Cancer ResearchDepartment of Thoracic Surgery

25.10.2024 - Published

Today, Avantika's manuscript on her high-throughput screen of all 2335 protein extensions emanating from nonstop mutations in cancer has been published - have a look: Nature Communications

Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns

07.10.2024 - Nobel Prize for microRNAs

Today, Gary Ruvkun and Victor Ambros have been awarded with the Nobel Prize for their discovery of the first microRNAs in the nematode C. elegans in 1993. Congratulations to these two researchers pioneering the field of small RNA biology!

Since also Sven made relevant contributions to the microRNA field in its early days (Cell 2007, Nature Cell Biology 2009, Nucleic Acids Research 2013, Genes & Development 2013, Nucleic Acids Research 2016), he was asked for expert comments on the relevance of microRNAs especially in cancer by a number of media outlets - here is a small selection:

Nobelpreis für Medizin: Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin | ZEIT ONLINE

Nobelpreis für Medizin - Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin - Wissen - SZ.de (sueddeutsche.de)

Nobelpreis für Medizin: Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin (tagesspiegel.de)

Nobelpreis für Genforschung: Doch kein genetischer Müll - das kann microRNA in der Medizin - n-tv.de

Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin (fr.de)

Warum microRNA in der Medizin so wichtig ist (stuttgarter-zeitung.de)

Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin - WELT

Nobelpreis für Medizin: Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin | STERN.de

Nobelpreis für Medizin: microRNA in der Medizin - [GEO]

Herzschwäche, Alzheimer, Krebs: microRNA in der Medizin | Kölner Stadt-Anzeiger (ksta.de)

09.09.2024 - Databases

Once in a while, it is good to see that the resources which we have provided to the scientific community are heavily used - so we checked today whether our databases are actually frequently used and we are delighted to see that they are:

42922 visitors: NonStopDB - Database for nonstop extension mutations, a.k.a. stop-loss mutations, in cancer

34148 visitors: SynMICdb - Database for synonymous mutation in cancer

29839 visitors: RBP2GO & RBP2GO 2.0 - Database for RNA-binding proteins

14681 visitors: R-DeeP & R-DeeP 2.0 - Database for the proteome-wide identification of RNA-dependent proteins in HeLa and A549 cancer cells

Thank you for your large interest in our work - keep using them and please cite them if they are helpful for your research.

08.08.2024 - Accepted

Today, we are delighted that Nature Communications has accepted in principle Avantika's manuscript on her high-throughput screen of all 2335 protein extensions emanating from nonstop mutations in cancer. Have a look at the paper to see the surprisingly broad functional impact that many nonstop extension - a.k.a. stop-loss - mutations have and the role that C-terminal hydrophobicity plays for the destabilization of tumor suppressor genes.

06.06.2024 - Accepted

Elsa's manuscript on the relevance of RNA-bindings domains (RBDs) and RNA-related family IDs (RfamIDs) to refine the pool of RNA-binding proteins across species has today been accepted for publication in Nucleic Acids Research.
First, we congratulate and thank everyone involved in this study.
Next, we are also happy to announce that this study also comes with a major update of the RBP2GO database for RNA-binding proteins (RBP2GO 2.0) as well as a new RBP2GO Composite Score to characterize the likelihood of a protein to be an RNA-binding protein. You can find the database already here: https://RBP2GO-2-Beta.dkfz.de .

25.05.2024 - Mutational Scanning Symposium 2024

Coming back from the Mutational Scanning Symposium 2024 - at the Broad Institute in Boston this year... leaving us inspired and corroborating our path in Functional Cancer Genomics to match not genes and drugs, but individual mutations and drugs for successful and precise personalized oncology.

13.05.2024 - Welcome

In addition to the good news from Nature Genetics, we have another reason to be happy about:

Welcome to Kadri-Ann - again - who joins us again for her Bachelor Thesis !

All the best wishes - we look forward to some productive weeks with some exciting new data about FGFR.

13.05.2024 - Accepted

Good news from London !!!
Our joint study with Greg Findlay from The Francis Crick Institute in London - to which we contributed together with Athina Ganner and Elke Neumann-Haefelin from the Nephrology Department - has today been accepted for publication in Nature Genetics. We are delighted to see another study on functional cancer genomics in press.

