Remi Peyronnet, PhD
Head of Mechanobiology
Contact
remi.peyronnet@uniklinik-freiburg.de
+49 (0)761 270 63953
Research Interests:
- Identification and characterisation of cardiac cell mechano-sensors
- Mechano-stimulation of cells and tissues
- Characterisation of the adaptation of biological processes to mechanical forces
- Characterisation of cell and tissue mechanical properties in different mechanical environment
Brief CV:
Rémi studied physiology at the Limoges Faculty of Science and Technology (2000-2004), and then he completed his Master and PhD at the Orsay Faculty of Science (Paris XI) in 2005 and 2009, respectively. In 2010, he joined Dr Eric Honoré at the Institute of Molecular and Cellular Pharmacology (IPMC), Sophia-Antipolis, with the support of an AFM (Association Française contre les Myopathies) Postdoctoral Research Fellowship to investigate the role and relevance of mechano-transduction mechanisms in Autosomal Dominant Polycystic Kidney Disease. In 2013, he obtained an Imperial College’s Junior Research Fellowship and joined Prof. Peter Kohl’s group to identify mechano-sensors in heart valves. Since 2016 Rémi Peyronnet heads the Cell Biophysics section at the IEKM in Freiburg.
Selected Publications:
- Künzel SR [...] Dudek S, Emig R, Ravens U, Rog-Zielinska EA, Peyronnet R, El-Armouche A. Modeling atrial fibrosis in vitro-Generation and characterization of a novel human atrial fibroblast cell line. FEBS Open Bio 2020/10:1210-1218
- Darkow E, Rog-Zielinska EA, Madl J [...] Kohl P, Ravens U, Römer W, Peyronnet R. The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes. Front Physiol 2020/11:457
- Emig R, Zgierski-Johnston CM, Beyersdorf F, Rylski B, Ravens U, Weber W, Kohl P, Hörner M, Peyronnet R. Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness. Front Physiol 2020/10:1526
- Peyronnet R, Ravens U. Atria-selective antiarrhythmic drugs in need of alliance partners. Pharmacol Res 2019/145:104262
- Schmitt R, Tscheuschler A [...] Peyronnet R, Kari FA. A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2. PLoS One 2019/14:e0212859
- Odening KE, Bodi I [...] Perez-Feliz S, Fürniss H, Mettke L, Michaelides K [...] Peyronnet R [...] Bode C, Jolivet G, Brunner M. Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/APD shortening in the atria and ventricles and increased VT/VF inducibility. Eur Heart J 2019/40:842-853
- Klesen A, Jakob D, Emig R, Kohl P, Ravens U, Peyronnet R. Cardiac fibroblasts: Active players in (atrial) electrophysiology? Herzschrittmacherther Elektrophysiol 2018/29:62-69
- Rog-Zielinska EA and Peyronnet R. Cardiac mechanics and electrics: It takes two to tango. Prog Biophys Mol Biol 2017/130:121-123
- Peyronnet R, Bollensdorff C, Capel RA, Rog-Zielinska EA, Woods CE, Charo DN, Lookin O, Fajardo G, Ho M, Quertermous T, Ashley EA, Kohl P. Load-dependent effects of apelin on murine cardiomyocytes. Prog Biophys Mol Biol 2017/130:333-343
- Burton RAB, Rog-Zielinska EA, Corbett AD, Peyronnet R, Bodi I, Fink M, Sheldon J, Hoenger A, Calaghan SC, Bub G, Kohl P. Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation. Biophys J 2017/113:1047-1059
- Decher N, Ortiz-Bonnin B [...] Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P [...] Schulze-Bahr E. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia. EMBO Mol Med 2017/9:403-414
- Peyronnet R, Nerbonne J, Kohl P. Cardiac mechano-gated ion channels and arrhythmias. Circ Res 2016/118:311-329
- Lohezic M, Teh I, Bollensdorff C, Peyronnet R, Hales PW, Grau V, Kohl P & Schneider JE. Interrogation of living myocardium in multiple static deformation states with diffusion tensor and diffusion spectrum imaging. Prog Biophys Mol Biol 2014/115:213-2259
- Peyronnet R*, Martins JR* [...] Patel A. Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep 2013/14:1143-8
- Peyronnet R, Sharif-Naeini R [...] Duprat F. Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K2P channels. Cell Rep 2012/1:1-10
- Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL Jr. Multiple modalities converge on a common gate to control K2P channel function. EMBO J 2011/30:3594-606
- Moha ou Maati H, Peyronnet R [...] Heurteaux C, Borsotto M. A human TREK-1/HEK cell line: a highly efficient screening tool for drug development in neurological diseases. PLoS One 2011/6:e25602
- Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL Jr. Multiple modalities converge on a common gate to control K2P channel function. EMBO Journal 2011/30:3594-606
- Haswell ES* Peyronnet R*, Barbier-Brygoo H, Meyerowitz EM and Frachisse J-M. Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root. Curr Biol 2008/18:730–734
*these authors contributed equally