Dr. Vidhya Madapusi (M.) Ravi
Personal Data
| Title | Dr |
| First name | Vidhya |
| Name | Madapusi Ravi |
| Current position | Principal Investigator |
Current institution(s)/site(s), country Department | University Hospital Freiburg, Germany Neurosurgery |
| Identifiers/ORCID | 0000-0003-0062-2099
|
Professional Summary
Dynamic and accomplished research leader with expertise in developing advanced 3D brain models for neurodegenerative diseases. Proven success in securing high-impact funding, leading interdisciplinary teams, and translating research into clinical applications. Committed to bridging academia and industry through innovation, collaboration, and leadership in neuro-oncology and computational neurobiology.
| | Periods and Details |
| Stages of academic/professional Career | Feb 2023-Present: Principal Investigator: “3D-Brain Models (3D-BM) for Neurodegenerative Diseases, Department of Neurosurgery, University Clinic of Freiburg. 3D-Brain Models Lab | Universitätsklinikum Freiburg (uniklinik-freiburg.de) From Oct 2024- Appointed as a Biological Safety Officer for S1 and S2 Facilities in University Clinic Freiburg. Sep 2018 - Feb 2023: Junior PI at Department of Neurosurgery, University Clinic of Freiburg. Oct 2021- July 2022: Freiburg Institute of Advanced Studies (FRIAS) Junior Fellow. Apr 2017 – Sep 2018: Post-doctoral research scientist at “Sections for Neuroelectronic Systems; University Clinic of Freiburg. June 2016-Dec 2016: Post-doctoral Research Scientist at “FMP- Leibniz Institute Berlin” |
| Doctorate | Oct 2012- Mar 2016: Ph.D., Department of Biophysics and Biochemistry, University Autonoma de Barcelona, Spain https://www.tdx.cat/handle/10803/370110 (Grade: Exceptional Cum Laude with Honors) |
| Degree programme | 2007- 2009: Master’s in Bioinformatics, Chennai, India (Grade: 1.0) 2004- 2007: Bachelor’s in Chemistry, Chennai, India. (Grade: 1.0) |
Activities in the Research System
2022-Present: Founder and Chief Organizer for International conference “Vis à vis in the Brain: The Neuron-Glia Interface” in Freiburg (Sep 9th-11th 2022) & (Sep 13th-15th 2023) (https://www.uniklinik-freiburg.de/ngi-freiburg.html#c219979)
2020- Present: Reviewer for multiple internationally renowned journals, such as Journal of Neuroinflammation, Neuro-oncology, BMC Cancer, Cellular and Molecular Neurobiology and Journal of Neuro-oncology; Editorial role for Frontiers in Oncology and Frontiers in Immunology.
Invited Talks:
Nov 2024- “Ex-vivo Human Brain Models” Karlsruhe Institute of Technology
Apr 2024- Invited talk in Scandinavian society for neuro-oncology (SNOG) organized by Dr. Rautajoki https://cancerakademin.se/event/snog-symposium-2024-multidisciplinary-neuro-oncology-meeting/?lang=en
Nov 2023: Cancer Neuroscience Lecture Series hosted by Prof. Shawn Hervey Jumper, Department of Neurosurgery UCSF: “Studying Beast in its Ecosystem: Human Organotypic Glioblastoma Model” (https://x.com/HerveyJumper/status/1730247339997376993)
Sep 2023: VNA international webinar- 3D-Cell Culture 2023 Conference- Human Organotypic brain slice culture.
Dec 2022: Frontline Genomics webinar: “Spatial Heterogeneity in Glioblastoma”
May 2022: SNOG-Helsinki, Finland “The Role of Aging in Glioblastoma”
Dec 2021: EMBL webinar: “Spatially Resolved multi-omics deciphers bidirectional tumor-host interdependence in Glioblastoma”.
Academic Distinctions
2023: Advancement award for Neuro-Oncology 2023, Stiftung Sibylee Assmus.
2022: EANO Youngster Award 2022 for Outstanding publication in the field of NeuroOncology.
2021: Junior Freiburg Institute of Advanced Studies (FRIAS) Fellow, Freiburg, Germany
2012-2016: FI-DGR AGAUR grant 50.000€ for 3 Years and FI-DGR AGAUR Thesis prize award of 3000 € provided for outstanding doctoral candidates in Barcelona, Spain.
