Cancer ResearchDepartment of Thoracic Surgery

A Ghosh, M Riester, J Pal, KA Lainde, C Tangermann, A Wanninger, UK Dueren, S Dhamija, S Diederichs: “Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns”
Nature Communications (2024) 15: 9209

E Wassmer, G Koppàny†, M Hermes†, S Diederichs*, M Caudron-Herger*: "Refining the pool of RNA-binding domains advances the classification and prediction of RNA-binding proteins"
Nucleic Acids Research (2024) 52: 7504-7522

M Buckley, C Terwagne, A Ganner*, L Cubitt*, R Brewer*, DK Kim*, CM Kajba, N Forrester, P Dace, J De Jonghe, STC Shepherd, C Sawyer, M McEwen, S Diederichs, E Neumann-Haefelin, S Turajlic, EA Ivakine, GM Findlay: "Saturation Genome Editing Maps the Functional Spectrum of Pathogenic VHL Alleles"
Nature Genetics (2024) 56: 1446-1455

S Dhamija*, CM Yang*, J Seiler, K Myacheva, M Caudron-Herger, A Wieland, M Abdelkarim, Y Sharma, M Riester, M Groß, J Maurer, S Diederichs: "A Pan-Cancer Analysis reveals Nonstop Extension Mutations causing SMAD4 Tumor Suppressor Degradation"
Nature Cell Biology (2020) 22: 999-1010

M Gandhi, M Groß, JM Holler, SA Coggins, N Patil, JH Leupold, M Munschauer, M Schenone, CR Hartigan, H Allgayer, B Kim, S Diederichs: "The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer"
Nature Communications (2020) 11: 3214

M Caudron-Herger, E Wassmer, I Nasa, AS Schultz, J Seiler, AN Kettenbach, S Diederichs: "Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP"
Nature Protocols (2020) 15: 1338-1370

Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations"
Nature Communications (2019) 10: 2569

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation"
Molecular Cell (2019) 75: 184-199

M Polycarpou-Schwarz, M Groß, P Mestdagh, J Schott, SE Grund, C Hildenbrand, J Rom, S Aulmann, HP Sinn, J Vandesompele, S Diederichs: "The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation"
Oncogene (2018) 37: 4750-4768

A Goyal, K Myacheva, M Groß, M Klingenberg, B Duran-Arque, S Diederichs: "Challenges of CRISPR / Cas9 applications for long non-coding RNA genes"
Nucleic Acids Research (2017) 45: e12

S Diederichs et al.: "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations"
EMBO Molecular Medicine (2016) 8: 442-457

A Roth, S Diederichs: "RAP and ChIRP about X inactivation"
Nature (2015) 521: 170-171

T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR MacLeod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells"
Cancer Research (2013) 73: 1180-1189

 J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation"
Nature Cell Biology (2009) 11: 228-234
 
S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression"
Cell (2007) 131: 1097-1108
 
P Ji*, S Diederichs*, W Wang, S Böing, R Metzger, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "MALAT-1, a novel non-coding RNA, and Thymosin b4 predict Metastasis and Survival in early-stage Non-Small Cell Lung Cancer"
Oncogene (2003) 22: 8031-8041

... Here, you can find our Top Impact Publications independent of the research topic.

2024

A Ghosh, M Riester, J Pal, KA Lainde, C Tangermann, A Wanninger, UK Dueren, S Dhamija, S Diederichs: “Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns” Nature Communications (2024) 15: 9209

E Wassmer, G Koppàny†, M Hermes†, S Diederichs*, M Caudron-Herger*: "Refining the pool of RNA-binding domains advances the classification and prediction of RNA-binding proteins" Nucleic Acids Research (2024) 52: 7504-7522

M Buckley, C Terwagne, A Ganner*, L Cubitt*, R Brewer*, DK Kim*, CM Kajba, N Forrester, P Dace, J De Jonghe, STC Shepherd, C Sawyer, M McEwen, S Diederichs, E Neumann-Haefelin, S Turajlic, EA Ivakine, GM Findlay: "Saturation Genome Editing Maps the Functional Spectrum of Pathogenic VHL Alleles" Nature Genetics (2024) 56: 1446-1455

G Pelos, M Riester, J Pal, K Myacheva, I Moneke, JC Rotondo, M Lübbert, S Diederichs: "Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment" International Journal of Cancer (2024) 154: 1029-1042

