Experimental Epilepsy ResearchDepartment of Neurosurgery

Carola A. Haas, Prof. Dr. rer. nat.

Leader of the Experimental Epilepsy Research group, Department of Neurosurgery, Medical Faculty, University of Freiburg

 

 

 

 

 

 

• Curriculum vitae

 

Education/Training

Employment/Experience

Honors, Awards, and Scholarships

Other Scientific Activities

• Publications (PubMed)

Schwaderlapp N, Paschen E, LeVan P, Von Elverfeldt D, Haas CA (2024) Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI. Frontiers in Neuroimaging. doi: 10.3389/fnimg.2024.1423770 (access to article)

Donkels D, Huber S, Demerath T, Scheiwe C, Shah MJ, Heers M, Urbach H, Schulze-Bonhage A, Prinz M, Häussler U, Vlachos A, Beck J, Nakagawa JM, Haas CA (2024) Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobe. doi: 10.1101/2024.03.02.582894 (access preprint)

Kleis P, Paschen E, Häussler U, Haas CA (2024) Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit. Brain Stimulation. doi: 10.1016/j.brs.2024.03.017. (access to article)

Paschen E, Kleis P, Vieira DM, Heining K, Böhler C, Egert U, Häussler U, Haas CA (2024) On-demand low-frequency stimulation for seizure control: efficacy and behavioral implications Brain awad299. doi: 10.1093/brain/awad299 (access to article)

Häussler U, Neres J, Vandenplas C, Eykens C, Kadiu I, Schramm C, Fleurance R, Stanley P, Godard P, de Mot L, van Eyll J, Knobeloch KP, Haas CA, Dedeurwaerdere S (2023) Downregulation of ubiquitin-specific protease 15 (USP15) does not provide therapeutic benefit in experimental mesial temporal lobe epilepsy. Molecular Neurobiology. doi: 10.1007/s12035-023-03692-2 (access to article)

Frase S, Steddin J, Paschen E, Lenz M, Conforti P, Haas CA, Vlachos A, Schachtrup C, Hosp JA (2023) Dense dopaminergic innervation of the peri-infarct cortex despite of dopaminergic cell loss after a pure motor-cortical stroke in rats. J. of Neurochem. 167: 427-440. doi:10.1111/jnc.15970 (access to article)

Franz J, Barheier N, Tulke S, Haas CA, Häussler U (2022) Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy. bioRxiv 2022.06.02.494518. doi:https://doi.org/10.1101/2022.06.02.494518. (access to article)

Kleis P, Paschen E, Häussler U, Bernal Sierra YA, Haas CA (2022) Long-term in vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. BMC Biology 20:18. doi: 10.1186/s12915-021-01210-1 (access to article)

Haas CA (2021) Revisiting brain stimulation in Parkinson's. Invited Perspective, Science 374:153-154. (access to article)

Demerath T*, Donkels C*, Reisert M, Heers M, Rau A, Schröter N, Schulze-Bonhage A, Reinacher P, Scheiwe C, Shah MJ, Beck J, Vlachos A, Haas CA, Urbach H (2022) Gray-white matter blurring of the temporal pole associated with hippocampal sclerosis: A microstructural study involving 3T MRI and ultrastructural histopathology. Cerebral Cortex 32 (9):1882-1893. doi:10.1093/cercor/bhab320. *equal contribution (access to article)

Orcinha C, Kilias A, Paschen E, Follo M and Haas CA (2021) Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus. Front. Mol. Neurosci. 14:730811. doi: 10.3389/fnmol.2021.730811. (access to article)

Joseph K, Kirsch M, Johnston M, Münkel C, Stieglitz T, Haas CA, Hofmann UG (2021) Transcriptional trajectory of glial response during chronic neural implantation of flexible microprobes. BioRxiv doi.org/10.1101/2021.05.31.446394. (access to article)

Freiman TM, Häussler U, Zentner J, Dooskamp S, Beck J, Scheiwe C; Brandt A, Haas CA, Puhahn-Schmeiser B (2021) Hippocampal mossy fiber sprouting into CA2 in temporal lobe epilepsy. Hippocampus. doi: 10.1002/hipo.23323. (access to article)

Vieira DM, Kilias A, Diehl M, Haas CA, Egert U (2021) Adaptive Control of Sinusoidal Optogenetic Stimulation. 10th International IEEE/EMBS Conference on Neural Engineering (NER), 2021, pp. 275-280, doi: 10.1109/NER49283.2021.944118. (access to article)

Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife 9:e54518. doi: 10.7554/eLife.54518. (access to article)

Göbel-Guéniot K*, Gerlach J*, Kamberger R, Leupold J, von Elverfeldt D, Hennig J, Korvink JG, Haas CA*, LeVan P* (2020) Histological correlates of diffusion-weighted magnetic resonance microscopy in a mouse model of mesial temporal lobe epilepsy. Front. Neurosci. 14: 543. Brain Imaging Methods; Research Topic Advanced Imaging Methods in Neuroscience. *equal contribution. doi: 10.3389/fnins.2020.00543. (access to article)

Donkels C, Peters M, Fariña Núñez MT, Nakagawa JM, Kirsch M, Vlachos A, Scheiwe C, Schulze‐Bonhage A, Prinz M, Beck J, Haas CA (2020) Oligodendrocyte lineage and myelination are compromised in the gray matter of focal cortical dysplasia type IIa. Epilepsia 61:171-184. (access to article)

Heining K, Kilias A, Janz P, Häussler U, Kumar A, Haas CA, Egert U (2019) Bursts with high and low load of epileptiform spikes show context-dependent correlations in epileptic mice. eNeuro 6:0299-18. (access to article )

Tulke S, Haas CA, Häussler U (2019) Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity. Epilepsia 60:1234-1247.(access to article) 

Böhm T, Joseph K, Kirsch M, Moroni R, Hilger A, Osenberg M, Manke I, Johnston M, Stieglitz T, Hofmann UG, Haas CA, Thiele S. (2019) Quantitative synchrotron X‐ray tomography of the material‐tissue interface in rat cortex implanted with neural probes. Sci Rep 9: 7646. (access to article)

Szczurkowska J, Pischedda F, Pinto B, Manago F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L (2018). Negr1 and FGFR2 cooperatively regulate cortical development and core behaviors related to autism spectrum disorders in mice. Brain 141:2772-2794 (access to article)

Janz P*, Hauser P*, Heining K, Nestel S, Kirsch M, Egert U, Haas CA (2018) Position- and time-dependent Arc expression links neuronal activity to synaptic plasticity during epileptogenesis. Frontiers Cell Neurosci 12:244 (access to article)

Kamberger R, Göbel-Guéniot K, Gerlach J; Gruschke OG; Hennig J; LeVan P; Haas CA; Korvink JG (2018) Improved method for MR microscopy of brain tissue cultured with the interface method combined with Lenz lenses. Magnetic Resonance Imaging 52: 24-32. (access to article)

Kilias A, Häussler U, Heining K, Froriep UP, Haas CA, Egert U (2018) Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model. Hippocampus 28: 375-391. DOI: 10.1002/hipo.22838. (access to article)

Singh K, Loreth D, Pöttker B, Hefti K, Innos J, Schwald K, Hengstler H, Menzel L, Sommer CJ, Radyushkin K, Kretz O, Philips MA, Haas CA, Frauenknecht K, Lilleväli K, Heimrich B, Vasar E, Schaefer MKE (2018)Neuronal growth and behavioral alterations in mice deficient for the psychiatric disease-associated Negr1 gene. Front. Mol. Neurosci. 11:30, doi: 10.3389/fnmol.2018.00030. (access to article)

Gremmelspacher T, Gerlach J, Hubbe A, Haas CA, Häussler U (2017) Neurogenic processes induced by very short periods of voluntary wheel-running in male mice. Front. Neurosci. 11:385. doi: 10.3389/fnins.2017.00385 (access to article)

Janz P*, Schwaderlapp N*, Heining K*, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P*, Haas CA* (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. *equal contribution. eLife 2017;6:e25742 doi: 10.7554/eLife.25742 (access to article)

Nakagawa JM, Donkels C, Fauser S, Schulze-Bonhage A, Prinz M, Zentner J, Haas CA (2017). Characterization of focal cortical dysplasia with balloon cells by layer-specific markers: evidence for differential vulnerability of interneurons. Epilepsia 58(4):635-645. (access to article)

Janz P, Savanthrapadian S, Häussler U, Kilias A, Nestel S, Kretz O, Kirsch M, Bartos M, Egert U, Haas CA (2017) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. Cerebral Cortex 27 (3): 2348-2364. (access to article)

