MEC 2019
Wednesday, 4 September 2019
Keynote Lectures and Festive OpeningChair: Ursula Ravens (IEKM, Freiburg) |
Peter Kohl (Director of Research of the University Heart Centre Freiburg-Bad Krozingen, Director of the IEKM) Welcome addresses |
Donald M. Bers (UC Davis Health) Orchestrating nanodomain signals for the integrated cardiac fight-or-flight response |
Thomas Eschenhagen (UKE Hamburg) Cardiac mechanics matters: models and muddles |
Wrap-up |
Reception Prometheus Hall |
Thursday, 5 September 2019
Registration |
Remi Peyronnet (IEKM, Freiburg) Greeting |
Session 1: Mechano-Sensitive Ion ChannelsChair: Remi Peyronnet (IEKM, Freiburg) |
Jack Rubinstein (Cincinatti) TRP channels as regulators of cardiac hypertrophy |
Marc Freichel (Heidelberg) Regulating pathological cardiac remodeling via TRPC channels and new players in endo-lysosomal Ca2+ signaling |
Niels Decher (Marburg) Arrhythmogenic mutation in human TREK-1: conversion of a SAK to a hypersensitive SAC |
Coffee and Posters |
Frederick Sachs (SUNY Buffalo) Drug efficacy is a function of bilayer tension |
Boris Martinac (Sydney) The role of Piezo1 in cardiac hypertrophy |
Lunch and Posters |
Session 2: Stretch Effects on other Molecular MechanismsChair: Gudrun Antoons (Maastricht) |
Thomas Iskratsch (London) Roles of muscle and non-muscle myosin contractions |
Farah Sheikh (UCSD) Mechanical modulation of cell junctions: relevance for cardiac electrophysiology |
Michele Miragoli (Parma) Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders |
Tea and Posters |
Gentaro Iribe (Okayama) Role of nucleotide signalling in mechano-sensitive responses of organelle and cellular mechanisms |
Kenneth Campbell (Kentucky) Length-dependent activation in human material |
Jia Li (Poster 09) Stretch Synchronizes Sarcomere Shortening in Cardiomyocytes: Implications for Frank-Starling Mechanism |
Elaheh Zare-Eelanjegh (Poster 08) Fluid Force Microscopy for Micro-Manipulation of Single Cardiac Muscle Cells |
Poster Session |
Posters with refreshments, and nibbles, and more… |
Friday, 6 September 2019
Session 3: Methods and Concepts for Quantifying Cardiac MechanicsChair: Delphine Dean (Clemson) |
Michael Gotthardt (MDC, Berlin) A Visual and Biomechanical Approach to Sarcomere Dynamics |
Ramona Emig (IEKM, Freiburg) Hydrogels with Light-Tunable Stiffness as a Novel Research Tool for Cardiac Mechanobiology |
Ye Chen-Izu (UC Davis) Mechanical Load Effects on Cardiomyocyte Action Potential and Arrhythmogenic Activities |
Coffee and Posters |
Periklis Pantazis (London) GenEPi:Piezo1-Based Fluorescent Reporter for Visualizing Mechanical Stimuli with High Spatiotemporal Resolution |
Leonardo Sacconi (Florence) Random Access Confocal Microscopy for Cardiac Research |
Lunch and Posters |
Session 4: Cell and Tissue Level MECChair: Alex Quinn (Halifax) |
Anastasia Khokhlova (Yekaterinburg) Transmural Differences in Single Cardiomyocyte Electro-Mechanics |
Takuro Tomita (Matsumoto) Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness |
Diane Fatkin (Sydney) Atrial Endocardial TRPC6 Channels and Load-Dependent Endocardial/Myocardial Cross-Talk |
Tea and Posters |
Kate Herum (UCSD) Mechanical Regulation of Cardiac Fibroblast Phenotypes |
William Louch (Oslo) Understanding Plasticity of Dyadic Structure and Function |
Breanne Cameron (Poster 25) Cellular Mechanisms of Mechano-Arrhythmogenicity During Acute Ischemia |
Ana Simon-Chica (Poster 06) Stretch-Activated Channels Modulate the Activity of Resident and Bone Marrow Derived Cardiac Macrophages |
Meeting Photo |
Saturday, 7 September 2019
Session 5: MEC & Arrhythmias: Organ LevelChair: Andrew McCulloch (UCSD) |
Eilidh MacDonald (Halifax) MEC in Zebrafish: Utility and Limitations for pacemaker studies |
Callum Johnston (IEKM, Freiburg) Opto-Acoustic Imaging of 3D Cardiac Electrophysiology |
Coffee and Posters |
Denis Loiselle (Auckland) Frank-Starling reloaded |
Jeffrey Holmes (Virginia) Mechanics, Dynamics and Therapeutic Modification of Myocardial Infarct Scar |
Lunch and Posters |
Session 6: MEC & Arrhythmias: Translational AspectsChair: Crystal Ripplinger (UC Davis) |
Paul Volders (Maastricht) Neuro-Mechanical Cross-Talk in Proarrhythmia of Drug-Induced Long-QT Syndrome |
Pier Lambiase (London) Structural Remodeling and Conduction Velocity Dynamics in Human Left Atrium: Relation with Re-entrant Mechanisms Sustaining AF |
Esther Pueyo (Zaragoza) The interplay of Autonomic and Mechanical Modulation of Ventricular Repolarization in Human |
Tea and Posters |
Closing SessionChair: Peter Kohl (IEKM), Mark Marshall (Medtronic) |
Thomas Eschenhagen (UKE Hamburg) What we've learned and what should we focus on next in terms of clinical relevance |
Donald M. Bers (UC Davis Health) What we've learned and what should we focus on next in terms of mechanisms |
Discussion, Participant feedback |
Meeting Dinner at Peterhofkeller |
Reception |
Poster Awards |
Dinner |