2023

J Samarin*, P Fabrowski*, R Kurilov#, H Nuskova#, J Hummel-Eisenbeiss, H Pink, N Li, V Weru, H Alborzinia, U Yildiz, L Grob, M Taubert, M Czech, M Morgen, C Brandstädter, K Becker, L Mao, A Kumar Jayavelu, A Goncalves, U Uhrig, J Seiler, Y Lyu, S Diederichs, U Klingmüller, M Muckenthaler, A Kopp-Schneider, A Teleman, AK Miller, N Gunkel: “Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs” Redox Biology (2023) 62: 102639

K Myacheva, A Walsh, M Riester, G Pelos, J Carl, S Diederichs: "CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway" Cancer Letters (2023) 552: 215958

2022

V Rajagopal, AS Loubal, N Engel, E Wassmer, J Seiler, O Schilling, M Caudron-Herger, S Diederichs: "Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells" Cancers (Basel) (2022) 14: 6109

J Bartl, M Zanini, F Bernardi, A Forget, L Blümel, J Talbot, D Picard, N Qin, G Cancila, Q Gao, S Nath, IM Koumba, M Wolter, F Kuonen, M Langini, T Beez, C Munoz, D Pauck, V Marquardt, H Yu, J Souphron, M Korsch, C Mölders, D Berger, S Göbbels, FD Meyer, B Scheffler, B Rotblat, S Diederichs, V Ramaswamy, H Suzuki, A Oro, K Stühler, A Stefanski, U Fischer, G Leprivier, D Willbold, G Steger, A Buell, M Kool, P Lichter, SM Pfister, PA Northcott, MD Taylor, A Borkhardt, G Reifenberger, O Ayrault, M Remke: "The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors" Nature Communications (2022) 13: 4061

A Ghosh, K Myacheva, M Riester, C Schmidt, S Diederichs: "Chimeric oligonucleotides combining guide RNA and single-stranded DNA repair template effectively induce precision gene editing" RNA Biology (2022) 19: 588-593

S Taromi, E Firat, A Simonis, LM Braun, P Apostolova, M Elze, B Passlick, A Schumacher, S Lagies, A Frey, A Schmitt-Graeff, M Burger, K Schmittlutz, M Follo, D von Elverfeldt, X Zhu, B Kammerer, S Diederichs, J Duyster, MG Manz, G Niedermann*, R Zeiser*: "Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer" Cancer Letters (2022) 538: 215697

2021

J Pal*, AC Becker*, S Dhamija, J Seiler, M Abdelkarim, Y Sharma, J Behr, C Meng, C Ludwig, B Kuster, S Diederichs: "Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non-small cell lung cancer" Molecular Oncology (2021) 15: 1797-1817

M Caudron-Herger, RE Jansen, E Wassmer, S Diederichs: "RBP2GO: A comprehensive pan-species database on RNA-binding proteins, their interactions and functions" Nucleic Acids Research (2021) 49: D425-D436

R Onoguchi-Mizutani, Y Kirikae, Y Ogura, T Gutschner, S Diederichs, N Akimitsu: "Identification of Heat-Inducible Long Noncoding RNA MALAT1-Containing Novel Nuclear (HiNoCo) Body" Journal of Cell Science (2021) 134: jcs253559

2020

Q Hao*, X Zong*, Q Sun, YC Lin, YJ Song, S Hashemikhabir, RYC Hsu, M Kamran, R Chaudhary, V Tripathi, DK Singh, A Chakraborty, XL Li, YJ Kim, AV Orjalo, M Polycarpou-Schwarz, BS Moriarity, LM Jenkins, HE Johansson, YJ Zhu, S Diederichs, A Bagchi, TH Kim, SC Janga, A Lal, SG Prasanth, KV Prasanth: " The S phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway" eLIFE (2020) 9: e55102

Y Lyu, M Caudron-Herger, S Diederichs: "circ2GO: A Database Linking Circular RNAs to Gene Function" Cancers (2020) 12: 2975

S Dhamija*, CM Yang*, J Seiler, K Myacheva, M Caudron-Herger, A Wieland, M Abdelkarim, Y Sharma, M Riester, M Groß, J Maurer, S Diederichs: "A Pan-Cancer Analysis reveals Nonstop Extension Mutations causing SMAD4 Tumor Suppressor Degradation" Nature Cell Biology (2020) 22: 999-1010

M Gandhi, M Groß, JM Holler, SA Coggins, N Patil, JH Leupold, M Munschauer, M Schenone, CR Hartigan, H Allgayer, B Kim, S Diederichs: "The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer" Nature Communications (2020) 11: 3214

