Klinik für Allgemein- und Viszeralchirurgie

Beruflicher Werdegang, Ausbildung und Berufserfahrung

Akademischer Werdegang

Forschungsschwerpunkte

• Chirurgie von Leber- und Gallenwegstumoren
• Auswirkungen von oxidativem Stress nach Ischämie Reperfusion
• Ischämie Reperfusionsschaden nach Pankreastransplantation

Klinische Schwerpunkte

• Chirurgischer Leiter Kolorektale Chirurgie, Chirurgie von kolorektalen Karzinomen, Chirurgie chronisch entzündlicher Darmerkrankungen (CED)
• Chirurgie peritonealer Malignome inkl. Zytoreduktive Chirurgie / HIPEC / PIPAC
• Leiter des zertifizierten Darmkrebszentrums am CCCF
• Leberchirurgie
• Metastasenchirurgie, chirurgischer Leiter des Metastasenzentrums
• Transplantationschirurgie

Publikationen (Auszug)

Hasselblatt P, Reindl W, Gauss A, Neeff H, Fusco S, Klaus J. Questions to consider when caring for patients with ulcerative colitis. Z Gastroenterol. 2023 Jun;61(6):690-700. English. Epub 2022 Oct 18. PMID:36257329.

Schmidt A, Neeff HP, Quante M. Endoscopic R1/Rx Resection of T1 Colorectal Cancer-What Next? Am J Gastroenterol. 2022 Apr 1;117(4):603-604. PMID: 35103021

Neeff HP. Versorgung des kolorektalen Karzinoms in England: Daten aus dem ersten Lockdown 2020. Coloproctology. 2021;43(3):231-232. Epub 2021 Apr 20. PMID: 33897077; PMCID: PMC8057001

Brunner TB, Bettinger D, Schultheiss M, Maruschke L, Sturm L, Bartl N, Koundurdjieva I, Kirste S, Neeff HP, Goetz C, Nicolay NH, Ihorst G, Bamberg F, Thimme R, Grosu AL, Gkika E. Efficacy of Stereotactic Body Radiotherapy in Patients With Hepatocellular Carcinoma Not Suitable for Transarterial Chemoembolization (HERACLES: HEpatocellular Carcinoma Stereotactic RAdiotherapy
CLinical Efficacy Study). Front Oncol. 2021 Mar 19;11:653141. PMID: 33816309; PMCID: PMC8017336

Spiegelberg J, Neeff H, Holzner P, Runkel M, Fichtner-Feigl S, Glatz T. Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer. World J Gastrointest Oncol. 2020 Aug 15;12(8):903-917.  PMID: 32879667; PMCID: PMC7443840

änigen BM, Hempel J, Holzner P, Schneider J, Fichtner-Feigl S, Thomusch O, Neeff H, Pisarski P, Glatz T. Simultaneous ipsilateral nephrectomy during kidney transplantation in autosomal dominant polycystic kidney disease: a matched pair analysis of 193 consecutive cases. Langenbecks Arch Surg. 2020 Sep;405(6):833-842.  Epub 2020 Jul 23. PMID:32705344; PMCID: PMC7471159

Thiele JR, Weber J, Neeff HP, Manegold P, Fichtner-Feigl S, Stark GB, Eisenhardt SU. Reconstruction of Perineal Defects: A Comparison of the Myocutaneous Gracilis and the Gluteal Fold Flap in Interdisciplinary Anorectal Tumor Resection. Front Oncol. 2020 May 6;10:668. PMID: 32435617; PMCID: PMC7218107

Joechle K, Gkika E, Grosu AL, Hopt UT, Neeff HP, Fichtner-Feigl S, Lang SA. Intraoperative Strahlentherapie in der Abdominalchirurgie – eigene Erfahrungen [Intraoperative radiotherapy in abdominal surgery-Own experiences]. Chirurg. 2020 Nov;91(11):962-969. German. PMID: 32270223; PMCID: PMC7581588

Manegold P, Taukert J, Neeff H, Fichtner-Feigl S, Thomusch O. The minimum distal resection margin in rectal cancer surgery and its impact on local recurrence - A retrospective cohort analysis. Int J Surg. 2019 Sep;69:77-83. Epub 2019 Jul 27. PMID: 31362126.

Koulaxouzidis G, Penna V, Bannasch H, Neeff HP, Manegold P, Aigner F, Witzel C, Kreis ME, Pratschke J, Stark GB, Lampert FM. The adipofasciocutaneous gluteal fold perforator flap a versatile alternative choice for covering perineal defects. Int J Colorectal Dis. 2019 Mar;34(3):501-511. PMID: 30610436.