25.03.2024 - Lab-Outing ... but no quiz

The new year has started ... an brought some new and exciting data and manuscripts to be written... so we took an evening for a lab-outing. The pub quiz was already packed, so we moved on in the Freiburg Old Town and found a very nice dinner place with Turkish food.

19.12.2023 - Lab-Outing Darts

The rain gets colder: holiday season is coming up ! For our christmas lab outing, we all go for dinner & darts tonight.

01.12.2023 - Welcome !

Today, we are happy to (finally) welcome Yagmur Öykü Carus to our lab as a new graduate student. For her PhD, she will explore the functional impact and the druggability of FGFR point mutations in high throughput.

28.11.2023 - Lab-Outing Einstein & FreiSpiel

Tonight, we will celebrate Sven's birthday at Cafe Einstein and then move to FreiSpiel for the rest of the evening.

16.11.2023 - EMBO Cancer Genomics

Today, Carla presents her exciting project on the druggability of FGFR point mutations in a talk at the EMBO Cancer Genomics Meeting in Heidelberg.

18.10.2023 - Lab-Outing Bowling

Cancer Research goes Bowling tonight...

10.10.2023 - Accepted

Great news: Giulia's paper on the combination of DNA demethylation with ATRA to treat lung cancer cells has been accepted today for publication by the International Journal of Cancer!

01.10.2023 - MOTI-VATE

Today, the new class of the prestigious MOTI-VATE program for medical students starts and we are very happy to report that Luise Viardot, an M.D. student in our lab, has been selected this year and is supported by the program.

05.09.2023 - Lab-Outing FreiSpiel

We are resuming our lab outings after the pandemic... fine Indian food for dinner and then exciting games at FreiSpiel.

25.07.2023 - Dr. Giulia Pelos

It's a PhD ! Congratulations to Giulia for successfully defending her PhD today - and all the best wishes for her future postdoc at a renown institute in the UK !

20.07.2023 - Science Slam

Congratulations to Avantika - she has won the third place in the ZTZ + IMITATE Science Slam 2023 !

15.06.2023 - Welcome !

Today, we welcome Angela Wanninger as a new technician to our lab. 

01.05.2023 - The Scientist - Synonymous Mutations in Cancer

Again, our research has attracted international attention:

Today, an article about synonymous mutations in cancer appeared in the popular science journal The Scientist - and we are happy for the increased visibility of this important, but under-researched topic of non-canonical mutations.

01.03.2023 - The Scientist - Long non-coding RNA & Microproteins in Cancer

Today, an article about our research on long non-coding RNAs and microproteins in cancer appeared in the popular science journal The Scientist.

16.02.2023 - Accepted

Our collaboration partner Nicolas Gunkel sends good news: our manuscript entitled "Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs" has been accepted for publication in Redox Biology.

19.12.2022 - Christmas Market

After all these Corona years, we look forward to our christmas outing tonight - a visit to Freiburg's Christmas Market followed by a nice dinner right next to the Freiburger Münster.

07.12.2022 - Accepted

The manuscript from Varshni and Astrid has been accepted for publication in Cancers today describing the proteome-wide screening for RNA-dependent proteins in lung cancer cells using the R-DeeP approach. The data is also available in our updated R-DeeP2 database.

31.10.2022 - Farewell

The end of an era - Ksenia, one of the founding members of our lab in Freiburg moves on to new challengs after successful publication of her paper and defence of her PhD. We thank her for all that she has done in and for our group and wish her all the best for the bright future ahead of her.

10.10.2022 - Accepted

Great news from Cancer Letters: Ksenia's paper on CRISPRi screening for coding and non-coding essentiality factors has been accepted for publication! The most exciting finding is the role of the protein CASP8AP2 in lung cancer cells.

26.-28.09.2022 - Retreat

Not in the lab these days ... the Diederichs' labs from Heidelberg and Freiburg spend their retreat in Monastery Bühl to discuss new ideas and plan exciting new projects.

11.04.2022 - Accepted

Today, Avantika's paper on the use of chimeric oligonucleotides merging the guide RNA and the repair template for precision genome editing using CRISPR to introduce specific point mutations has been accepted for publication in RNA Biology. Congratulations and thank you to everyone who contributed to this project!