Awarded Grants
Nov 2024 – Nov 2026 : Baden-Württemberg Stiftung for Alternative animal models “Untersuchung der Interaktion zwischen Meningeomen und Gliazellen anhand humaner Meningeommodelle „ (100.000€)
Jun 2024- Apr 2025 (Industrial Collaboration): Research Fund from the pharmaceutical company to understand the “Troipsm of AAV-9 vectors in the human brain microenvironment” (250.000 €)
Apr 2024- Oct 2024: Internal Research Funding from University Hospital Freiburg to “Explore the microenvironment of Meningioma using 3D Brain Models” (25.000 €)
Oct 2023- Nov 2024: Advancement award for Neuro-Oncology 2023, Stiftung Sibylee Assmus. (20.000 €)
July 2023- Aug 2025: DFG-Research Grant “Der Onkometabolit D-2-Hydroxy-Glutarat verursacht reaktive Astrogliose in der Mikroumgebung von IDH-mutierten Gliomen“ https://gepris.dfg.de/gepris/projekt/521419277 (250.275 €)
Jan 2023-Feb 2028 (Collaboration): AIRC grant in collaboration with Dr. Eleonora Vannini (500.000 €)
Oct 2021-July 2022: Fellowship from Freiburg Institute of Advanced Studies (FRIAS), Freiburg, Germany (20.000 € for 1 year)
Full Publication List: (2016-Present)
*IF- Impact factor
| Impact Factor |
| Wang L.Y, Ravi. V.M et al., “Helical unwinding and side chain unlocking unravel the outward open conformation of the melibiose transporter”. Scientifics Reports (2016) | 3.8 |
Heiland D.H* & Ravi. V.M.* et al. “Tumor Associated Astrocytes aid the evolution of immunosuppressive environment in Glioblastoma. Nature Communications (2019)
| 17.69 |
| Ravi. V.M, Joseph K…Heiland D.H. „ Human Organotypic Brain Slice culture: a novel framework for environmental research in neuro-oncology. Life Science Alliance (2019) | 5.2 |
| Wurum J, Behringer SP, Ravi V.M. et al., „ Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma”. Cancers (2019) | 6.5
|
| M. Schneider, L. Vollmer, A-L. Pothoff, Ravi. V.M…et al., Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. Neuro-oncology (2021) | 15.9 |
| d’Errico P, Ziegler-Waldkirch… Ravi. V.M et al., Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nature Neuroscience (2021) | 28.7 |
| Maier JP*, Ravi V.M* et al., Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell death and Disease (2021) | 12.07
|
| Ravi. V.M, ...... et al., T-cell dysfunction in Glioblastoma Microenvironment in mediated by myeloid cells releasing Interleukin-10. Nature communications (2022) | 17.6 |
| Ravi. V.M…et al., Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell (2022) | 50.3 |
| Buehler M, Yi.X, Ge. W, … Ravi V.M. et al., „Quantitative proteomic landscape of primary and recurrent glioblastoma reveals a protumorigenic role for FBXO2 dependent glioma microenvironment interactions”. Neuroncology (2022) | 13.0 |
| Meister H, Look T, Roth P.... Ravi V.M. et al., “Multifunctional mRNA-based CART cells display promising Antitumor activity against Glioblastoma”. (Clinical Cancer Research) (2022) | 13.8 |
| Guyon J, Fernandez-Moncada, LArrieu, CM…Ravi. V.M et al., “Lactate dehydrogenase promote glioblastoma growth and invasion via a metabolic symbiosis”. EMBO Molecular Medicine) (2022) | 14.0 |
| Grote A, Heiland DH… Ravi V.M et al., “Hippocampal innate inflamtory gliosis only in pharmacoresistant temporal lobe epilepsy”. (2023) | 15.26 |
| Kuliesiute U, Joseph K, Ravi. V.M et al., Sialic acid metabolism orchestrates transcellular connectivity and signaling in glioblastoma. Neuro-Oncology (2023) | 15.91 |
| Zhang J, Straehle J, Joseph K,… Ravi V.M, Isolation and profiling of viable tumor cells from human ex vivo glioblastoma cultures through single-cell transcriptomics. Star Protocols (2023) | 1.56 |
| Straehle J, Ravi V.M.. et al., Technical report: surgical preparation of human brain tissue for clinical and basic research. Acta Neurochirurgica (2023) | 2.4 |
| Benotmane JK, Kueckelhaus J, Ravi.V.M… Henrik D. H. High-sensitive spatially resolved T- Cell receptor sequencing with SPTCR-seq. Nat Com (2023) | 17.9 |
| Ritter M , Blume C ….Ravi V. M,…. Heiland D. H, Sahm Spatially resolved transcriptomics and graph-based deep-learning improve accuracy of routine CNS tumor diagnostics (Nat Cancer) 2024. | 23.5 |
Thievand CP, Oceane Anezo1, Aafrin M. Pettiwala, Guillaume Bourmeau…. Ravi V.M, Joseph K… Seano G “Vessel co-option and glioblastoma resistance to therapy is induced by a transition to a senescent and slow-cycling cell state Nat Com (2024)
| 17.6 |
| Snacel-Fazy E, Soubéran A, Grange M, Joseph K, Colin C, Morando P, Luche H, Pagano A, Brustlein S, Debarbieux F, ….. Ravi V.M, Emeline Tabouret, Aurélie Tchoghandjian. SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment | 23.5 |
| Sojka C , Wang H , Li Y , Chopra P , Sing A , Voss A ,King A , Wang F , Kevin Joseph , Ravi V.M , …..Stevel Sloan Divergence from Human Astrocytes developmental trajectory in Gliolbastoma (Nat. Cell Biology) | 26.5 |
| Bourmeau G,Anezo O, Raymond J, Ballestín A…….Ravi V.M, Joseph K, Giorgio Seano. Proneural-Mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import (Neurooncology) | 16.4 |
| Ferrarese R, Joseph K, Andrieux G….Ravi V. M , Melanie Boerries2,3,7 6 , Dieter Henrik Heiland1,7, and Maria Stella Carro1*ZBTB18 regulates cytokine expression and affects microglia/macrophage recruitment and commitment in glioblastoma (Cell Dieath and Disease) | 8.5 |
| Total Impact Factor | 367.59 |
| Total Citations | 1421 |
| h-Index | 14 |
| i-10 Index | 15 |
Klinik für Neurochirurgie
im Neurozentrum
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