Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Clinician-Scientists

Clinician-Scientists

Julia Stomper, MD (2017 – 2020)

Tina Jöckel, MD (2010 – 2012)

Jesús Duque-Afonso, MD (2010 – 2012)

Barbara Deschler, MD (2003 – 2011)

Nina Chevalier, MD (2008 – 2011)

Heiko Becker, MD (2005 – 2008)

Tobias Berg, MD (2002 – 2008)

Peter Haas, MD (2001 – 2008)

Björn Rüter, MD (2001 – 2007)

Rainer Claus, MD (1999 – 2006)

Björn Hackanson, MD (2003 – 2005)

Claudia Müller-Schmah, MD (2001 – 2004)

Michael Daskalakis, MD (1998 – 2001)

Jens Würthner, MD (1996 – 1998)

Daniel Jonas, MD (1989 – 1991)

Postdocs

Gabriele Greve, PhD (2017 – 2021)

John Rotondo, PhD (2017 – 2018)

Nadja Blagitko-Dorfs, PhD (2007 – 2016)

Margit Sauer, PhD (2012 – 2014)

Roland  Weis, MD (2007 – 2011)

Manfred Fliegauf, PhD (2008 – 2010)

Bernhard Kleine, PhD (2006 – 2008)

Statistician

Ljudmila Bogatyreva (2007 – 2017)

PhD students

Tzu-Ting Wei (2018 – 2019)

Zoe Sawitzki (2016 – 2018)

Gabriele Greve (2010 – 2017)

Pascal Schlosser (2012 – 2016)

Gregor Klaus (2011 – 2015)

Yi Jiang (2005 – 2007)

Manfred Fliegauf (1996 – 2002)

Medical doctoral students

Kevin Moschallski ( 2020 - 2023)

Ruth Meier (2016 - 2022)

Kai Rejeski (2015 – 2019)

Insa Schiffmann (2013 – 2017)

Aitomi Essig (2010 – 2012)

Jan Kay Hiller (2008 – 2011)

David Leander Rimmele (2008 – 2010)

Maria Leticia Solari (2007 – 2011)

Jesús Duque-Afonso (2004 – 2010)

Maika Almstedt (2004 – 2009)

Lena Kasten (2004 - 2007)

Yalin Guo (2001 – 2004)

Rainer Claus (1999 – 2004)

Carsten Kobe (1998 – 2000)

Anna Peuckert (1998 – 2000)

Claudia Pötzsch (1995 – 1997)

Arndt Schottelius (1991 – 1994)

Thesis students

Jamie Butler (2024)

Annika Heck, B.Sc. (2020)

Anne Rubarth, M.Sc. (2018 – 2020)

Kay Chmielewski, M.Sc. (2017 – 2018)

Akinnurun Oluwafemi, B.Sc. (2015)

Thomas Benkler (2009)

Sara Cohen (2008 – 2009)

Maike Buchner, M.Sc. (2005 – 2006)

Josephus Kim (2005-2006)

Technicians

Lea Gutenkunst (2018 - 2021)

Ruhtraut Ziegler (2014 – 2021)

Frederik Henes (2018 – 2021)

Carmen Strittmatter (2014 – 2016)

Angela Koch (1994 – 2010)

Brigitte Joos (2007 – 2008)

Melanie Feuerstein (2005 – 2006)

Mahmoud Abdelkarim (2001 – 2005)

Johanna Römmelt (1991 – 1996)

Regina Ruszcinsky (1990 – 1992)

Research Assistants

Pilar Casais Onaindia (2024)

Elizaveta Bubnova (2021 – 2023)

Dennis Zimmer (2019 - 2021)

Bettina Berberich (2018 - 2021)

Dana Eble, B. Sc. (2018)

Sina Bengel, M.Sc. (2016 – 2018)

Philipp N. Sander, M.Sc. (2014 – 2018)

Tina Röder, M.Sc. (2016 – 2018)

Juliane Steinmann (2012 – 2016)

Katharina Düker, M.Sc. (2014 – 2016)

Sandra Nitsch, M.Sc. (2014 – 2015)