27.10.2021 - Dr. Myacheva

Congratulations to Ksenia, who successfully defended her PhD today!

...and we celebrate with a lab "meeting" in Heidelberg from the DKFZ to the philosophers' path to the old town...

18.10.2021 - Pub Quiz

Our entire group joined forces in the Pub Quiz of O'Kelly's in Freiburg... and we made third place among 38 teams, so congratulations and thanks to everyone who joined and answered tricky questions from Charles Montgomery Burns to Franz Ferdinand.

07.07.2021 - Grants nonstop

Good news from the DFG:

Our research proposal on studying the role of nonstop extension mutations in tumor suppressor genes has been fully granted!

We are looking forward to continue our work on this novel class of mutations in cancer for another three years which started with our discovery of them in the tumor suppressor gene SMAD4 (Dhamija et al., Nat Cell Biol 2020).

If you are also interested in this mutation class, also visit our database NonstopDB.

07.04.2021 - Good news "migrates"...

Good news from "Molecular Oncology":
Today, our study on novel factors in lung cancer cell migration using the "MigExpress" approach has been accepted for publication.
Congratulations and many thanks to everyone who contributed - especially to the first authors Jagriti and Andrea!

31.12.2020 - 5 x 1000

At the end of this year, we are happy to learn that the Web of Science now lists five of our publications with more than 1000 citations: our discovery of the important functional role of the long non-coding RNA MALAT in lung cancer metastasis has now also reached this level. 

We would like to thank all our fellow researchers for their interest and acknowledging our work by frequently citing us.

Also, all our publications have been again cited far more than 1000 times in the year 2020 for the sixth year in a row.

Here are the five most frequently cited front runners with more than 1000 citations each:

T Gutschner, M Hämmerle, M Eißmann, J Hsu, Y Kim, G Hung, AS Revenko, G Arun, M Stentrup, M Groß, M Zörnig, AR MacLeod, DL Spector, S Diederichs: "The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells"
Cancer Research (2013) 73: 1180-1189

P Ji*, S Diederichs*, W Wang, S Böing, R Metzger, PM Schneider, N Tidow, B Brandt, H Buerger, E Bulk, M Thomas, WE Berdel, H Serve, C Müller-Tidow: "MALAT-1, a novel non-coding RNA, and Thymosin b4 predict Metastasis and Survival in early-stage Non-Small Cell Lung Cancer"
Oncogene (2003) 22: 8031-804

J Winter*, S Jung*, S Keller, RI Gregory, S Diederichs: "Many roads to maturity: microRNA biogenesis pathways and their regulation"
Nature Cell Biology (2009) 11: 228-234

T Gutschner, S Diederichs: "The Hallmarks of Cancer: A long non-coding RNA point of view"
RNA Biology (2012) 9: 703-719

S Maheswaran*, LV Sequist*, S Nagrath*, L Ulkus, B Brannigan, C Collura, E Inserra, S Diederichs, AJ Iafrate, DW Bell, S Digumarthy, A Muzikansky, D Irimia, J Settleman, RG Tompkins, TJ Lynch, M Toner, DA Haber: "Detecting Epidermal Growth Factor Receptor Mutations in Circulating Tumor Cells from Patients with Non-Small Cell Lung Cancer"
New England Journal of Medicine (2008) 359: 366-377

24.12.2020 - Happy holidays

Dear friends and colleagues:

We would like to wish you all happy holidays and all the best for the new year 2021.

While we all faced challenges during the corona pandemic this year and certainly all hope for a better year in 2021, we are also happy and a little proud to report, that we had scientifically a very productive and fruitful year of 2020 with high-rankling publications, lots of exciting new data and a patent application filed - so, we would like to thank everyone who supported us and contributed to our research.

17.10.2020 - Accepted

Nucleic Acids Research has accepted our manuscript on the RBP2GO database today for the next database issue in 2021.
Congratulations to Maiwen, Elsa & Ralf for creating this great resourse... have a look and find out a ot about RNA-binding proteins, their properties, their identification in more than a 100 datasets from 13 different species as well as their association with molecular mechanisms, biological processes and cellular components.

