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Sabrina Schreiner & Team


Research focus

Our lab focuses on a detailed understanding of adenoviral replication strategies and manipulation of the host cell nuclear processes as a basis to further develop novel antiviral intervention therapies.
 
Human adenoviruses cause conjunctivitis, gastrointestinal illnesses and pneumonia, among other things. In most cases however an infection exhibits no symptoms or only mild symptoms in healthy adults. However, for individuals with immune system deficiencies the course of the infection can have serious effects or even be fatal. An infection is particularly dangerous for children following a stem cell transplant. In this case, we need to block virus replication and lower the mortality rate for infected patients.
 
We are investigating how the virus reproduces in the cell with a special focus on marked changes in what are called PML nuclear complexes made up of several proteins within the cell. These structures, which are round in the uninfected cell, dissolve after adenovirus infection and form elongated fibrils. This pathogenic process will be modulated and blocked to hinder the virus making use of this cellular manipulation for their own reproduction and benefit. Same strategies will be also validated for other human pathogenic viruses to develop broad spectrum intervention therapies.


Funding

Head and Team Leader

Prof. Dr. Sabrina Schreiner

Phone: +49 761 270 83342

PostDoc

Dr. Julia Mai

Phone: +49 761 270 83343

PostDoc

Dr. Sawinee Masser

Phone: +49 761 270 83343

PostDoc

Dr. Shahinda Rezk

Phone: +49 761 270 83343

PhD student

Eslam Sadeldin

Phone: +49 761 270 83343

MD Student

Julian Kurz

Phone: +49 761 270 83343

MD Student

Elisabeth Heigold

Phone: +49 761 270 83343

Technician

Annette Ohnemus

Phone: +49 761 270 83446


Head:
Prof. Dr. med. Hartmut Hengel
hartmut.hengel@uniklinik-freiburg.de

SecretaryAdministrationInformation desk

Kristina Gendrisch

Telefon: 0761 270-83480

Telefax: 0761 203-6626

Email: kristina.gendrisch@uniklinik-freiburg.de

Gudrun Simpson

Telefon: 0761 270-83711

Telefax: 0761 203-6562

Email: gudrun.simpson@uniklinik-freiburg.de

Jutta Schneeberger

Telefon: 0761 270-83700

Telefax: 0761 203-6562

Email: jutta.schneeberger@uniklinik-freiburg.de