Holzner PA, Makowiec F, Klock A, Glatz T, Fichtner-Feigl S, Lang SA, Neeff HP. Outcome after hepatic resection for isolated non-colorectal, non-neuroendocrine liver metastases in 100 patients - the role of the embryologic origin of the primary tumor. BMC Surg. 2018 Oct 29;18(1):89 PMID: 30373582.

Gkika E, Strouthos I, Kirste S, Adebahr S, Schultheiss M, Bettinger D, Fritsch R, Brass V, Maruschke L, Neeff HP, Lang SA, Nestle U, Grosu AL, Brunner TB. Repeated SBRT for in- and out-of-field recurrences in the liver. Wiederholte SBRT bei In- und Out-of-field Rezidiven der Leber. Strahlenther Onkol. 2019 Mar;195(3):246-253. English. PMID: 30353350.

Makowiec F, Menzel M, Bronsert P, Holzner PA, Klock A, Lang SA, Fichtner-Feigl S, Neeff HP. Does the site of primary colorectal cancer influence the outcome after resection of isolated liver metastases? Dig Liver Dis. 2018 Oct;50(10):1088-1092. PMID: 30055964.

Glatz T, Neeff H, Holzner P, Fichtner-Feigl S, Thomusch O. Repair of a Grynfeltt-Lesshaft hernia with the PROCEED™ VENTRAL PATCH: a case report. Surg Case Rep. 2018 May 30;4(1):50. PMID: 29845578.

Neeff HP, Holzner PA, Menzel M, Bronsert P, Klock A, Lang SA, Fichtner-Feigl S, Hopt UT, Makowiec F. Das intrahepatische Cholangiokarzinom : Ergebnisse nach 84 Resektionen [Intrahepatic cholangiocarcinoma : Results after 84 resections]. Chirurg. 2018 May;89(5):374-380. German. PMID: 29464308.

Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R. Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood. 2018 Apr 19;131(16):1858-1869. PMID: 29463561.

Gkika E, Bettinger D, Krafft L, Schultheiss M, Neeff HP, Maruschke L, Schulenburg M, Adebahr S, Kirste S, Nestle U, Thimme R, Grosu AL, Brunner TB. The role of albumin-bilirubin grade and inflammation-based index in patients with hepatocellular carcinoma treated with stereotactic body radiotherapy. Die Rolle von Albumin-Bilirubin Grade und Inflammation-Based Index bei der stereotaktischen Therapie von Patienten mit hepatozellulären Karzinomen. Strahlenther Onkol. 2018 May;194(5):403-413. PMID: 29322205.

Gkika E, Hallauer L, Kirste S, Adebahr S, Bartl N, Neeff HP, Fritsch R, Brass V, Nestle U, Grosu AL, Brunner TB. Stereotactic body radiotherapy (SBRT) for locally advanced intrahepatic and extrahepatic cholangiocarcinoma. BMC ancer. 2017 Nov 21;17(1):781. PMID: 29162055;

Thomaschewski M, Neeff H, Keck T, Neumann HPH, Strate T, von Dobschuetz E. Is there any role for minimally invasive surgery in NET? Rev Endocr Metab Disord. 2017 Dec;18(4):443-457. PMID: 29127554.

Makowiec F, Bronsert P, Klock A, Hopt UT, Neeff HP. Prognostic influence of hepatic margin after resection of colorectal liver metastasis: role of modern preoperative chemotherapy. Int J Colorectal Dis. 2018 Jan;33(1):71-78. PMID: 29098384.

Gkika E, Schultheiss M, Bettinger D, Maruschke L, Neeff HP, Schulenburg M, Adebahr S, Kirste S, Nestle U, Thimme R, Grosu AL, Brunner TB. Excellent local control and tolerance profile after stereotactic body radiotherapy of advanced hepatocellular carcinoma. Radiat Oncol. 2017 Jul 12;12(1):116. PMID: 28701219

Gkika E, Tanadini-Lang S, Kirste S, Holzner PA, Neeff HP, Rischke HC, Reese T, Lohaus F, Duma MN, Dieckmann K, Semrau R, Stockinger M, Imhoff D, Kremers N, Häfner MF, Andratschke N, Nestle U, Grosu AL, Guckenberger M, Brunner TB. Interobserver variability in target volume delineation of hepatocellular carcinoma : An analysis of the working group "Stereotactic Radiotherapy" of the German Society for Radiation Oncology (DEGRO). Interobservervariabilität bei der Zielvolumendefinition für hepatozelluläre Karzinome : Eine Analyse der Arbeitsgruppe „Stereotaktische Radiotherapie“ der Deutschen Gesellschaft für Radioonkologie (DEGRO). Strahlenther Onkol. 2017 Oct;193(10):823-830. PMID: 28695316.

Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Höppner J, Hopt UT, Makowiec F. Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer. J Gastrointest Surg. 2016 Oct;20(10):1707-15. PMID: 27384432. Schultheiss M, Neeff HP, Neumann-Haefelin C. Sigmoid Colon Compression Due to Liver Migration and Hypertrophy. Clin Gastroenterol Hepatol. 2016 Aug;14(8):A27. PMID: 27165468.

Lutz L, Holzner P, Neeff H. An Unusual Cecal Mass in an Otherwise Healthy Young Woman. Gastroenterology. 2016 May;150(5):e5-e6. PMID: 27025673.  Sauerbuch T, Hopt UT, Neeff H, Pötzsch B, Rössle M, Valla D. Management of Portal/Mesenteric Vein Occlusion. Viszeralmedizin. 2014 Dec;30(6):417-20. PMID: 26468305 Meyer S, Neeff H, Thomusch O, Strate T, Tittelbach-Helmrich D, Hopt UT, von Dobschuetz E. Everolimus Improves Microcirculatory Derangements in Experimental Postischemic Pancreatitis Modulating the Expression of Vascular Endothelial Growth Factor, Interleukin 6, and Toll-Like Receptor 4. Pancreas. 2015 Nov;44(8):1245-51. PMID: 26390417.

Schultheiß M, Bettinger D, Neeff HP, Brunner TB, Thimme R. Das hepatozelluläre Karzinom--Therapieoptionen 2015 [Hepatocellular Carcinoma: therapeutic options 2015]. Dtsch Med Wochenschr. 2015 Jul;140(14):1063-8. German. PMID: 26182255.

Riediger H, Adam U, Utzolino S, Neeff HP, Hopt UT, Makowiec F. Perioperative outcome after pancreatic head resection: a 10-year series of a specialized surgeon in a university hospital and a community hospital. J Gastrointest Surg. 2014 Aug;18(8):1434-40. PMID: 24898516

Neeff HP, Streule GC, Drognitz O, Tittelbach-Helmrich D, Spangenberg HC, Hopt UT, Makowiec F. Early mortality and long-term survival after abdominal surgery in patients with liver cirrhosis. Surgery. 2014 Apr;155(4):623-32 PMID: 24468037.

Jilg CA, Drendel V, Bacher J, Pisarski P, Neeff H, Drognitz O, Schwardt M, Gläsker S, Malinoc A, Erlic Z, Nunez M, Weber A, Azurmendi P, Schultze-Seemann W, Werner M, Neumann HP. Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens. Nephron Clin Pract. 2013;123(1-2):13-21. PMID: 23752029.

Drognitz O, Holzner P, Glatz T, Hopt UT, Neeff H. [The surgical technique of laparoscopic right hemihepatectomy. Technical aspects and results]. Chirurg. 2014 Feb;85(2):139-46. doi: 10.1007/s00104-013-2672-z. German. PubMed PMID: 24435832.

Neeff HP, Drognitz O, Holzner P, Klock A, Bronsert P, Hopt UT, Makowiec F. Outcome after repeat resection of liver metastases from colorectal cancer. Int J Colorectal Dis. 2013 Aug;28(8):1135-41. doi: 10.1007/s00384-013-1670-4. Epub 2013 Mar 7. PubMed PMID: 23468250.

Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, Hoffmann MM, Ortiz-Bruechle N, Glasker S, Pisarski P, Neeff H, Krämer-Guth A, Cybulla M, Hornberger M, Wilpert J, Funk L, Baumert J, Paatz D, Baumann D, Lahl M, Felten H, Hausberg M, Zerres K, Eng C; Else-Kroener-Fresenius-ADPKD-Registry. Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrol Dial Transplant. 2013 Jun;28(6):1472-87. doi:10.1093/ndt/gfs551. Epub 2013 Jan 8. PubMed PMID: 23300259.

Neeff HP, Sommer O, Meyer S, Tinelli A, Scholtes M, Hopt UT, Drognitz O, von Dobschuetz E. Blood modulates the kinetics of reactive oxygen release in pancreatic ischemia-reperfusion injury. Pancreas. 2012 Oct;41(7):1105-11. doi: 10.1097/MPA.0b013e318249c378. PubMed PMID: 22617706.