M Miladi*, M Raden*, S Diederichs, R Backofen: "MutaRNA: analysis and visualisation of mutation-induced changes in RNA structure" Nucleic Acids Research (2020) 48: W287-W291

L Merta, A Gandalovicova, V Cermak, M Dibus, T Gutschner, S Diederichs, D Rosel, J Brabek: "Increased Level of Long Non-Coding RNA MALAT1 Represents a Hallmark of Amoeboid Invasion" Cancers (2020) 12: 1136

N Van Der Steen*, Y Lyu*, AK Hitzler*, AC Becker, J Seiler, S Diederichs: "The circular RNA landscape of Non-Small Cell Lung Cancer Cells" Cancers (2020) 12: 1091

M Caudron-Herger, E Wassmer, I Nasa, AS Schultz, J Seiler, AN Kettenbach, S Diederichs: "Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP"  Nature Protocols (2020) 15: 1338-1370

2019

M Roatsch, I Hoffmann, M Abboud, R Hancock, H Tarhonskaya, KF Hsu, S Wilkins, TL Yeh, K Lippl, K Serrer, I Moneke, T Ahrens, D Robaa, S Wenzler, N Barthes, H Franz, W Sippl, S Lassmann, S Diederichs, E Schleicher, C Schofield, A Kawamura, R Schüle, M Jung: "The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases" ACS Chemical Biology (2019) 14: 1737-1750

Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations" Nature Communications (2019) 10: 2569

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation" Molecular Cell (2019) 75: 184-199

I Tiessen, M Abildgaard, M Lubas, H Gylling, C Steinhauer, E Pietras, S Diederichs, L Frankel, A Lund: "A high-throughput screen identifies the long noncoding RNA DRAIC as a regulator of autophagy" Oncogene (2019) 38: 5127-5141

S Dhamija, AC Becker, Y Sharma, K Myacheva, J Seiler, S Diederichs: "LINC00261 and the adjacent gene FOXA2 are epithelial markers and are suppressed during lung cancer tumorigenesis and progression" Non-coding RNA (2019) 5: E2

2018

A Roth, K Boulay, M Groß, M Polycarpou-Schwarz, FA Mallette, M Regnier, O Bida, D Ginsberg, A Warth, PA Schnabel, T Muley, M Meister, H Zabeck, H Hoffmann, S Diederichs: "Targeting LINC00673 expression triggers cellular senescence in lung cancer" RNA Biology (2018) 15: 1499-1511

Q Sun*, V Tripathi*^,#, JH Yoon^#, DK Singh, Q Hao, KW Min, S Davila, RW Zealy, XL Li, M Polycarpou-Schwarz, E Lehrmann, Y Zhang, KG Becker, SM Freier, Y Zhu, S Diederichs, SG Prasanth, A Lal, M Gorospe, KV Prasanth^#: "MIR-100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs" Nucleic Acids Research (2018) 46: 10405-10416

M Klingenberg, M Groß, A Goyal, M Polycarpou-Schwarz, T Miersch, AS Ernst, J Leupold, N Patil, U Warnken, H Allgayer, T Longerich, P Schirmacher, M Boutros, S Diederichs: "The lncRNA CASC9 and RNA binding protein HNRNPL form a complex and co-regulate genes linked to AKT signaling" Hepatology (2018) 68: 1817-1832

M Polycarpou-Schwarz, M Groß, P Mestdagh, J Schott, SE Grund, C Hildenbrand, J Rom, S Aulmann, HP Sinn, J Vandesompele, S Diederichs: "The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation" Oncogene (2018) 37: 4750-4768

G Dumbović, J Biayna, J Banús, J Samuelsson, A Roth, S Diederichs, S Alonso, M Buschbeck, M Perucho*, SV Forcales*: "A novel long non-coding RNA from NBL2 pericentromeric macrosatellite forms a perinucleolar aggregate structure in colon cancer" Nucleic Acids Research (2018) 46: 5504-5524

T Mlambo, S Nitsch, M Hildenbeutel, M Romito, M Müller, C Bossen, S Diederichs, T Cornu, T Cathomen, C Mussolino: "Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells" Nucleic Acids Research (2018) 46: 4456-4468

R Soares, G Maglieri, T Gutschner, S Diederichs, A Lund, B Nielsen, K Holmstrøm: "Evaluation of fluorescence in situ hybridization techniques to study long non-coding RNA expression in cultured cells" Nucleic Acids Research (2018) 46: e4

I Moneke, JT Kaifi, R Kloeser, P Samson, B Haager, S Wiesemann, S Diederichs, B Passlick: "Pulmonary metastasectomy for thyroid cancer as salvage therapy for radioactive iodine-refractory metastases" European Journal of Cardio-Thoracic Surgery (2018) 53: 625-630

