SARS-CoV-2: Freiburg-COVID-19 consortium
The SARS-CoV-2 epidemic has spread rapidly throughout the world since first emerging in Wuhan, China in late 2019. Although clinicians and researchers have been reporting new insights into the disease now termed COVID-19 at an unprecedented rate, many fundamental questions surrounding the underlying biology of the disease remain unanswered. Owing to its unique proximity to many other countries, the Upper Rhine region rapidly emerged as one of the earliest sites of viral transmission in Germany. As the major medical center in the area, the University Medical Center Freiburg has been a focus of patient diagnosis and care, establishing robust diagnostic workflows very early in the epidemic and treating severely ill patients in the region. The Freiburg-COVID-19 consortium is comprised of physicians and researchers from the Clinic for Internal Medicine II (Prof. Robert Thimme and Dr. Maike Hofmann) and the Institute of Virology (Prof. Dr. Marcus Panning, Prof. Dr. Georg Kochs and Prof. Dr. Martin Schwemmle) of the University Medical Center Freiburg. These two facilities have been collaborating for many years on the diagnosis, treatment, epidemiology, prevention and research of infectious diseases. The aim of the Freiburg-COVID-19 consortium is to provide an in-depth analysis of the ongoing pandemic and to provide insights into several key characteristics of SARS-CoV-2 infection which remain unclear.
Publications
- Vaccines (Basel) . 2024 Nov 1;12(11):1249.doi: 10.3390/vaccines12111249.
Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma
Khalid Shoumariyeh, Benedikt Csernalabics, Elahe Salimi Alizei, Matthias Reinscheid, Sebastian Giese, Kevin Ciminski, Georg Kochs, Martin Schwemmle, Julia Lang-Meli, Michelle Maas, Natascha Roehlen, Vivien Karl, Anne Graeser, Oezlem Sogukpinar, Ivana von Metzler, Denise Grathwohl, Leo Rasche, Holger Hebart, Miriam Kull, Florian Emmerich, Cornelius Florian Waller, Justus Duyster, Monika Engelhardt, Tanja Nicole Hartmann, Bertram Bengsch, Tobias Boettler, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Hendrik Luxenburger
- Nat Commun. 2023 Apr 10;14(1):1999.doi: 10.1038/s41467-023-37591-w.
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G Wrobel, Andrea B Grawitz, Philipp Nawrath, Stephen R Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
- Nat Commun. 2022 Sep 26;13(1):5654.doi: 10.1038/s41467-022-32867-z.
Circulating multimeric immune complexes contribute to immunopathology in COVID-19
Jakob Ankerhold, Sebastian Giese, Philipp Kolb, Andrea Maul-Pavicic, Reinhard E Voll, Nathalie Göppert, Kevin Ciminski, Clemens Kreutz, Achim Lother, Ulrich Salzer, Wolfgang Bildl, Tim Welsink, Nils G Morgenthaler, Andrea Busse Grawitz, Florian Emmerich, Daniel Steinmann, Daniela Huzly, Martin Schwemmle, Hartmut Hengel, Valeria Falcone
- J Exp Med. 2022 Dec 5;219(12):e20220621.doi: 10.1084/jem.20220621. Epub 2022 Sep 21.