Julian Eble, M.Sc. (2014 – 2015)

Monique Braun (2008 – 2011)

Maren Prinz (2008 – 2010)

Tobias Berg (2002 – 2005)

Peter Haas (2002 – 2006)

May, 2023

DFG research group meeting; 30. April 2023 - 3. Mai 2023 in Cadenabbia, Italien / Italy

May, 2021

Review published

Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.
Stomper J, Rotondo JC, Greve G, Lübbert M. Leukemia. 2021 May 6. doi: 10.1038/s41375-021-01218-0. Online ahead of print. PMID: 33958699

May, 2021

Second funding period for DFG FOR2674 grant accepted

Titel: Alters-assoziierte epigenetische Veränderungen als therapeutischer Ansatzpunkt in der Behandlung der akuten myeloischen Leukämie,
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 336840530

April, 2021

Original Article published

Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients.
Stomper J, Meier R, Ma T, Pfeifer D, Ihorst G, Blagitko-Dorfs N, Greve G, Zimmer D, Platzbecker U, Hagemeijer A, Schmitt-Graeff I, Lübbert M.
Clin Epigenetics. 2021 Apr 12;13(1):77.
doi: 10.1186/s13148-021-01052-2. PMID: 33845873

DECIDER-1

„Prospective Randomized Multicenter Phase II Trial of Low-dose Decitabine (DAC) Administered Alone or in Combination With the Histone Deacetylase Inhibitor Valproic Acid (VPA) and All-trans Retinoic Acid (ATRA) in Patients > 60 Years With Acute Myeloid Leukemia Who Are Ineligible for Induction Chemotherapy“
(NCT00867672, AMLSG 14-09)

Phase II, recruitment period: 2011 – 2016

204 recruited participants

EORTC AML21 („inDACtion vs. induction“)

„10-day Decitabine Versus Conventional Chemotherapy ("3+7") Followed by Allografting in AML Patients ≥ 60 Years: a Randomized Phase III Study of the EORTC Leukemia Group, CELG, GIMEMA and German MDS Study Group (NCT02172872, EORTC 1301)

Phase III, recruitment period: 2015 – 2019

606 recruited participants

TRANSATRA

„Phase I/II Study of Sensitization of Non-M3 Acute Myeloid Leukemia (AML) Blasts to All-trans Retinoic Acid (ATRA) by Epigenetic Treatment With Tranylcypromine (TCP), an Inhibitor of the Histone Lysine Demethylase 1 (LSD1)“ (NCT02717884)

Phase I/II, recruitment period: 2015 – 2020

25 recruited participants

EORTC 06011

„Intravenous Low-Dose Decitabine Versus Supportive Care in Elderly Patients With Primary Myelodysplastic Syndrome (MDS) (>10% Blasts or High-Risk Cytogenetics), Secondary MDS or Chronic Myelomonocytic Leukemia (CMML) Who Are Not Eligible for Intensive Therapy:
An EORTC-German MDS Study Group Randomized Phase III Study“ (NCT00043134)

Phase III, recruitment period: 2003 – 2007

233 recruited participants

FR00331

„A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy“
(DRKS00000069)

Phase II, recruitment period: 2003 – 2007

227 recruited participants

DECIDER-2

„Prospective randomized multicenter phase III trial of decitabine and Venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy“ (AMLSG 32-21)

Phase III, to be initiated, recruitment start projected for QIV 2021, planned: 250 participants

Phase III, activated October 2022

planned: 250 participants recruited from > 30 clinical centers throughout Germany, study is currently recruiting