M Caudron-Herger, S Diederichs: "Mitochondrial mutations in human cancer: Curation of translation" RNA Biology (2018) 15: 62-69

2017

A Goyal, E Fiskin, T Gutschner, M Polycarpou-Schwarz, M Groß, J Neugebauer, M Gandhi, M Caudron-Herger, V Benes, S Diederichs: "A cautionary tale of sense-antisense gene pairs: Independent regulation despite inverse correlation of expression" Nucleic Acids Research (2017) 45: 12496-12508

F Haderk, R Schulz, M Iskar, LL Cid, T Worst, KV Willmund, A Schulz, U Warnken, J Seiler, A Benner, M Nessling, T Zenz, M Göbel, J Dürig, S Diederichs, J Paggetti, E Moussay, S Stilgenbauer, M Zapatka, P Lichter, M Seiffert: "Tumor-derived exosomes modulate PD-L1 expression in monocytes" Science Immunology (2017) 2: eaah5509

L Nötzold, L Frank, M Gandhi, M Polycarpou-Schwarz, M Groß, M Gunkel, N Beil, H Erfle, N Harder, K Rohr, J Trendel, J Krijgsveld, T Longerich, P Schirmacher, M Boutros, S Erhardt, S Diederichs: "The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells" Scientific Reports (2017) 7: 2265

J Seiler, M Breinig, M Caudron-Herger, M Polycarpou-Schwarz, M Boutros, S Diederichs: "The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance" Nucleic Acids Research (2017) 45: 5458-5469

K Das, D Eisel, C Lenkl, A Goyal, S Diederichs, E Dickes, W Osen, SB Eichmüller: "Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system" PLoS ONE (2017) 12: e0174077

A Goyal, K Myacheva, M Groß, M Klingenberg, B Duran-Arque, S Diederichs: "Challenges of CRISPR / Cas9 applications for long non-coding RNA genes" Nucleic Acids Research (2017) 45: e12

2016

A Diaz-Lagares, A Crujeiras, P Lopez-Serra, M Soler, F Setien, A Goyal, J Sandoval, Y Hashimoto, A Martinez-Cardus, A Gomez, H Heyn, C Moutinho, J Espada, A Vidal, M Paúles, M Galan, N Sala, Y Akiyama, M Martínez-Iniesta, L Farré, A Villanueva, M Gross, S Diederichs, S Guil*, M Esteller*: "Epigenetic Inactivation of the p53-Induced Long Noncoding RNA TP53TG1 in Human Cancer" Proc Natl Acad Sci USA (2016) 113: E7535-7544

A Sas-Chen, MR Aure, L Leibovich, S Carvalho, Y Enuka, C Körner, M Polycarpou-Schwarz, S Lavi, N Nevo, Y Kuznetsov, J Yuan, F Azuaje, Oslo Breast Cancer Research Consortium (OSBREAC), I Ulitsky, S Diederichs, S Wiemann, Z Yakhini, VN Kristensen, AL Børresen-Dale, Y Yarden: "LIMT, a novel metastasis inhibiting lncRNA is suppressed by EGF and down-regulated in aggressive breast cancer" EMBO Molecular Medicine (2016) 8: 1052-1064

S Link*, S Grund*, S Diederichs: "Alternative splicing affects the subcellular localization of Drosha" Nucleic Acids Research (2016) 44: 5330-5343
 
K Nöske, HJ Stark, L Nevaril, M Berning, L Langbein, A Goyal, S Diederichs, P Boukamp: "Mitotic Diversity in homeostatic human interfollicular epidermis" International Journal of Molecular Sciences (2016) 17: 167 
 
J Haar, M Contrant, K Bernhardt, R Feederle, S Diederichs, S Pfeffer, HJ Delecluse: "The expression of a viral microRNA is regulated by clustering to allow optimal B cell transformation" Nucleic Acids Research (2016) 44: 1326-1341

2015

RM de Guia, AJ Rose, A Sommerfeld, O Seibert, D Strzoda, A Zota, Y Feuchter, A Krones-Herzig, T Sijmonsma, M Kirilov, C Sticht, N Gretz, G Dallinga-Thie, S Diederichs, N Klöting, M Blüher. M Berriel Diaz, S Herzig: "microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis" EMBO Journal (2015) 34: 344-360