Impaired immune response drives age-dependent severity of COVID-19
Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker, Benedikt Sachs, Lisa Kern, Miriam Llorian, Nadine Ebert, Fabien Labroussaa, Tran Thi Nhu Thao, Bettina Salome Trueeb, Joerg Jores, Volker Thiel, Martin Beer, Jonas Fuchs, Georg Kochs, Andreas Wack, Martin Schwemmle, Daniel Schnepf
- Nat Commun. 2022 Aug 8;13(1):4631.doi: 10.1038/s41467-022-32324-x
COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation
Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David B Reeg, Valerie Oberhardt, Natascha Roehlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
- J Allergy Clin Immunol Pract 2022 Jun 29;S2213-2198(22)00642-0.doi: 10.1016/j.jaip.2022.06.020
Passive immunization against COVID-19 by anti-SARS-CoV-2 spike IgG in commercially available immunoglobulin preparations in severe antibody deficiency
Julia R Hirsiger, Sebastian Weigang, Antje-Christine Walz, Jonas Fuchs, Mary-Louise Daly, Stefan Eggimann, Oliver Hausmann, Martin Schwemmle, Georg Kochs , Marcus Panning, Klaus Warnatz, Mike Recher, Christoph T Berger
- Nat Microbiol. 2022 Apr 28.doi: 10.1038/s41564-022-01106-y
SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals
Julia Lang-Meli, Hendrik Luxenburger, Katharina Wild, Vivien Karl, Valerie Oberhardt, Elahe Salimi Alizei, Anne Graeser, Matthias Reinscheid, Natascha Roehlen, David B Reeg, Sebastian Giese, Kevin Ciminski, Veronika Götz, Dietrich August, Siegbert Rieg, Cornelius F Waller, Tobias Wengenmayer, Dawid Staudacher, Daniela Huzly, Bertram Bengsch, Georg Kochs, Martin Schwemmle, Florian Emmerich, Tobias Boettler, Robert Thimme, Maike Hofmann, Christoph Neumann-Haefelin
Nature Communications volume 13, Article number: 1152 (2022)
Antibody escape and global spread of SARS-CoV-2 lineage A.27
Tamara Kaleta, Lisa Kern, Samuel Leandro Hong, Martin Hölzer, Georg Kochs, Julius Beer, Daniel Schnepf, Martin Schwemmle, Nena Bollen, Philipp Kolb, Magdalena Huber, Svenja Ulferts, Sebastian Weigang, Gytis Dudas, Alice Wittig, Lena Jaki, Abdou Padane, Adamou Lagare, Mounerou Salou, Egon Anderson Ozer, Ndodo Nnaemeka, John Kofi Odoom, Robert Rutayisire, Alia Benkahla, Chantal Akoua-Koffi, Abdoul-SalamOuedraogo, Etienne Simon-Lorière, Vincent Enouf, Stefan Kröger, Sébastien Calvignac-Spencer, Guy Baele, Marcus Panning & Jonas Fuchs
EMBO Reports (2021)e53865
Biparatopic nanobodies protect mice from lethal challenge with SARS-CoV-2 variants of concern
Teresa R Wagner, Daniel Schnepf, Julius Beer, Natalia Ruetalo, Karin Klingel, Philipp D Kaiser, Daniel Junker, Martina Sauter, Bjoern Traenkle, Desiree I Frecot, Matthias Becker, Nicole Schneiderhan-Marra, Annette Ohnemus, Martin Schwemmle, Michael Schindler, Ulrich Rothbauer
Nat Commununications 2021 Nov 4;12(1):6405.doi: 10.1038/s41467-021-26602-3.
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants
Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Sci Transl Med. 2021 Nov 24;13(621):eabi7826.doi: 10.1126/scitranslmed.abi7826. Epub 2021 Nov 24.
An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models
Bert Schepens, Loes van Schie, Wim Nerinckx, Kenny Roose, Wander Van Breedam, Daria Fijalkowska, Simon Devos, Wannes Weyts, Sieglinde De Cae, Sandrine Vanmarcke, Chiara Lonigro, Hannah Eeckhaut, Dries Van Herpe, Jimmy Borloo, Ana Filipa Oliveira, João Paulo Portela Catani, Sarah Creytens, Dorien De Vlieger, Gitte Michielsen, Jackeline Cecilia Zavala Marchan, George D Moschonas, Iebe Rossey, Koen Sedeyn, Annelies Van Hecke, Xin Zhang, Lana Langendries, Sofie Jacobs, Sebastiaan Ter Horst, Laura Seldeslachts, Laurens Liesenborghs, Robbert Boudewijns, Hendrik Jan Thibaut, Kai Dallmeier, Greetje Vande Velde, Birgit Weynand, Julius Beer, Daniel Schnepf, Annette Ohnemus, Isabel Remory, Caroline S Foo, Rana Abdelnabi, Piet Maes, Suzanne J F Kaptein, Joana Rocha-Pereira, Dirk Jochmans, Leen Delang, Frank Peelman, Peter Staeheli, Martin Schwemmle, Nick Devoogdt, Dominique Tersago, Massimiliano Germani, James Heads, Alistair Henry, Andrew Popplewell, Mark Ellis, Kevin Brady, Alison Turner, Bruno Dombrecht, Catelijne Stortelers, Johan Neyts, Nico Callewaert, Xavier Saelens
Nature. 2021 Sep;597(7875):268-273.doi: 10.1038/s41586-021-03841-4. Epub 2021 Jul 28.