12.10.2020 - Two in one day ... Accepted

Two papers accepted in one day:

Congratulations to Yanhong for his manuscript on the new database circ2GO linking circular RNA expression, gene ontology and microRNA binding sites, which has been accepted for publication in Cancers today.
Perfect timing - since we need to say farewell to Yanhong next week.

More good news come from our collaboration partner Kannanganattu Prasanth from Illinois: the paper on the long non-coding RNA SUNO1 and its role in cell cycle progression has been accepted today by eLIFE. Congratulations, as well!

27.07.2020 - Publication in Nature Cell Biology

And here it is:

Today, Nature Cell Biology has published our study on nonstop extension mutations in human cancer and their exemplary effect on the tumor suppressor gene SMAD4, where nonstop extensions found in pancreatic and colon cancer patients lead to the complete loss of the protein due to proteasomal degradation via a degron in the C-terminal extension of mutated protein.

With this publication, our series of publications has reached another peak - with five publications in renown journals within the last 13 months:

S Dhamija*, CM Yang*, J Seiler, K Myacheva, M Caudron-Herger, A Wieland, M Abdelkarim, Y Sharma, M Riester, M Groß, J Maurer, S Diederichs: "A Pan-Cancer Analysis reveals Nonstop Extension Mutations causing SMAD4 Tumor Suppressor Degradation"
Nature Cell Biology (2020) epub

M Gandhi, M Groß, JM Holler, SA Coggins, N Patil, JH Leupold, M Munschauer, M Schenone, CR Hartigan, H Allgayer, B Kim, S Diederichs: "The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer"
Nature Communications (2020) 11: 3214

M Caudron-Herger, E Wassmer, I Nasa, AS Schultz, J Seiler, AN Kettenbach, S Diederichs: "Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP"
Nature Protocols (2020) 15: 1338-1370

Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations"
Nature Communications (2019) 10: 2569

M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation"
Molecular Cell (2019) 75: 184-199

26.06.2020 - Accepted !!!!!

Finally, a two year journey comes to a fruitful end:

Today, our manuscript on nonstop mutations in cancer has been accepted for publication in Nature Cell Biology.

We are thrilled and relieved and congratulate all participants and authors on the study lead by Sonam Dhamija... with special recognition going to Jeanette for the last strenous rounds of revisions.

05.06.2020 - Accepted

Again, good news - and a paper celebration via videoconferencing:

Nature Communications has accepted our study on a novel lncRNA called lincNMR, which regulates nucleotide metabolism via its interaction with YBX1 and regulating essential factors for dNTP synthesis like RRM2, TK1 or TYMS.

Congratulations to Minakshi - and all the best for her postdoc in the USA.

Additionally, also our collaboration partners could report the acceptance of two original articles in Nucleic Acids Research on the MutaRNA tool for RNA structure prediction of single nucleotide mutations and in Cancers on the role of MALAT1 in amoeboid migration.

23.04.2020 - Accepted

Our manuscript on the landscape of circular RNAs in lung adenocarcinoma has been accepted today for publication in Cancers.

Congratulations to the entire circRNA in lung cancer team - especially to the three shared first authors Nele, Yanhong and Anne!

08.03.2020 - Award for R-DeeP

Another great honor for our lab - and especially for Dr. Maiwen Caudron-Herger, the first author of the R-DeeP paper published in Molecular Cell in 2019:

Out of 413 applications, Maiwen and the R-DeeP paper have been selected for the

2020 SCBT Investigator Award

This award is given out only once per year based on scientific significance, scientific impact, experiment design and publication quality - so we feel truly honored that our paper was selected and congratulate Maiwen wholeheartedly!

Further projects in our lab successfully pursue our novel concept of RNA dependence. We find and characterize the impact of RNA in unexpected processes in the cell. If you are interested in the method, please also consult our recent detailed protocol published in Nature Protocols.

24.02.2020 - R-DeeP Protocol published

Today, our Nature Protocol for the R-DeeP approach to study RNA-dependent proteins has finally appeared online which should enable researchers around the world to successfully use this method and analyze the data obtained:

Nature Protocols - R-DeeP

31.01.2020 - Welcome & Farewell

Yesterday, we said farewell to Nele - and wish her all the best for her future endeavors in Belgium...and of course, we all look forward to see her joint manuscript with Yanhong and Anne published in the near future.

