Piret Kleis, M. Sc.
PhD student
- Research interests and techniques
Intrahippocampal kainate mouse model for mesial temporal lobe epilepsy (MTLE)
Optogenetic and electric low-frequency stimulation (LFS) for seizure interference in MTLE
Identifying optimal cellular targets and stimulation parameters for seizure suppression in the entorhinal-hippocampal circuit
Long-term effects of hippocampal LFS on seizure activity, plasticity, and behavior (anxiety, learning and memory)
Methods: in vivo electrophysiology, immunohistochemistry, in situ hybridization, microscopy, behavioral tests
- Publications
Kleis P, Paschen E, Häussler U, Haas CA (2024) Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit. Brain Stimulation. doi: 10.1016/j.brs.2024.03.017. (access to article)
Paschen E, Kleis P, Vieira DM, Heining K, Böhler C, Egert U, Häussler U, Haas CA (2024) On-demand low-frequency stimulation for seizure control: efficacy and behavioral implications Brain. doi: 10.1093/brain/awad299 (access to article)
Kleis P, Paschen E, Häussler U, Bernal Sierra YA, Haas CA (2022) Long-term in vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus. BMC Biology 20:18. doi: 10.1186/s12915-021-01210-1 (access to article)
Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife 9:e54518. doi: 10.7554/eLife.54518 (access to article)