2014

T Gutschner*, M Hämmerle*, N Pazaitis*, N Bley, E Fiskin, H Uckelmann, A Heim, M Groß, N Hofmann, R Geffers, B Skawran, T Longerich, K Breuhahn, P Schirmacher, B Mühleck, S Hüttelmaier*, S Diederichs*: "The Insulin-like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma" Hepatology (2014) 59: 1900-1911

L Quagliata, MS Matter, S Piscuoglio, L Arabi, C Ruiz, A Procino, M Kovac, F Moretti, Z Makowska, T Boldanova, JB Andersen, M Hämmerle, L Tornillo, MH Heim, S Diederichs, C Cillo*, LM Terracciano*: "IncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients" Hepatology (2014) 59: 911-923

D Nachmani, T Gutschner, A Reches, S Diederichs*, O Mandelboim*: "RNA binding proteins regulate the expression of the immune activating ligand MICB" Nature Communications (2014) 5: 4186

2013

M Liu, A Roth, M Yu, R Morris, F Bersani, MN Rivera, J Lu, T Shioda, S Vasudevan, S Ramaswamy, S Maheswaran, S Diederichs*, DA Haber*: "The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis" Genes & Development (2013) 27: 2543-2548 

J Winter, S Diederichs: "Argonaute-3 activates the let-7a passenger strand microRNA" RNA Biology (2013) 10: 1631-1643 

M Hämmerle*, T Gutschner*, H Uckelmann, S Ozgur, E Fiskin, M Groß, B Skawran, R Geffers, T Longerich, K Breuhahn, P Schirmacher, G Stoecklin, S Diederichs: "Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)" Hepatology (2013) 58: 1703-1712

M Eißmann, B Schwamb, IM Melzer, J Moser, D Siele, U Köhl, RJ Rieker, DL Wachter, A Agaimy, E Herpel, P Baumgarten, M Mittelbronn, S Rakel, D Kögel, S Böhm, T Gutschner, S Diederichs, M Zörnig: "A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes" PLoS ONE (2013) 8: e64873 

J Winter, S Link, D Witzigmann, C Hildenbrand, C Previti, S Diederichs: "Loop-miRs: Active microRNAs generated from single-stranded loop regions" Nucleic Acids Research (2013) 41: 5503-5512     

T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR Mac Leod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells" Cancer Research (2013) 73: 1180-1189

T Palm, K Hemmer, J Winter, I Fricke, K Tarbashevich, F Sadegi Shakib, I Rudolph, A Hillje, P De Lucca, L Bahnassawy, R Madel, T Viel, A de Siervi, A Jacobs, S Diederichs, J Schwamborn: "A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop" Nucleic Acids Research (2013) 41: 3699-3712

C Luo, PW Tetteh, PR Merz, E Dickes, A Abukiwan, A Hotz-Wagenblatt, S Holland-Cunz, T Sinnberg, B Schittek, D Schadendorf, S Diederichs, SB Eichmüller: "miR-137 inhibits the invasion of melanoma cells through down-regulation of multiple oncogenic target genes" Journal of Investigative Dermatology (2013) 133: 768-775

2012

M Faryna*, C Konermann*, S Aulmann, J Lorenzo Bermejo, M Brugger, S Diederichs, J Rom, D Weichenhan, R Claus, M Rehli, P Schirmacher, HP Sinn, C Plass, C Gerhäuser: "Genome-wide methylation screen in low-grade breast cancer to identify novel diagnostic and prognostic markers" FASEB Journal (2012) 26: 4937-4950 

M Eißmann*, T Gutschner*, M Hämmerle, S Günther, M Caudron-Herger, M Groß, P Schirmacher, K Rippe, T Braun, M Zörnig*, S Diederichs*: "Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development" RNA Biology (2012) 9: 1076-1087

SE Grund, M Polycarpou-Schwarz, C Luo, SB Eichmüller, S Diederichs: "Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells" Neoplasia (2012) 14: 238-248

A Heinemann, F Zhao, S Pechlivanis, J Eberle, A Steinle, S Diederichs, D Schadendorf, A Paschen: "Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D" Cancer Research (2012) 72: 460-471

2011

T Gutschner, M Baas, S Diederichs: "Non-coding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases" Genome Research (2011) 21: 1944-1954

J Winter, S Diederichs: "Argonaute proteins regulate microRNA stability" RNA Biology (2011) 8: 1149-1157

M Ganzinger, T Noack, S Diederichs, T Longerich, P Knaup: "Service-oriented Data Integration for a Biomedical Research Network" Studies in Health Technology and Informatics (2011) 169: 867-871