On the other hand, we welcome Giulia back in our lab as a graduate student who will focus on epigenetic therapy options for lung cancer jointly with the lab of Michael Lübbert: Welcome & all the best !

08.12.2019 - Funded

Excellent news for our project on RNA-dependent functions in the Cancer cell:

Today, we received a positive funding decision from the German Cancer Aid (Deutsche Krebshilfe) !

PhD student applications interested in the molecular analysis of RNA-dependent proteins in cancer are welcome.

29.10.2019 - Accepted

Good news from Nature Protocols today: we are happy that we can share our detailed R-DeeP protocol for the identification of RNA-dependent proteins including the experimental approach as well as the bioinformatic analysis with the scientific community!

Thanks to Maiwen and everyone who has contributed to this publication!

30.08.2019 - Farewell

Today, we sadly say goodbye to Sonam with a lab outing to the city with guests from Heidelberg and alumni - all came to wish all the best to Sonam as founding member of our Freiburg lab. Thank you for all your hard work, your excellent ideas, your help to so many projects and your inspiration !  

09.07.2019 - Accepted

Our collaboration partner Manfred Jung sends good news: our cooperative manuscript on a novel Jumonji inhibitor has just been accepted for publication in ACS Chemical Biology. Congratulations !

16.05.2019 - Accepted

Again - excellent news:

Our manuscript on synonymous mutations in cancer has just been accepted for publication in Nature Communications !

Thanks to all contributors to this study - both, from our lab as well as from the Backofen lab in Freiburg.

Please check out the associated database SynMICdb to find and analyze synonymous mutations in a pan-Cancer panel.

17.04.2019 - Lab Outing

"FR 04" - formerly known as "L666" or simply "our lab" - is out again:
Today, we go to the exciting place of Denzlingen and play Minigolf with 3D glasses on under black light... this is not only great fun, but also guarantees a number of great pictures of our group. 
Afterwards, we take advantage of now having a "true Italian" in our midst and go for an authentic Italian dinner.

11.04.2019 - Accepted

And here is a big one:

Our manuscript on RNA Dependence has just been accepted for publication in Molecular Cell !

We are very happy and look forward to pursuing this new concept of RNA-dependent protein complexes further in the near future - job advertisements will be coming up...

CONGRATULATIONS first and foremost to Maiwen, who drives this project successfully, but also to all other contributors to the R-DeeP project in our lab as well as our collaboration partner in Dartmouth, Arminja Kettenbach, and her team.

You can already use our database to look for your favorite protein and its RNA Dependence in the R-DeeP database. This also mprovides a comprehensive resource for studies of RNA-binding proteins compiling results from 19 studies in one user-friendly spot.

Stay tuned - there will hopefully be more soon...

04.03.2019 - Accepted

News from Copenhagen: together with our collaboration partner Anders Lund, we just published a study about lncRNAs linked to autophagy in Oncogene - congratulations to Anders and his team.

24.12.2018 - Happy Holidays

Happy holidays and all the best wishes for the new year - to everyone interested in and contributing to and generously supporting our research to understand the RNA biology of lung Cancer and tumor genetics.

18.12.2018 - Christmas Lab Outing

One week to go - so, we also go on our Christmas Lab Outing. This year, we go Bowling and have dinner in between the strikes and spares. And one of our future lab members even won a game...

17.12.2018 - Accepted

Sonam's study about the role of the lncRNA linc00261 and its neighboring gene FOXA2 in lung cancer development and metastasis as well as in epithelial-to-mesenchymal transition (EMT) and lung cancer cell migration has been accepted in the new pertinent journal in our field: Non-coding RNA. Congratulations !

28.11.2018 - Magical Lab Outing

Tonight, we will watch the second part of the Magical Creatures in 3D and then have a drink on Sven's birthday last week. Lucky us that we have Ksenia, who can enlighten us and fill us in on the details we missed in the movie... 