Neeff HP, Drognitz O, Klock A, Illerhaus G, Opitz OG, Hopt UT, Makowiec F. Impact of preoperative targeted therapy on postoperative complications after resection of colorectal liver metastases. Int J Colorectal Dis. 2012 May;27(5):635-45. doi: 10.1007/s00384-011-1360-z. Epub 2011 Dec 6. PubMed PMID: 22139030.

Neeff H, Mariaskin D, Spangenberg HC, Hopt UT, Makowiec F. Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s using Child and MELD scores. J Gastrointest Surg. 2011 Jan;15(1):1-11. doi: 10.1007/s11605-010-1366-9. PubMed PMID: 21061184.

Makowiec F, Möhrle S, Neeff H, Drognitz O, Illerhaus G, Opitz OG, Hopt UT, zur Hausen A. Chemotherapy, liver injury, and postoperative complications in colorectal liver metastases. J Gastrointest Surg. 2011 Jan;15(1):153-64. doi: 10.1007/s11605-010-1368-7. PubMed PMID: 21061183.

Hopt UT, Drognitz O, Neeff H. [Timing of resection in patients with colorectal carcinoma and synchronous liver metastases]. Zentralbl Chir. 2009 Sep;134(5):425-9. doi: 10.1055/s-0029-1224612. Epub 2009 Sep 15. Review. German. PubMed PMID: 19757342.

Neeff H, Hörth W, Makowiec F, Fischer E, Imdahl A, Hopt UT, Passlick B. Outcome after resection of hepatic and pulmonary metastases of colorectal cancer. J Gastrointest Surg. 2009 Oct;13(10):1813-20. doi: 10.1007/s11605-009-0960-1. Epub 2009 Jul 11. PubMed PMID: 19593668.

Neeff H, Makowiec F, Harder J, Gumpp V, Klock A, Thimme R, Drognitz O, Hopt UT. [Hepatic resection for hepatocellular carcinoma--results and analysis of the current literature]. Zentralbl Chir. 2009 Apr;134(2):127-35. doi:10.1055/s-0028-1098881. Epub 2009 Apr 20. Review. German. PubMed PMID: 19382043.

Drognitz O, Obermaier R, von Dobschuetz E, Pisarski P, Neeff H. Pancreas transplantation and ischemia-reperfusion injury: current considerations. Pancreas. 2009 Mar;38(2):226-7. doi: 10.1097/MPA.0b013e3181788e2b. PubMed PMID:19238025.

Neeff HP, von Dobschuetz E, Sommer O, Hopt UT, Drognitz O. In vivo quantification of oxygen-free radical release in experimental pancreas transplantation. Transpl Int. 2008 Nov;21(11):1081-9. doi: 10.1111/j.1432-2277.2008.00740.x. Epub 2008 Jul 25. PubMed PMID: 18699844.

Semmelmann A, Neeff H, Sommer O, Thomusch O, Hopt UT, von Dobschuetz E. Evaluation of preservation solutions by ESR-spectroscopy: superior effects of University of Wisconsin over Histidine-Tryptophan-Ketoglutarate in reducing renal reactive oxygen species. Kidney Int. 2007 May;71(9):875-81. Epub 2007 Feb 21. PubMed PMID: 17311072.

Neeff HP, Drognitz O, Holzner P, Klock A, Bronsert P, Hopt UT, Makowiec F. Outcome after repeat resection of liver metastases from colorectal cancer. Int J Colorectal Dis. 2013 Mar 7. [Epub ahead of print] PubMed PMID: 23468250.

Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, Hoffmann MM, Ortiz-Bruechle N, Glasker S, Pisarski P, Neeff H, Krämer-Guth A, Cybulla M, Hornberger M, Wilpert J, Funk L, Baumert J, Paatz D, Baumann D, Lahl M, Felten H, Hausberg M, Zerres K, Eng C; for the Else-Kroener-Fresenius-ADPKD-Registry. Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrol Dial Transplant. 2013 Jan 8.[Epub ahead of print] PubMed PMID: 23300259.

Neeff HP, Pisarski P, Tittelbach-Helmrich D, Karajanev K, Neumann HP, Hopt UT, Drognitz O. One hundred consecutive kidney transplantations with simultaneous ipsilateral nephrectomy in patients with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2013 Feb;28(2):466-71. doi: 10.1093/ndt/gfs118. Epub 2012 Oct 4. PubMed PMID: 23042709.