Donkels C, Pfeifer D, Janz P, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Weyerbrock A, Zentner J, Haas CA (2017) Whole transcriptome screening reveals myelination deficits in dysplastic human temporal neocortex. Cerebral Cortex 27 (2): 1558-1572. (access to article)

Orcinha C, Münzner G, Gerlach J, Kilias A, Follo M, Egert U, Haas CA (2016) Seizure-induced motility of differentiated dentate granule cells is prevented by the central Reelin fragment. Frontiers in Cellular Neuroscience 10: 183. (access to article)

Gerlach J, Donkels C, Muenzner G, Haas CA (2016) Persistent gliosis interferes with neurogenesis in organotypic hippocampal slice cultures.  Frontiers in Cellular Neuroscience 10: 131. (access to article)

Egger K, Janz P, Döbrössy M, Bienert T, Reisert M, Obmann M, Glauche V, Haas CA, Harsan L, Urbach H, von Elverfeldt D (2016) Microstructural effects of a neuro-modulating drug evaluated by Diffusion Tensor Imaging. Neuroimage 127: 1-10. (access to article)

Häussler U, Rinas K, Kilias A, Egert U, Haas CA (2016) Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. Hippocampus 26: 577-88. doi:10.1002/hipo.22543. (access to article)

Hornig T, Haas CA, Sturm L, Fiebich B, Tebartz van Elst L (2015) Increased blood-reelin-levels in first episode schizophrenia. PLoS One 10(8):e0134671. (access to article)

Winkelmann A, You X, Grünewald N, Haeussler U, Krestel H, Haas CA, Schwarz G, Chen W, Meier J (2015) Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS One 10:e0125413. (access to article)

Bedner P, Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, Deshpande T, Schramm J, Häussler U, Haas CA, Henneberger C, Theis M, Steinhäuser C (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138:1208–1222. (access to article)

Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Haussler U, Juttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC (2014) Changes in neural network homeostasis trigger neuropsychiatric symptoms. The Journal of Clinical Investigation 124:696-711. (access to article)

Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Haussler U, Young C, Haas CA, Frotscher M (2014) Epilepsy-Induced Motility of Differentiated Neurons. Cerebral Cortex 24:2130-2140. (access to article)

Fauser S, Haussler U, Donkels C, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Zentner J, Haas CA (2013) Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: evidence from layer-specific marker expression. Acta Neuropathologica Communications 1:47. (access to article)

Dugladze T, Maziashvili N, Borgers C, Gurgenidze S, Haussler U, Winkelmann A, Haas CA, Meier JC, Vida I, Kopell NJ, Gloveli T (2013) GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice. Proceedings of the National Academy of Sciences of the United States of America 110:15073-15078. (access to article)

Tinnes S, Ringwald J, Haas CA (2013) TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27:2542-2552. (access to article)

Kirchheim F, Tinnes S, Haas CA, Stegen M, Wolfart J (2013) Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy. Frontiers in Cellular Neuroscience 7:248. (access to article)

Marx M, Haas CA, Haussler U (2013) Differential vulnerability of interneurons in the epileptic hippocampus. Frontiers in Cellular Neuroscience 7:167. (access to article)

Kierdorf K, Katzmarski N, Haas CA, Prinz M (2013) Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias. PloS One 8:e58544. (access to article)

Sibbe M, Haussler U, Dieni S, Althof D, Haas CA, Frotscher M (2012) Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus. The European Journal of Neuroscience 36:3643-3652. (access to article)

Haussler U, Bielefeld L, Froriep UP, Wolfart J, Haas CA (2012) Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy. Cerebral Cortex 22:26-36. (access to article)

Froriep UP, Kumar A, Cosandier-Rimele D, Haussler U, Kilias A, Haas CA, Egert U (2012) Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy. Epilepsia 53:1937-1947. (access to article)

Bechstein M, Haussler U, Neef M, Hofmann HD, Kirsch M, Haas CA (2012) CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy. Experimental Neurology 236:141-150. (access to article)

Gross CM, Flubacher A, Tinnes S, Heyer A, Scheller M, Herpfer I, Berger M, Frotscher M, Lieb K, Haas CA (2012) Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated action. Hippocampus 22:409-420. (access to article)

Herpfer I, Hezel H, Reichardt W, Clark K, Geiger J, Gross CM, Heyer A, Neagu V, Bhatia H, Atas HC, Fiebich BL, Bischofberger J, Haas CA, Lieb K, Normann C (2012) Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice. PloS One 7:e46004. (access to article)

Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, de Angelis MH, Herzig S, Brummendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schafer MK (2012) Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PloS One 7:e41537. (access to article)

Heinrich C, Lahteinen S, Suzuki F, Anne-Marie L, Huber S, Haussler U, Haas C, Larmet Y, Castren E, Depaulis A (2011) Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of Disease 42:35-47. (access to article)

Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM (2011) Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy. Epilepsia 52:1579-1589. (access to article)

Tinnes S, Schafer MK, Flubacher A, Munzner G, Frotscher M, Haas CA (2011) Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25:1002-1013. (access to article)

Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, Haas CA, Kempermann G, Taylor V, Giachino C (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 6:445-456. (access to article)

Wagener RJ, David C, Zhao S, Haas CA, Staiger JF (2010) The somatosensory cortex of reeler mutant mice shows absent layering but intact formation and behavioral activation of columnar somatotopic maps. The Journal of Neuroscience 30:15700-15709. (access to article)

Haas CA, Frotscher M (2010) Reelin deficiency causes granule cell dispersion in epilepsy. Experimental Brain Research 200:141-149. (access to article)

Kowalski J, Geuting M, Paul S, Dieni S, Laurens J, Zhao S, Drakew A, Haas CA, Frotscher M, Vida I (2010) Proper layering is important for precisely timed activation of hippocampal mossy cells. Cerebral Cortex 20:2043-2054. (access to article)

Muller MC, Osswald M, Tinnes S, Haussler U, Jacobi A, Forster E, Frotscher M, Haas CA (2009) Exogenous reelin prevents granule cell dispersion in experimental epilepsy. Experimental Neurology 216:390-397. (access to article)

Young CC, Stegen M, Bernard R, Muller M, Bischofberger J, Veh RW, Haas CA, Wolfart J (2009) Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy. The Journal of Physiology 587:4213-4233. (access to article)

Frotscher M, Chai X, Bock HH, Haas CA, Forster E, Zhao S (2009) Role of Reelin in the development and maintenance of cortical lamination. Journal of Neural Transmission 116:1451-1455. (access to article)

Mantovani M, Moser A, Haas CA, Zentner J, Feuerstein TJ (2009) GABA(A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain? Naunyn-Schmiedeberg's Archives of Pharmacology 380:45-58. (access to article)

Stegen M, Young CC, Haas CA, Zentner J, Wolfart J (2009) Increased leak conductance in dentate gyrus granule cells of temporal lobe epilepsy patients with Ammon's horn sclerosis. Epilepsia 50:646-653. (access to article)

Najm J, Horn D, Wimplinger I, Golden JA, Chizhikov VV, Sudi J, Christian SL, Ullmann R, Kuechler A, Haas CA, Flubacher A, Charnas LR, Uyanik G, Frank U, Klopocki E, Dobyns WB, Kutsche K (2008) Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nature Genetics 40:1065-1067. (access to article)

Deller T, Bas Orth C, Del Turco D, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 189:5-16. (access to article)

Fahrner A, Kann G, Flubacher A, Heinrich C, Freiman TM, Zentner J, Frotscher M, Haas CA (2007) Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. Experimental Neurology 203:320-332. (access to article)

Deller T, Haas CA, Freiman TM, Phinney A, Jucker M, Frotscher M (2006) Lesion-induced axonal sprouting in the central nervous system. Advances in Experimental Medicine and Biology 557:101-121. (access to article)

Heinrich C, Nitta N, Flubacher A, Muller M, Fahrner A, Kirsch M, Freiman T, Suzuki F, Depaulis A, Frotscher M, Haas CA (2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. The Journal of Neuroscience 26:4701-4713. (access to article)

Schwarzacher SW, Vuksic M, Haas CA, Burbach GJ, Sloviter RS, Deller T (2006) Neuronal hyperactivity induces astrocytic expression of neurocan in the adult rat hippocampus. Glia 53:704-714. (access to article)

Czarnecki K, Haas CA, Bas Orth C, Deller T, Frotscher M (2005) Postnatal development of synaptopodin expression in the rodent hippocampus. The Journal of Comparative Neurology 490:133-144. (access to article)

Bas Orth C, Vlachos A, Del Turco D, Burbach GJ, Haas CA, Mundel P, Feng G, Frotscher M, Deller T (2005) Lamina-specific distribution of Synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. The Journal of Comparative Neurology 487:227-239. (access to article)

 

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