17.11.2018 - Accepted

The end of a long journey: Anna's manuscript on the role of linc00673 in lung cancer cell senescence has been accepted today at RNA Biology - congratulations and thanks to everyone who contributed over the years.

01.11.2018 - Microprotein CASIMO1 in Breast Cancer ... quite some attention

Just three months ago, we published our study on the functional role of the microprotein CASIMO1 in breast cancer (Oncogene 2018).
Within this short period, the article has already received a lot of attention ranking in th 96th percentile of similarly aged publications:http://www.nature.com/articles/s41388-018-0281-5/metrics

Moreover, a figure from the CASIMO1 paper has been selected as "Picture of the Week" by Bild der Wissenschaft: https://www.wissenschaft.de/bildervideos/bild-der-woche/gruene-winzlinge-befeuern-krebs/ .

15.10.2018 - Accepted

19. - 21.09.2018 - Retreat in the Black Forest

17.09.2018 - 1000th citation of MALAT1

12.09.2018 - Publon Awards for Peer Review

31.07.2018 - MALAT1 - the first ncRNA in the Cancer Gene Census

19.07.2018 - Accepted

14.05.2018 - Accepted

10.04.2018 - Lab Inning

02.04.2018 - Accepted

21.03.2018 - Accepted

28.02.2018 - Lab Outing & Farewell of a Master

26.02.2018 - Accepted - 10 points for CCI + CCCF

20.01.2018 - 500 citations for MALAT1

24.12.2017 - Happy holidays

13.12.2017 - Farewell & Christmas Lab Outing

11.12.2017 - Funding

08.12.2017 - Top 0.01%

24.11.2017 - Lab outing to the space

08.11.2017 - Visibility & Impact

19.10.2017 - ZTZ Happy Hour

04.10.2017 - Accepted

02. - 04.10.2017 - Retreat

02.10.2017 - Accepted

21.09.2017 - Accepted

12.09.2017 - Publons Peer Review Award

24.08.2017 - Accepted

26.06.2017 - Welcome

13.04.2017 - Accepted

10.04.2017 - Accepted

01.03.2017 - One year in Freiburg

01.02.2017 - Lab Outing

25.01.2017 - Accepted

01.01.2017 - A new year

24.12.2016 - Happy holidays

16.12.2016 - 1000 Citations

14.12.2016 - Lab Outing ... to the Movies

05.12.2016 - Christmas Lab Outing

22.11.2016 - Celebrations

24.10.2016 - Welcome

12.10.2016 - Accepted

23.09.2016 - Accepted

Today, our manuscript on the use of CRISPR-based technologies for non-coding RNAs (as well as any other gene ...) -  the challenges and potential pitfalls as well as the required controls to circumvent these  - has been accepted by Nucleic Acids Research!

Congratulations to Ashish and Ksenia as well as Matthias and Marcel - and many thanks to everyone else who contributed to this quick and successful Project.

21.09.2016 - Vacant position for technician

Job opening !!! Please have a look at our site "Open Positions"... 

10.08.16 - Lab Outing

After our lab meeting today, we will go for our August lab outing... if you want to discuss science and beyond, you can meet uns in the "Extrablatt" tonight...

28.07.16 - Lab Inning

The Lab Outing for July is more a Lab Inning: our latest addition to the lab comes to visit. Sadly, there are no lab coats in size 50 for toddlers...

27.07.16 - FEBS Anniversary Prize

And another recognition of our research work: today, the Federation of European Biochemical Societies (FEBS) has awarded Sven with the 2016 Anniversary Prize!

09.06.16 - New future lab member arrived...

Congratulations!

04.06.16 - Accepted

Good news from our collaboration partners in Israel, Aldema Sas-Chen and Yosef Yarden: our manuscript on the role of LIMT, a novel lncRNA that inhibits metastasis in breast cancer, got accepted in EMBO Molecular Medicine. Congratulations!

25.05.16 - Birthday Lab Outing

This month's lab outing is something special: we celebrate (into) Ksenia's birthday! Karma in Freiburg - known to many, but not yet to us will host us for the evening.

18.05.16 - Housewarming, part II

After the official opening ceremony and the housewarming party for the entire building, we will now have the second part of the housewarming activities... with a much more selective group of attendees: the left half of the second floor... come and join in. 