• Maya André, MD PhD, Tübingen
• Geoffroy Andrieux, PhD, Freiburg
• Heiko Becker, MD, Freiburg
• Markus Bender, PhD, Würzburg
• Tobias Berg, MD, Hamilton, Canada
• Melanie Börries, MD PhD, Freiburg
• Steffen Böttcher, MD, Zürich
• Benedikt Brors, PhD, DKFZ Heidelberg
• Gesine Bug, MD, Frankfurt
• Nina Cabezas-Wallscheid, PhD, MPI-IE Freiburg
• Michael Cleary, MD, Stanford University, CA
• Sven Diederichs, PhD, Freiburg
• Hartmut Döhner, MD, Ulm
• Konstanze Döhner, MD, Ulm
• Jesús Duque-Afonso, MD, Freiburg
• Jürgen Finke, MD, Freiburg
• Christian Flotho, MD, Freiburg
• Arnold Ganser, MD, Hannover
• Ulrich Germing, MD, Düsseldorf
• Elizabeth Griffiths, MD, Buffalo, NY
• Björn Hackanson, MD, Augsburg
• Anne Hagemeijer, PhD, Leuven, Belgium
• Michael Heuser, MD, Hannover
• Gerwin Huls, MD, Groningen, The Netherlands
• Gabriele Ihorst, PhD, ZKS Freiburg
• Joop Jansen, PhD, Nijmegen, The Netherlands
• Thomas Jenuwein, PhD, MPI-IE Freiburg
• Peter A. Jones, PhD, VAI, Grand Rapids, MI
• Manfred Jung, PhD, Freiburg
• Michal Kicinski, PhD, EORTC, Brussels, Belgium
• Mark Kirschbaum, MD, New York, NY
• Raphael Koch, MD, Göttingen
• Phillip Koeffler, MD, Los Angeles, CA
• Daniel Lipka, MD, DKFZ Heidelberg
• Philipp Mallm, PhD, DKFZ Heidelberg
• Richard Momparler, PhD, Montréal, Canada
• Andreas Neubauer, MD, Marburg
• Seishi Ogawa, MD, Kyoto, Japan
• Dietmar Pfeifer, PhD, Freiburg
• Christoph Plass, PhD, DKFZ Heidelberg
• Uwe Platzbecker, MD, Leipzig
• Hugh Y. Rienhoff, MD, San Francisco, CA
• Karsten Rippe, PhD, DKFZ Heidelberg
• Michael Schmitt, MD, Heidelberg
• Annette Schmitt-Gräff, MD, Freiburg
• Claudia Schmoor, PhD, ZKS Freiburg
• Roland Schüle, PhD, Freiburg
• Jan Stratmann, MD, Frankfurt
• Stefan Suciu, PhD, EORTC, Brussels, Belgium
• Felicitas Thol, MD, Hannover
• Adriano Venditti, Rome
• Pierre W. Wijermans, MD PhD, The Hague, The Netherlands
• Robert Zeiser, MD, Freiburg

Selected preclinical and translational publications (2012 – 2024)

1. Klaus Geissler, Zdenek Koristek, Teresa Bernal Del Castillo, Jan Novák, Gabriela Rodríguez-Macías, Stephan K Metzelder, Arpad Illes, Jiří Mayer, Montserrat Arnan, Mary-Margaret Keating Jürgen Krauter, Monia Lunghi, Nicola Stefano Fracchiolla, Uwe Platzbecker, Valeria Santini, Yuri Sano, Aram Oganesian, Harold Keer, Michael Lübbert. Oral decitabine/cedazuridine versus intravenous decitabine for acute myeloid leukaemia: A randomised, crossover, registration, pharmacokinetics study. 
   Br J Haematol. 2024 Nov;205(5):1734-1745. PMID: 39313917 doi: 10.1111/bjh.19741. 

2. Bresser H, Schmoor C, Grishina O, Pfeifer D, Thomas J, Rehman UU, Crysandt M, Jost E, Thol F, Heuser M, Götze KS, Schlenk RF, Salih HR, Schittenhelm MM, Heil G, Schwaenen C, Müller-Tidow C, Brugger W, Kündgen A, de Wit M, Giagounidis A, Scholl S, Neubauer A, Krauter J, Bug G, May AM, Wäsch R, Duyster J, Döhner K, Ganser A, Döhner H, Hackanson B, Becker H, Lübbert M. Impact of TP53 Mutation Status in Elderly AML Patients When Adding All-Trans Retinoic Acid or Valproic Acid to Decitabine. 
   Eur J Haematol. 2024 Oct 13. doi: 10.1111/ejh.14304. Online ahead of print. PMID: 39400388