C Kahlert, F Klupp, K Brand, F Lasitschka, S Diederichs, J Kirchberg, N Rahbari, S Dutta, U Bork, J Fritzmann, C Reissfelder, M Koch, J Weitz: "Invasion front specific expression and prognostic significance of microRNAs in colorectal liver metastases" Cancer Science (2011) 102: 1799-1807

N Bäumer*, L Tickenbrock*, P Tschanter*, L Lohmeyer, S Diederichs, S Bäumer, BV Skryabin, F Zhang, S Agrawal-Singh, G Koehler, WE Berdel, H Serve, S Koschmieder, C Müller-Tidow: "Inhibitor of CDK interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling" Journal of Biological Chemistry (2011) 286: 28210-28222

2010

P de Souza Rocha Simonini*, A Breiling*, N Gupta, M Malekpour, M Youns, R Omranipour, F Malekpour, S Volinia, CM Croce, H Najmabadi, S Diederichs, Ö Sahin, D Mayer, F Lyko, JD Hoheisel, Y Riazalhosseini: "Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with Estrogen Receptor alpha in breast cancer cells" Cancer Research (2010) 70: 9175-9184

I Surolia*, SP Pirnie*, V Chellappa*, KN Taylor*, A Cariappa*, J Moya, H Liu, DW Bell, D Driscoll, S Diederichs, K Haider, I Netravali, S Le, R Elia, E Dow, A Lee, J Freudenberg, PL De Jager, Y Chretien, A Varki, ME MacDonald, T Gillis, TW Behrens, D Bloch, D Collier, J Korzenik, DK Podolsky, D Hafler, M Murali, B Sands, JH Stone, PK Gregersen, S Pillai: "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity" Nature (2010) 466: 243-247

2008

S Maheswaran*, LV Sequist*, S Nagrath*, L Ulkus, B Brannigan, C Collura, E Inserra, S Diederichs, AJ Iafrate, DW Bell, S Digumarthy, A Muzikansky, D Irimia, J Settleman, RG Tompkins, TJ Lynch, M Toner, DA Haber: "Detecting Epidermal Growth Factor Receptor Mutations in Circulating Tumor Cells from Patients with Non-Small Cell Lung Cancer" New England Journal of Medicine (2008) 359: 366-377

S Diederichs, S Jung, SM Rothenberg, GA Smolen, BG Mlody, DA Haber: "Co-expression of Argonaute-2 enhances RNA Interference towards perfect match binding sites" Proceedings of the National Academy of Sciences U.S.A. (2008) 105: 9284-9289

E Bulk, A Hascher, R Liersch, RM Mesters, S Diederichs, B Sargin, V Gerke, M Hotfilder, J Vormoor, WE Berdel, H Serve, C Müller-Tidow: "Adjuvant therapy with small hairpin RNA prevents NSCLC metastasis development in mice" Cancer Research (2008) 68: 1896-1904

2007

S Diederichs, DA Haber: "Dual Role for Argonautes in microRNA Processing and post-transcriptional Regulation of microRNA Expression" Cell (2007) 131: 1097-1108

GA Smolen, BJ Schott, RA Stewart, S Diederichs, B Muir, HL Provencher, AT Look, DC Sgroi, RT Peterson, DA Haber: "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors" Genes & Development (2007) 21: 2131-2136

P Ji, N Bäumer, T Yin, S Diederichs, F Zhang, C Beger, K Welte, S Fulda, WE Berdel, H Serve, C Müller-Tidow: "The DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells" International Journal of Cancer (2007) 121: 706-713

2006

S Diederichs, DA Haber: "Sequence Variations of microRNAs in human Cancer: Alterations in predicted secondary Structure do not affect Processing" Cancer Research (2006) 66: 6097-6104

2005

M Böhm, M Eickelmann, Z Li, SW Schneider, V Oji, S Diederichs, GS Barsh, A Vogt, K Stieler, U Blume-Peytavi, TA Luger: "Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of α-melanocyte-stimulating hormone in human dermal papilla cells" Endocrinology (2005) 146: 4635-4646

P Ji, S Agrawal, S Diederichs, N Bäumer, A Becker, T Cauvet, S Kowski, C Beger, K Welte, WE Berdel, H Serve, C Müller-Tidow: "Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells" Oncogene (2005) 24: 2739-2744

S Diederichs, N Bäumer, N Schultz, FK Hamra, MG Schrader, ML Sandstede, WE Berdel, H Serve, C Müller-Tidow: "Expression Patterns of Mitotic and Meiotic Cell Cycle Regulators in Testicular Cancer and Development" International Journal of Cancer (2005) 116: 207-217

