Publikationen
- Heiland DH, Haaker G, Watzlawick R, Delev D, Masalha W, Franco P, Machein M, Staszewski O, Oelhke O, Nicolay NH, Schnell O. Correction to: One decade of glioblastoma multiforme surgery in 342 elderly patients: what have we learned? J Neurooncol. 2018 Nov;140(2):393. Epub
- Heiland DH, Haaker G, Watzlawick R, Delev D, Masalha W, Franco P, Machein M, Staszewski O, Oelhke O, Nicolay NH, Schnell O. One decade of glioblastoma multiforme surgery in 342 elderly patients: what have we learned? J Neurooncol. 2018 Nov;140(2):385-391. Epub
- Baumgarten P, Blank AE, Franz K, Hattingen E, Dunst M, Zeiner P, Hoffmann K, Bähr O, Mäder L, Goeppert B, Machein M, Seifert V, Steinbach JP, Plate KH, Harter PN, Mittelbronn M: Differential expression of vascular endothelial growth factor A, its receptors VEGFR-1, -2, and -3 and co-receptors neuropilin-1 and -2 does not predict bevacizumab response in human astrocytomas. Neuro-oncology, 2016; 18 (2): 173-183. Epub
- Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR: Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro-oncology, 2016; 18 (7): 939-949. Epub
- Heiland DH, Masalha W, Franco P, Machein MR, Weyerbrock A. Progression-free and overall survival in patients with recurrent Glioblastoma multiforme treated with last-line bevacizumab versus bevacizumab/lomustine. J Neuro-oncol, 2016; 126 (3): 567-575. Epub
- Roelz R, Reinacher P, Jabbarli R, Kraeutle R, Hippchen B, Egger K, Weyerbrock A, Machein M: Surgical Ventricular Entry is a Key Risk Factor for Leptomeningeal Metastasis of High Grade Gliomas. Sci Rep-uk, 2015; 5 (online): 17758. Epub
- Prasad S, Gaedicke S, Machein M, Mittler G, Braun F, Hettich M, Firat E, Klingner K, Schueler J, Wider D, Wäsch RM, Herold-Mende C, Elsässer-Beile U, Niedermann G. Effective eradication of glioblastoma stem cells by local application of an AC133/CD133-specific T cell-engaging antibody and CD8 T cells. Cancer Res. 2015;75(11):2166-76. Epub.
- Schneider K, Weyerbrock A, Doostkam S, Plate K, Machein MR. Lack of evidence for PlGF mediating the tumor resistance after anti-angiogenic therapy in malignant gliomas. J Neuro-oncol, 2015; 121 (2): 269-278. Epub
- Machein MR, Plate KH. Bone marrow chimera experiments to determine the contribution of hematopoietic stem cells to cerebral angiogenesis. Methods Mol Biol. 2014;1135:275-88. Epub .
- Gaedicke S, Braun F, Prasad S, Machein M, Firat E, Hettich M, Gudihal R, Zhu X, Klingner K, Schüler J, Herold-Mende CC, Grosu AL, Behe M, Weber W, Mäcke H, Niedermann G. Noninvasive positron emission tomography and fluorescence imaging of CD133+ tumor stem cells. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6): E692-701. Epub.
- Reithmeier T, Lopez WO, Doostkam S, Machein MR, Pinsker MO, Trippel M, Nikkhah G. Intraindividual comparison of histopathological diagnosis obtained by stereotactic serial biopsy to open surgical resection specimen in patients with intracranial tumours. Clin Neurol Neurosurg. 2013 Oct;115(10):1955-60. Epub.
- Beck H, Raab S, Copanaki E, Heil M, Scholz A, Shibuya M, Deller T, Machein M, Plate KH. VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke model. J Neuropathol Exp Neurol. 2010 Feb;69(2):168-75. Epub.
- Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR. Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer. 2009 Oct 15; 125(8):1771-7. PDF-Datei 10
- Machein M, de Miguel LS. Angiogenesis in gliomas. Recent Results Cancer Res. 2009; 171:193-215. Review.
- Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, Tchaikovski V, Waltenberger J, Shibuya M, Plate KH, Machein MR. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res. 2008 Sep 15; 68(18):7342-51. PDF-Datei 9
- Reiss Y, Machein MR, Plate KH. The role of angiopoietins during angiogenesis in gliomas. Brain Pathol. 2005 Oct;15(4):311-7. Review.
- Machein MR, Knoth R, Plate KH. Endothelial cell transplantation for gene therapy in experimental gliomas. Neurosurgery. 2005 Dec;57(6):1264-71; discussion 1264-71.
- Machein MR, Knedla A, Knoth R, Wagner S, Neuschl E, Plate KH. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am J Pathol. 2004 Nov;165(5):1557-70. PDF-Datei 1
- Heidenreich R, Machein M, Nicolaus A, Hilbig A, Wild C, Clauss M, Plate KH, Breier G. Inhibition of solid tumor growth by gene transfer of VEGF receptor-1 mutants. Int J Cancer. 2004 Sep 1;111(3):348-57. PDF-Datei 8
- Machein MR, Plate KH. Role of VEGF in developmental angiogenesis and in tumor angiogenesis in the brain. Cancer Treat Res. 2004;117:191-218. Review. No abstract available.
- Dwenger A, Rosenthal F, Machein M, Waller C, Spyridonidis A. Transplanted bone marrow cells preferentially home to the vessels of in situgenerated murine tumors rather than of normal organs. Stem Cells. 2004;22(1):86-92. PDF-Datei 5
- Machein MR, Renninger S, de Lima-Hahn E, Plate KH. Minor contribution of bone marrow-derived endothelial progenitors to the vascularization of murine gliomas. Brain Pathol. 2003 Oct;13(4):582-97. PDF Datei 4
- Machein MR, Plate KH. VEGF in brain tumors. J Neurooncol. 2000 Oct-Nov;50(1-2):109-20. Review.VEGF in brain tumors. J Neurooncol. 2000 Oct-Nov;50(1-2):109-20. Review.
- Donnini S, Machein MR, Plate KH, Weich HA. Expression and localization of placenta growth factorand PlGF receptors inhuman meningiomas. J Pathol. 1999 Sep;189(1):66-71. human meningiomas.J Pathol. 1999 Sep;189(1):66-71. PDF Datei 6
- Machein MR, Risau W, Plate KH. Antiangiogenic gene therapy in a rat glioma model using a dominant-negative vascular endothelial growth factor receptor 2. Hum Gene Ther. 1999 May 1;10(7):1117-28. PDF Datei 2
- Machein MR, Kullmer J, Ronicke V, Machein U, Krieg M, Damert A, Breier G,Risau W, Plate KH. Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells. Neuropathol Appl Neurobiol. 1999 Apr;25(2):104-12. PDF Datei 7
- Machein MR, Kullmer J, Fiebich BL, Plate KH, Warnke PC. Vascular endothelial growth factor expression, vascular volume, and, capillarypermeability in human brain tumors.Neurosurgery. 1999 Apr;44(4):732-40; discussion 740-1.
- Lampert K, Machein U, Machein MR, Conca W, Peter HH, Volk B. Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.Am J Pathol. 1998 Aug;153(2):429-37. PDF Datei 3
- Damert A, Machein M, Breier G, Fujita MQ, Hanahan D, Risau W, Plate KH. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.Cancer Res. 1997 Sep 1;57(17):3860-4.
- Stratmann A, Machein MR, Plate KH. Anti-angiogenic gene therapy of malignant glioma. Acta Neurochir Suppl. 1997;68:105-10. Review.
AG-Leitung
Prof. Dr. Marcia Machein
AG-Leitung, Oberärztin