3. Thomas J, Rehman UU, Bresser H, Grishina O, Pfeifer D, Sollier E, Döhner K, Plass C, Becker H, Schmoor C, de Wit M, Lübbert M. Continued decitabine/all-trans retinoic acid treatment: extended complete remission in an elderly AML patient with multi-hit TP53 lesions and complex-monosomal karyotype. Clin Epigenetics. 2024 Sep 11;16(1):126. doi: 10.1186/s13148-024-01737-4. PMID: 39261919

4. Gentile G, Poggio T, Catalano A, Voutilainen M, Lahnalampi M, Andrade-Martinez M, Ma T, Sankowski R, Goncharenko L, Tholen S, Han K, Morgens DW, Prinz M, Lübbert M, Engel S, Hartmann TN, Cario G, Schrappe M, Lenk L, Stanulla M, Duyster J, Bronsert P, Bassik MC, Cleary ML, Schilling O, Heinäniemi M, Duque-Afonso J. Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL. Blood Adv. 2024 Jun 11;8(11):2846-2860.
   doi: 10.1182/bloodadvances.2023011582. PMID: 38598725; PMCID: PMC11176965.

5. Pelos G, Riester M, Pal J, Myacheva K, Moneke I, Rotondo JC, Lübbert M, Diederichs S. Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment.  Int J Cancer, 2023 Nov 10, PMID: 37947765

6. Goyal A, Bauer J, Hey J, Papageorgiou DN, Stepanova E, Daskalakis M, Scheid J, Dubbelaar M, Klimovich B, Schwarz D, Märklin M, Roerden M, Lin YY, Ma T, Mücke O, Rammensee HG, Lübbert M, Loayza-Puch F, Krijgsveld J, Walz JS, Plass C. DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts. Nat Commun., 2023 Oct 23;14(1):6731, PMID: 37872136

7. Schuster LC, Syed AP, Tirier SM, Steiger S, Seufert I, Becker H, Duque-Afonso J, Ma T, Ogawa S, Mallm JP, Lübbert M, Rippe K. Progenitor like cell type of an MLL-EDC4 fusion in acute myeloid leukemia. Blood Adv., 2023 Oct 11, PMID: 37820244

8. Mostufi-Zadeh-Haghighi G, Veratti P, Zodel K, Greve G, Waterhouse M, Zeiser R, Cleary ML, Lübbert M, Duque-Afonso J. Functional Characterization of Transforming Growth Factor-β Signaling in Dasatinib Resistance and Pre-BCR+ Acute Lymphoblastic Leukemia. Cancers (Basel), 2023 Aug 30;15(17):432, PMID: 37686604

9. Greve G, Andrieux G, Schlosser P, Blagitko-Dorfs N, Rehman U, Ma T, Pfeifer D, Heil G, Neubauer A, Krauter J, Heuser M, Salih H, Döhner K, Döhner H, Hackanson B, Boerries M, Lübbert M. In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts. Leukemia, 2023 May;37(5):1018-1027, PMID: 37024521

10. Blum S, Tsilimidos G, Bresser H, Lübbert M. Role of Bcl-2 inhibition in myelodysplastic syndromes.
    Int J Cancer. 15;152(8):1526-1535, 2023

11. Baumann J, Spindler M, Throm Y, Lübbert M, Bender M. Absence of early platelet increment in healthy mice during decitabine treatment.
    Sci Rep. 12(1):22266, 2022

12. Meier R, Greve G, Zimmer D, Bresser H, Berberich B, Langova R, Stomper J, Rubarth A, Feuerbach L, Lipka DB, Hey J, Grüning B, Brors B, Duyster J, Plass C, Becker H, Lübbert M. The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation. Blood Cancer J. 12(8):122, 2022

13. Rejeski K, Duque-Afonso J, Lübbert M. AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms. Oncogene. 40(38):5665-5676, 2021