Drognitz O, Donauer J, Kamgang J, Baier P, Neeff H, Lohrmann C, Pohl M, Hopt UT, Kirste G, Pisarski P. Living-donor kidney transplantation: the Freiburg experience. Langenbecks Arch Surg. 2007 Jan;392(1):23-33. Epub 2006 Aug 19. PubMed PMID: 16924533.

Drognitz O, Michel P, Koczan D, Neeff H, Mikami Y, Obermaier R, Thiesen HJ, Hopt UT, Loebler M. Characterization of ischemia/reperfusion-induced gene expression in experimental pancreas transplantation. Transplantation. 2006 May 27;81(10):1428-34. PubMed PMID: 16732181.

Liu X, Günther L, Drognitz O, Neeff H, Adam U, Hopt UT. Persistent normoglycemia in the streptozotocin-diabetic rat by syngenic transplantation of islets isolated from a single donor with Liberase. Pancreas. 2006 Jan;32(1):9-15. PubMed PMID: 16340738.

Günther L, Liu X, Neeff H, Drognitz O, Hopt UT. Glucagon expression shift in a syngeneic single-donor intrahepatic rat islet transplantation model. Transplant Proc. 2005 Oct;37(8):3487-9. PubMed PMID: 16298637.

Neeff H, Imdahl A. [Soft-tissue tumors: primary excision or wait and see?]. MMW Fortschr Med. 2005 Feb 10;147(6):41-3. German. PubMed PMID: 15757226.

Drognitz O, Von Dobschuetz E, Kissler H, Liu X, Obermaier R, Neeff H, Hopt UT, Benz S. Organ procurement in experimental pancreas transplantation with minimal microcirculatory impairment. Eur Surg Res. 2004 Jul-Aug;36(4):185-91. PubMed PMID: 15263822.

Neeff H, Obermaier R, Technau-Ihling K, Werner M, Kurtz C, Imdahl A, Hopt UT. Solitary fibrous tumour of the liver: case report and review of the literature. Langenbecks Arch Surg. 2004 Aug;389(4):293-8. Epub 2004 Jun 19. Review. PubMed PMID: 15221390.

Drognitz O, Liu X, Obermaier R, Neeff H, von Dobschuetz E, Hopt UT, Benz S. Ischemic preconditioning fails to improve microcirculation but increases apoptotic cell death in experimental pancreas transplantation. Transpl Int. 2004 Jul;17(6):317-24. Epub 2004 Jun 24. Erratum in: Transpl Int. 2005 May;17(12):883. PubMed PMID: 15221122.

Drognitz O, Obermaier R, Liu X, Neeff H, von Dobschuetz E, Hopt UT, Benz S. Effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation. Am J Transplant. 2004 Jul;4(7):1042-50. Erratum in: Am J Transplant. 2004 Nov;4(11):1928-9. PubMed PMID: 15196060.

Liu X, Drognitz O, Neeff H, Benz S, Hopt UT. Apoptosis is caused by prolonged organ preservation and blocked by apoptosis inhibitor in experimental rat pancreatic grafts. Transplant Proc. 2004 May;36(4):1209-10. PubMed PMID:15194419.

Obermaier R, Walch A, Kurtz C, von Dobschuetz E, Adam U, Neeff H, Benz S, Hopt UT. Heterotopic pancreatitis with obstruction of the major duodenal papilla--a rare trigger of obstructive orthotopic pancreatitis. Pancreatology. 2004;4(3-4):244-8. Epub 2004 May 12. PubMed PMID: 15148443.

Jungraithmayr W, Szarzynski M, Neeff H, Haberstroh J, Kirste G, Schmitt-Graeff A, Farthmann EH, Eggstein S. Significance of total vascular exclusion for hepatic cryotherapy: an experimental study. J Surg Res. 2004 Jan;116(1):32-41. PubMed PMID: 14732347.

Eggstein S, Neeff H, Szarzynski M, Jungraithmayr W, Haberstroh J, Kirste G, Schmitt-Graeff A, Farthmann EH. Hepatic cryotherapy involving the vena cava. Experimental study in a pig liver model. Eur Surg Res. 2003 Mar-Apr;35(2):67-74. PubMed PMID: 12679614.

Wilting J, Neeff H, Christ B. Embryonic lymphangiogenesis. Cell Tissue Res. 1999 Jul;297(1):1-11. Review. PubMed PMID: 10398878.