Bronsert P, Küsters S, Salm N, Azèmar M, Brunner T. Strahlenther Onkol. 2015 Jan;191(1):67-72. doi: 10.1007/s00066-014-0764-4. Epub 2014 Oct 10

2014

42. Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas. Hidalgo JV, Bronsert P, Orlowska-Volk M, Díaz LB, Stickeler E, Werner M, Schmitt-Graeff A, Kayser G, Malkovsky M, Fisch P. Front Immunol. 2014 Dec 10;5:632. doi: 10.3389/fimmu.2014.00632. eCollection 2014. Hybrid laparoscopic versus open pylorus-preserving pancreatoduodenectomy: retrospective matched case comparison in 80 patients.

43. Wellner UF, Küsters S, Sick O, Busch C, Bausch D, Bronsert P, Hopt UT, Karcz KW, Keck T. Langenbecks Arch Surg. 2014 Oct;399(7):849-56. doi: 10.1007/s00423-014-1236-0. Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging.

44. von Elverfeldt D, Maier A, Duerschmied D, Braig M, Witsch T, Wang X, Mauler M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Bronsert P, Bode C, Peter K, von Zur Muhlen C. Circulation. 2014 Aug 19;130(8):676-87. doi: 10.1161/CIRCULATIONAHA.113.008157.

45. Double 90 Degrees Counterrotated End-to-End-Anastomosis: An Experimental Study of an Intestinal Anastomosis Technique. Holzner P, Kulemann B, Seifert G, Glatz T, Chikhladze S, Höppner J, Hopt U, Timme S, Bronsert P, Sick O, Zhou C, Marjanovic G. Eur J Pediatr Surg. 2014 May 12.

46. Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients. Hoeppner J, Zirlik K, Brunner T, Bronsert P, Kulemann B, Sick O, Marjanovic G, Hopt UT, Makowiec F. J Surg Oncol. 2014 Mar;109(3):287-93. doi: 10.1002/jso.23498.

2013

47. Intraoperative crystalloid overload leads to substantial inflammatory infiltration of intestinal anastomoses-a histomorphological analysis. Kulemann B, Timme S, Seifert G, Holzner PA, Glatz T, Sick O, Chikhladze S, Bronsert P, Hoeppner J, Werner M, Hopt UT, Marjanovic G. Surgery. 2013 Sep;154(3):596-603. doi: 10.1016/j.surg.2013.04.010.

48. The format type has impact on the quality of pathology reports of oncological lung resection specimens. Aumann K, Kayser G, Amann D, Bronsert P, Hauschke D, Palade E, Passlick B, Werner M. Lung Cancer. 2013 Sep;81(3):382-7. doi: 10.1016/j.lungcan.2013.05.017.

49. Improved long-term survival after esophagectomy for esophageal cancer: influence of epidemiologic shift and neoadjuvant therapy. Makowiec F, Baier P, Kulemann B, Marjanovic G, Bronsert P, Zirlik K, Henke M, Hopt UT, Hoeppner J. J Gastrointest Surg. 2013 Jul;17(7):1193-201. doi: 10.1007/s11605-013-2212-7.

50. Limited resection for duodenal gastrointestinal stromal tumors: Surgical management and clinical outcome. Hoeppner J, Kulemann B, Marjanovic G, Bronsert P, Hopt UT. World J Gastrointest Surg. 2013 Feb 27;5(2):16-21.

51. Outcome after repeat resection of liver metastases from colorectal cancer. Neeff HP, Drognitz O, Holzner P, Klock A, Bronsert P, Hopt UT, Makowiec F. Int J Colorectal Dis. 2013 Aug;28(8):1135-41. doi: 10.1007/s00384-013-1670-4.