14. Stomper J, Meier R, Ma T, Pfeifer D, Ihorst G, Blagitko-Dorfs N, Greve G, Zimmer D, Platzbecker U, Hagemeijer A, Schmitt-Graeff A, Lübbert L. Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients.
    Clin. Epigenetics 2021
     
15. Greve G, Schüler J, Grüning BA, Berberich B, Stomper J, Zimmer D, Gutenkunst L, Bönisch U, Meier R, Blagitko-Dorfs N, Grishina O, Pfeifer D, Weichenhan D., Plass C, Lübbert M (2020) Decitabine induces gene derepression on monosomic chromosomes: in vitro and in vivo effects in adverse-risk cytogenetics AML. Cancer Res.  DOI: 10.1158/0008-5472.CAN-20-1430 Published February 2021
     
16. Stomper J, Rotondo JC, Greve G, Lübbert M. Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.
    Leukemia. 35(7):1873-1889, 2021
     
17. Niemöller C, Wehrle J, Riba J, Claus R, Renz N, Rhein J, Bleul S, Stosch JM, Duyster J, Plass C, Lutsik P, Lipka DB,  Lübbert M, Becker H.
    Bisulfite-free epigenomics and genomics of single cells analyzed by methylation sensitive restriction (epi-gSCAR). Comm. Biol. 2021
     
18. Schlosser P, Knaus J, Schmutz M, Dohner K, Plass C, Bullinger L, Claus R, Binder H, Lübbert M, Schumacher M. Netboost: Boosting-supported Network Analysis Improves High-Dimensional Omics Prediction in Acute Myeloid Leukemia and Huntington's Disease.
    IEEE/ACM Trans Comput Biol Bioinform. May 1, 2020. PP
     
19. Becker H, Pfeifer D, Ihorst G, Pantic M, Wehrle J, Rüter BH, Bullinger L, Hackanson B, Germing U, Kuendgen A, Platzbecker U, Döhner K, Ganser A, Hagemeijer A, Wijermans PW, Döhner H, Duyster J, Lübbert M. Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia. Ann Hematol. 99:1551-1560, 2020
     
20. Becker H, Greve G, Kataoka K, Mallm JP, Duque-Afonso J, Ma T, Niemöller C, Pantic M, Duyster J, Cleary ML, Schüler J, Rippe K, Ogawa S, Lübbert M. Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia. Blood Adv. 3;761–765, 2019
     
21. Barth J, Abou-El-Ardat K, Dalic D, Kurrle N, Maier AM, Mohr S, Schütte J, Vassen L, Greve G, Schulz-Fincke J, Schmitt M, Tosic M, Metzger E, Bug G, Khandanpour C, Wagner SA, Lübbert M, Jung M, Serve H, Schüle R, Berg T. LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML. Leukemia. 33:1411-1426, 2019
     
22. Blagitko-Dorfs N, Schlosser P, Greve G, Pfeifer D, Meier R, Baude A, Brocks D, Plass C., Lübbert M. Combination Treatment of Acute Myeloid Leukemia Cells with DNMT and HDAC Inhibitors: Predominant Synergistic Gene Downregulation Associated with Gene Body Demethylation.
    Leukemia. 33:945-956, 2019.
     
23. Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C. RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia. Nat Commun. 8:2126, 2017
     
24. Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C. DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet. 49:1052-1060, 2017.
     
25. Hiller JK, Schmoor C, Gaidzik VI, Schmidt-Salzmann C, Yalcin A, Abdelkarim M, Blagitko-Dorfs N, Döhner K, Bullinger L, Duyster J, Lübbert M, Hackanson B. Evaluating the impact of genetic and epigenetic aberrations on survival and response in acute myeloid leukemia patients receiving epigenetic therapy. Ann Hematol. 96:559-565, 2017.
     
26. Lübbert M, Ihorst G, Sander PN, Bogatyreva L, Becker H, Wijermans PW, Suciu S, Bissé E, Claus R. Elevated fetal haemoglobin is a predictor of better outcome in MDS/AML patients receiving 5-aza-2'-deoxycytidine (Decitabine). Br J Haematol. 176:609-617, 2017.
     