11.05.16 - Sonam's review published

Sonam's review on the role of lncRNAs in migration, invasion and metastasis was published in the International Journal of Cancer.

10.05.16 - Dinner

After an intense day and the shock in the middle of the seminar, we earned our dinner and test out the Mexican restaurant next door... good food, but since there was a large group ahead of us, we had to wait for a long time before we could get back to the lab.

10.05.16 - Seminar at SFB 992

Today, Sven presents our projects at the SFB 992 "Medical Epigenetics" here in Freiburg.

Surprise right in the middle of the presentation: Sven's computer dies... an improvised Q&A session and a quick replacement from Ksenia save the seminar...

03.05.16 - "Ein klein Deutschkurs"

A surprise in the morning... a seminar in German for our international lab, but we took as "ein klein Deutschkurs"... and repeated the content of the instructions later in our lab Meeting in English.

02.05.16 - Cell culture

After the equipment of our lab is now almost complete and we spent the last months with a lot of planning and bioinformatical analyses for our running projects, we have started the cell culture today. Finally, our lab is fully operational.

29.04.16 - Accepted

Good news from our partner lab at the DKFZ: Nucleic Acids Research has accepted our manuscript on splicing isoforms of the microRNA processing factor Drosha for publication. Congratulations to Steffen and Steffi, the shared first authors of this story!

22.04.16 - ZTZ Housewarming

The Center for Translational Cell Research (ZTZ) will celebrate housewarming today! All members of this new center join for short presentations from each group in the building, a rallye through the ZTZ and an evening with food, music, dancing and GATTACA (geneticists will know why the title is in capital letters).

20.04.16 - Research Meeting Thoracic Surgery

The Department of Thoracic Surgery meets today in the ZTZ lecture hall for its research meeting. Members of the new division and clinical fellows present and discuss their latest exciting results from basic science and clinical studies.

13.04.16 - Lab Outing: Bowling

A new month - a new lab outing. Tonight, we will all go Bowling since this is not that far from the lab. Now, everyone knows Sven's story about the Homer Simpson bowling socks ... and who can really master thie pins.

01.04.16 - Welcome

Dr. Chul-Min Yang from the NIH joins us today as a new postdoctoral fellow: Welcome!

10.03.16 - Lab Outing March

Our first - of hopefully many - lab outings is taking place. Since many of us are new to Freiburg, we enjoy a guided tour through the old town followed by a nice dinner in town.

05.03.16 - Chairs

The title says it all... little things can make us very happy these days.

03.03.16 - SGBM

Today, Sven has been appointed as principal investiogator in the Spemann Graduate School of Biology and Medicine (SGBM).

01.03.16 - Start reloaded

Now, the new building of the ZTZ at Breisacher Str. 115 in Freiburg is indeed move-in ready (for the largest part) and our group really starts: Sven, Sonam and Ksenia join from the DKFZ in Heidelberg and Andrea Becker joins the lab as a new member while Olga Mayer has already been part of the Department of Thoracic Surgery.

At the top of our wish list yet to come: chairs!

17.02.16 - Accepted

Now, it is for everyone to see what Sven did last summer:

He was leading a group of 22 talented students from all life sciences in a summer academy organized jointly by the German Academic Scholarship Foundation and the Young Academy held at the Moastery of Roggenburg. Within only one week, they searched through more than 2100 scientific publications to distill the first of its kind review article on the topic of "The dark matter of the cancer genome: Aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations". Today, this manuscript has been accepted for publication in the journal EMBO Molecular Medicine.

04.02.16 - Accepted

Today, Sonam's review on the role of lncRNAs in migration, invasion and metastasis was accepted for publication in the International Journal of Cancer. Congratulations!

15.01.16 - SFB 850 Cell Migration

Sonam presents her project on the role of lncRNAs in cell migration, metastasis and EMT at the SFB 850 "Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis". Congratulations on a successful presentation!

01.01.16 - Start

Today, is officially the first day of the new Division of Cancer Research in the Department of Thoracic Surgery at the Medical Faculty and Medical Center of the University of Freiburg.

But... no space for us, so the "real" start of our division will be in March when the brandnew building will hopefully be move-in ready.