C Müller-Tidow*, S Diederichs*, E Bulk, T Pohle, B Steffen, J Schwäble, S Plewka, M Thomas, R Metzger, PM Schneider, C Brandts, WE Berdel, H Serve: "Identification of Metastasis-associated Receptor Tyrosine Kinases in Non-Small Cell Lung Cancer" Cancer Research (2005) 65: 1778-1782

2004

C Müller-Tidow*, P Ji*, S Diederichs, J Potratz, C Beger, M Carrington, G Köhler, T Cauvet, A Yasmeen, E Bulk, HP Koeffler, WE Berdel, H Serve: "Cyclin A1 is induced by p53 following DNA damage and modulates DNA repair by interacting with Ku proteins" Molecular and Cellular Biology (2004) 24: 8917-8928

S Diederichs, E Bulk, B Steffen, P Ji, L Tickenbrock, K Lang, KS Zänker, R Metzger, PM Schneider, V Gerke, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "S100 family members and Trypsinogens are predictors of distant Metastasis and Survival in early-stage Non-Small Cell Lung Cancer" Cancer Research (2004) 64: 5564-5569

S Diederichs, N Bäumer, P Ji, SK Metzelder, GE Idos, T Cauvet, W Wang, M Möller, S Pierschalski, J Gromoll, MG Schrader, HP Koeffler, WE Berdel, H Serve, C Müller-Tidow: "Identification of Interaction Partners and Substrates of the Cyclin A1/CDK2 complex" Journal of Biological Chemistry (2004) 279: 33727-33741

C Müller-Tidow*, B Steffen*, T Cauvet, L Tickenbrock, P Ji, S Diederichs, B Sargin, G Köhler, M Stelljes, E Puccetti, M Ruthardt, S de Vos, SW Hiebert, HP Koeffler, WE Berdel, H Serve: "Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells" Molecular and Cellular Biology (2004) 24: 2890-2904

2003

P Ji*, S Diederichs*, W Wang, S Böing, R Metzger, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "MALAT-1, a novel non-coding RNA, and Thymosin b4 predict Metastasis and Survival in early-stage Non-Small Cell Lung Cancer" Oncogene (2003) 22: 8031-8041

C Müller-Tidow, C Readhead, AH Cohen, K Asotra, GE Idos, S Diederichs, T Cauvet, R Yang, WE Berdel, H Serve, HP Koeffler: "Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice" International Journal of Molecular Medicine (2003) 11: 311-315

C Müller-Tidow, S Diederichs, MG Schrader, U Vogt, K Miller, WE Berdel, H Serve: "Cyclin A1 is highly expressed in aggressive testicular germ cell tumors" Cancer Letters (2003) 190: 89-95

PM Sincock, IG Ganley, JP Krise, S Diederichs, U Sivars, B O’Connor, L Ding, SR Pfeffer: "Self-Assembly Is Important for TIP47 Function in Mannose 6-Phosphate Receptor Transport" Traffic (2003) 4: 18-25

2002

M Schrader, C Müller-Tidow, S Ravnik, M Müller, W Schulze, S Diederichs, H Serve, K Miller: "Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker" Human Reproduction (2002) 17: 2338-2343

2001

C Müller-Tidow, K Kügler, S Diederichs, S Klümpen, A Westermann, P Zuo, U Vogt, R Metzger, PM Schneider, WE Berdel, H Serve: "Loss of expression of HDAC-recruiting Methyl-CpG binding domain proteins in human cancer" British Journal of Cancer (2001) 85: 1168-1174

C Müller-Tidow, W Wang, GE Idos, S Diederichs, R Yang, C Readhead, WE Berdel, H Serve, M Saville, R Watson, HP Koeffler: "Cyclin A1 directly interacts with B-myb and Cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function" Blood (2001) 97: 2091-2097

C Müller-Tidow, R Metzger, K Kügler, S Diederichs, GE Idos, M Thomas, B Dockhorn-Dworniczak, PM Schneider, HP Koeffler, WE Berdel, H Serve: "Cyclin E is the Only Cyclin-dependent Kinase 2-associated Cyclin that Predicts Metastasis and Survival in Early Stage Non-Small Cell Lung Cancer" Cancer Research (2001) 61: 647-653

C Müller-Tidow, C Bornemann, S Diederichs, A Westermann, S Klümpen, P Zuo, W Wang, WE Berdel, H Serve: "Analyses of the genomic methylation status of the human Cyclin A1 promoter by a novel real-time PCR-based methodology" FEBS Letters (2001) 490: 75-79