27. Madan V, Shyamsunder P, Han L, Mayakonda A, Nagata Y, Sundaresan J, Kanojia D, Yoshida K, Ganesan S, Hattori N, Fulton N, Tan KT, Alpermann T, Kuo MC, Rostami S, Matthews J, Sanada M, Liu LZ, Shiraishi Y, Miyano S, Chendamarai E, Hou HA, Malnassy G, Ma T, Garg M, Ding LW, Sun QY, Chien W, Ikezoe T, Lill M, Biondi A, Larson RA, Powell BL, Chng WJ, Tien HF, Heuser M, Ganser A, Koren-Michowitz M, Kornblau SM, Kantarjian HM, Nowak D, Hofmann WK, Yang H, Stock W, Ghavamzadeh A, Alimoghaddam K, Haferlach T, Ogawa S, Shih LY, Mathews V, Koeffler HP. Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia. 30:1672-81, 2016.
     
28. Greve G, Schiffmann I, Pfeifer D, Pantic M, Schüler J, Lübbert M. The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells. BMC Cancer. 15:947, 2015
     
29. Greve G, Schiffmann I, Lübbert M. Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid. J Cancer Res Clin Oncol. 141:2171-80, 2015
     
30. Becker H, Yoshida K, Blagitko-Dorfs N, Claus R, Pantic M, Abdelkarim M, Niemöller C, Greil C, Hackanson B, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Döhner K, Schnittger S, Henneke P, Niemeyer CM, Flotho C, Pfeifer D, Ogawa S, Lübbert M. Tracing the development of acute myeloid leukemia in CBL-syndrome. Blood. 123:1883-1886, 2014
     
31. Blagitko-Dorfs N, Jiang Y, Duque-Afonso J, Hiller J, Yalcin A, Greve G, Abdelkarim M, Hackanson B, Lübbert M. Epigenetic Priming of AML Blasts for All-trans Retinoic Acid-Induced Differentiation by the HDAC Class-I Selective Inhibitor Entinostat. PLoS One. 8(10):e75258, 2013
     
32. Solari L, Bauer T, Dicker F, Haferlach C, Grießhammer M, Schnittger S, Becker H, Lübbert M. A Novel Recurrent AML1-ETO fusion: Tight in vivo Association with BCR-ABL1. Leukemia. 27(6): 1397-400, 2013
     
33. Claus R, Pfeifer D, Almstedt M, Zucknick M, Hackanson B, Plass C, Lübbert M. Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia. Leuk. Res. 37(2):190-6, 2013
     
34. Hackanson B, Rimmele L, Benkißer M, Abdelkarim M, Fliegauf M, Jung M, Lübbert M. HDAC6 as a target for antileukemic drugs in acute myeloid leukemia. Leuk. Res. 36(8):1055-62, 2012.

Selected clinical publications (2012 – 2023)

1. Efficace F, Kicinski M, Coens C, Suciu S, van der Velden WJFM, Noppeney R, Chantepie SP, Griskevicius L, Neubauer A, Audisio E, Luppi M, Fuhrmann S, Foà R, Crysandt M, Gaidano G, Vrhovac R, Venditti A, Posthuma EFM, Candoni A, Baron F, Legrand O, Mengarelli A, Fazi P, Vignetti M, Giraut A, Wijermans PW, Huls GA, Lübbert M. Decitabine in Older Patients with AML: Quality of Life Results of the EORTC-GIMEMA-GMDS-SG Randomized Phase III Trial. Blood. 2024 May 8: blood. 2023023625.
   doi: 10.1182/blood.2023023625. PMID: 38717861.
    
2. Javorniczky NR, Grishina O, Hund I, Pantic M, Pfeifer D, Schmoor C, Thomas J, Duyster J, Becker H, Lübbert M. Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics. Clin Epigenetics. 2023 Nov 28;15(1):185.
   doi: 10.1186/s13148-023-01596-5. PMID: 38012682; PMCID: PMC10683313.
    