Rapid and stable mobilization of CD8 + T cells by SARS-CoV-2 mRNA vaccine
Valerie Oberhardt, Hendrik Luxenburger, Janine Kemming, Isabel Schulien, Kevin Ciminski, Sebastian Giese, Benedikt Csernalabics, Julia Lang-Meli, Iga Janowska, Julian Staniek, Katharina Wild, Kristi Basho, Mircea Stefan Marinescu, Jonas Fuchs, Fernando Topfstedt, Ales Janda, Oezlem Sogukpinar, Hanna Hilger, Katarina Stete, Florian Emmerich, Bertram Bengsch, Cornelius F Waller, Siegbert Rieg, Sagar, Tobias Boettler, Katharina Zoldan, Georg Kochs, Martin Schwemmle, Marta Rizzi, Robert Thimme, Christoph Neumann-Haefelin, Maike Hofmann
JAMA Pediatr. 2021 Jun 1;175(6):586-593.doi: 10.1001/jamapediatrics.2021.0001.
Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany
Burkhard Tönshoff, Barbara Müller, Roland Elling, Hanna Renk, Peter Meissner, Hartmut Hengel, Sven F Garbade, Meinhard Kieser, Kathrin Jeltsch, Jürgen Grulich-Henn, Julia Euler, Maximilian Stich, Kristine Chobanyan-Jürgens, Maria Zernickel, Aleš Janda, Lena Wölfle, Thomas Stamminger, Thomas Iftner, Tina Ganzenmueller, Christian Schmitt, Tessa Görne, Vibor Laketa, Sylvia Olberg, Anna Plaszczyca, Mirko Cortese, Ralf Bartenschlager, Constantin Pape, Roman Remme, Daniela Huzly, Marcus Panning, Sebastian Weigang, Sebastian Giese, Kevin Ciminski, Jakob Ankerhold, Georg Kochs, Martin Schwemmle, Rupert Handgretinger, Charlotte M Niemeyer, Corinna Engel, Winfried V Kern, Georg Friedrich Hoffmann, Axel R Franz, Philipp Henneke, Klaus-Michael Debatin, Hans-Georg Kräusslich
Nat Med. 2021 Jan;27(1):78-85.doi: 10.1038/s41591-020-01143-2. Epub 2020 Nov 12.
Characterization of pre-existing and induced SARS-CoV-2-specific CD8 + T cells
Isabel Schulien, Janine Kemming, Valerie Oberhardt, Katharina Wild, Lea M Seidel, Saskia Killmer, Sagar, Franziska Daul, Marilyn Salvat Lago, Annegrit Decker, Hendrik Luxenburger, Benedikt Binder, Dominik Bettinger, Oezlem Sogukpinar, Siegbert Rieg, Marcus Panning, Daniela Huzly, Martin Schwemmle, Georg Kochs, Cornelius F Waller, Alexandra Nieters, Daniel Duerschmied, Florian Emmerich, Henrik E Mei, Axel Ronald Schulz, Sian Llewellyn-Lacey, David A Price, Tobias Boettler, Bertram Bengsch, Robert Thimme, Maike Hofmann, Christoph Neumann-Haefelin
Head:
Prof. Dr. med. Hartmut Hengel
hartmut.hengel@uniklinik-freiburg.de
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