2000

C Müller, C Readhead, S Diederichs, GE Idos, R Yang, N Tidow, H Serve, WE Berdel, HP Koeffler: "Methylation of the Cyclin A1 Promoter Correlates with Gene Silencing in Somatic Cell Lines, while Tissue-Specific Expression of Cyclin A1 is Methylation Independent" Molecular and Cellular Biology (2000) 20: 3316-3329

1999

C Müller, R Yang, GE Idos, N Tidow, S Diederichs, OM Koch, W Verbeek, TP Bender, HP Koeffler: "c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression" Blood (1999) 94: 4255-4262

M Caudron-Herger, S Diederichs: "Insights from the degradation mechanism of Cyclin D into targeted therapy of the cancer cell cycle" Signal Transduction & Targeted Therapy (2021) 6: 311

M Gandhi, M Caudron-Herger, S Diederichs: "RNA motifs and combinatorial prediction of non-coding RNA interaction, stability and localization" Nature Structural & Molecular Biology (2018) 25: 1070-1076

M Klingenberg, A Matsuda, S Diederichs*, T Patel*: "Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets" Journal of Hepatology (2017) 67: 603-618

S Diederichs, L Bartsch*, JC Berkmann*, K Fröse*, J Heitmann*, C Hoppe*, D Iggena*, D Jazmati*, P Karschnia*, M Linsenmeier*, T Maulhardt*, L Möhrmann*, J Morstein*, SV Paffenholz*, P Röpenack*, T Rückert*, L Sandig*, M Schell*, A Steinmann*, G Voss*, J Wasmuth*, ME Weinberger*, R Wullenkord*: "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations" EMBO Molecular Medicine (2016) 8: 442-457

S Dhamija, S Diederichs: "From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis" International Journal of Cancer (2016) 139: 269-280

A Roth, S Diederichs: "RAP and ChIRP about X inactivation" Nature (2015) 521: 170-171

A Roth, S Diederichs: "Long non-coding RNAs in lung cancer" Current Topics in Microbiology & Immunology (2016) 394: 57-110

S Diederichs: "micro-Terminator: 'Hasta la vista, lncRNA !' " Nature Structural & Molecular Biology (2015) 22: 279-281

G Stoecklin, S Diederichs: "tRNAs: New tricks from old dogs" EMBO Journal (2014) 33: 1981-1983

S Diederichs: "The four dimensions of non-coding RNA conservation" Trends in Genetics (2014) 30: 121-123

H Sültmann, S Diederichs: "Long non-coding RNA: LNCs to cancer" European Urology (2014) 65: 1152-1153

T Gutschner, M Hämmerle, S Diederichs: "MALAT 1 - a paradigm for long noncoding RNA function in cancer" Journal of Molecular Medicine (2013) 91, (7): 791-801

T Gutschner, S Diederichs: "The Hallmarks of Cancer: A long non-coding RNA point of view" RNA Biology (2012) 9: 703-719

S Diederichs: "Non-coding RNA and disease" RNA Biology (2012) 9: 701-702

SK Abd Ellatif, T Gutschner, S Diederichs: "Long Noncoding RNA Function and Expression in Cancer" in Regulatory RNAs, edited by Bibekanand Mallick & Zhumur Ghosh (2012) 197-226

J Winter*, A Roth*, S Diederichs: "RNA meets Disease in Paradise" RNA Biology (2011) 8: 984-987

J Winter, S Diederichs: "microRNA Northern Blotting, Precursor Cloning & Ago2-improved RNA interference" in Methods in Molecular Biology: microRNA & Cancer, edited by Wei Wu (2011) 85-100

J Winter, S Diederichs: "microRNA Biogenesis and Cancer" in Methods in Molecular Biology: microRNA & Cancer, edited by Wei Wu (2011) 3-22

S Grund, S Diederichs: "microRNA Biogenesis and its impact on RNA interference" in RNA Technologies and Their Applications, edited by VA Erdmann & J Barciszewski (2010) 325-354

S Diederichs: "Non-coding RNA in malignant tumors : A new world of tumor biomarkers and target structures in cancer cells" [German] Pathologe (2010) S2: 258-262

J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation" Nature Cell Biology (2009) 11: 228-234

C Müller-Tidow, S Diederichs, M Thomas, H Serve: "Genome wide screening for prognosis predicting genes in early stage non-small cell lung cancer" Lung Cancer (2004) 45: S145-S150

---

Asterisks (*) indicate shared first or last or corresponding authorship.
Authors in bold are present or former members of our labs.