3. Lübbert M, Wijermans PW, Kicinski M, Chantepie S, Van der Velden WJFM, Noppeney R, Griškevičius L, Neubauer A, Crysandt M, Vrhovac R, Luppi M, Fuhrmann S, Audisio E, Candoni A, Legrand O, Foà R, Gaidano G, van Lammeren-Venema D, Posthuma EFM, Hoogendoorn M, Giraut A, Stevens-Kroef M, Jansen JH, de Graaf AO, Efficace F, Ammatuna E, Vilque JP, Wäsch R, Becker H, Blijlevens N, Dührsen U, Baron F, Suciu S, Amadori S, Venditti A, Huls G; EORTC Leukemia Group, GIMEMA, and German MDS Study Group. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial. Lancet Haematol. 2023 Nov;10(11):e879-e889, PMID: 37914482 Clinical Trial.

4. Montesinos P, Sossa-Melo C. Decitabine versus intensive chemotherapy induction for older patients with acute myeloid leukaemia: a futile but successful trial. Lancet Haematol., Commentary, 2023 Nov;10(11):e866-e867.

5. Döhner H, Weber D, Krzykalla J, Fiedler W, Kühn MWM, Schroeder T, Mayer K, Lübbert M, Wattad M, Götze K, Fransecky L, Koller E, Wulf G, Schleicher J, Ringhoffer M, Greil R, Hertenstein B, Krauter J, Martens UM, Nachbaur D, Samra MA, Machherndl-Spandl S, Basara N, Leis C, Schrade A, Kapp-Schwoerer S, Cocciardi S, Bullinger L, Thol F, Heuser M, Paschka P, Gaidzik VI, Saadati M, Benner A, Schlenk RF, Döhner K, Ganser A; German–Austrian AML Study Group. Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09-09): a randomised, open-label, multicentre, phase 3 trial. Lancet Haematol., 2023 Jul;10(7):e495-e509, PMID: 37187198 Clinical Trial.

6. Rummelt C, Grishina O, Schmoor C, Crysandt M, Heuser M, Götze KS, Schlenk RF, Döhner K, Salih HR, Heil G, Müller-Tidow C, Brugger W, Kündgen A, De Wit M, Giagounidis A, Scholl S, Neubauer A, Krauter J, Bug G, Al-Ali HK, Wäsch R, Becker H, May AM, Duyster J, Hackanson B, Ganser A, Döhner H, Lübbert M. Activity of decitabine combined with all-trans retinoic acid in oligoblastic AML: Results from a randomized 2x2 phase II trial (DECIDER). Haematologica. DOI:10.3324/haematol.2022. 282258 Published January 2023

7. Kreutmair S, Pfeifer D, Waterhouse M, Takács F, Graessel L, Döhner K, Duyster J, Illert AL, Frey AV, Schmitt M, Lübbert M. First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience. Cancer Immunol Immunother. 71(12):2913-2928, 2022

8. Stomper J, Richter-Pechanska P, Pfeifer D, Andolfo I, Iolascon A, Muckenthaler MU, Lübbert M. Deferasirox-induced robust and dose-dependent reversal of anemia in a patient with variants in the TRIB2 and ABCB6 genes.
   Blood Adv. 6(11):3551-3555, 2022

9. Lübbert M, Grishina O, Schmoor C, Schlenk RF, Jost E, Crysandt M, Heuser M, Thol F, Salih HR, Schittenhelm MM, Germing U, Kuendgen A, Götze KS, Lindemann H-W, Müller-Tidow C, Heil G, Scholl S, Bug G, Schwänen C, Giagounidis A, Neubauer A, Krauter J, Brugger W, de Wit M, Wäsch R, Becker H, May AM, Duyster J, Döhner K, Ganser A, Hackanson B, Döhner H. Valproate and retinoic acid in combination with decitabine in elderly nonfit patients with acute myeloid leukemia: Results of a multicenter, randomized, 2 × 2, phase II trial.. J Clin Oncol. 38:257-270, 2020.
    
10. Metzelder SK, Schroeder T, Lübbert M, Ditschkowski M, Götze K, Scholl S, Meyer RG, Dreger P, Basara N, Fey MF, Salih HR, Finck A, Pabst T, Giagounidis A, Kobbe G, Wollmer E, Finke J, Neubauer A, Burchert A. Long-term survival of sorafenib-treated FLT3-ITD-positive acute myeloid leukaemia patients relapsing after allogeneic stem cell transplantation. Eur J Cancer. 86:233-239, 2017
     
11. Schlenk RF, Lübbert M, Benner A, Lamparter A, Krauter J, Herr W, Martin H, Salih HR, Kündgen A, Horst HA, Brossart P, Götze K, Nachbaur D, Wattad M, Köhne CH, Fiedler W, Bentz M, Wulf G, Held G, Hertenstein B, Salwender H, Gaidzik VI, Schlegelberger B, Weber D, Döhner K, Ganser A, Döhner H; German-Austrian Acute Myeloid Leukemia Study Group. All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study. Ann Hematol. 95:1931-1942, 2016.
     
12. Lübbert M, Suciu S, Hagemeijer A, Rüter B, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, Muus P, Pflüger KH, Schaefer HE, Bogatyreva L, Aul C, de Witte T, Ganser A, Becker H, Huls G, van der Helm L, Vellenga E, Baron F, Marie JP, Wijermans PW. Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: Results of a Subgroup Analysis of the Randomized Phase III Study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group. Ann Hematol. 95:191-9, 2016.
     
13. Becker H, Suciu S, Rüter BH, Platzbecker U, Giagounidis A, Selleslag D, Labar B, Germing U, Salih HR, Muus P, Pflüger, K-H, Hagemeijer A, Schaefer H-E, Baron F, Ganser A, Aul C, de Witte T, Wijermans PW, Lübbert M. Decitabine vs. Best Supportive Care in Older Patients With Refractory Anaemia With Excess Blasts in Transformation (RAEBt), or Low Blast Count Acute Myeloid Leukaemia (AML) According to World Health Organization Criteria.
    Ann Hematol. 94:2003-13, 2015
     
14. Steinmann J, Bertz H, Wäsch R, Marks R, Zeiser R, Bogatyreva L, Finke J, Lübbert M. 5-Azacytidine and DLI can induce long-term remissions in AML patients relapsed after allograft. Bone Marrow Transplant. 50:690-5, 2015.
     
15. Döhner H, Lübbert M, Fiedler W, Fouillard L, Haaland A, Brandwein JM, Lepretre S, Reman O, Turlure P, Ottmann OG, Müller-Tidow C, Krämer A, Raffoux E, Döhner K, Schlenk RF, Voss F, Taube T, Fritsch H, Maertens J. Randomized, phase 2 trial comparing low-dose cytarabine with or without volasertib in AML patients not suitable for intensive induction therapy. Blood. 124:1426-33, 2014.
     
16. Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, Specchia G, Sica S, Divona M, Levis A, Fiedler W, Cerqui E, Breccia M, Fioritoni G, Salih HR, Cazzola M, Melillo L, Carella AM, Brandts CH, Morra E, von Lilienfeld-Toal M, Hertenstein B, Wattad M, Lübbert M, Hänel M, Schmitz N, Link H, Kropp MG, Rambaldi A, La Nasa G, Luppi M, Ciceri F, Finizio O, Venditti A, Fabbiano F, Döhner K, Sauer M, Ganser A, Amadori S, Mandelli F, Döhner H, Ehninger G, Schlenk RF, Platzbecker U; Gruppo Italiano Malattie Ematologiche dell'Adulto. German-Austrian Acute Myeloid Leukemia Study Group. Study Alliance Leukemia, Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.
    N. Engl. J. Med. 369:111-21, 2013
     
17. Lübbert M, Rüter BH, Claus R, Schmoor C, Schmid M,  Germing U, Kuendgen A, Rethwisch V, Ganser A, Platzbecker U, Galm O, Brugger W, Heil G, Hackanson B, Deschler B, Döhner K, Hagemeijer A, Wijermans PW, Döhner H. A multicenter phase II trial of continued Decitabine as first-line treatment of older AML patients judged unfit for induction chemotherapy. Haematologica. 97:393-401, 2012