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  • Surgical complications requiring late surgical revisions after pancreatoduodenectomy increase postoperative morbidity and mortality.Biesel EA, Kuesters S, Chikhladze S, Ruess DA, Hipp J, Hopt UT, Fichtner-Feigl S, Wittel UA. Scand J Surg. 2024 Jun;113(2):88-97.
     
  • Clinical characteristics and long-term outcomes following pancreatic injury - An international multicenter cohort study. Meijer LL, Vaalavuo Y, Regnér S, Sallinen V, Lemma A, Arnelo U, Valente R, Westermark S, An D, Moir JAG, Irwin EA, Biesel EA, Hopt UT, Fichtner-Feigl S, Wittel UA, Weniger M, Karle H, Bloemers FW, Sutton R, Charnley RM, Ruess DA, Szatmary P. Heliyon. 2023 Jun 21;9(6):e17436.

  • High serum CA19–9 preoperatively reduces POPF risk after pancreatoduodenectomy in PDAC. S. Chikhladze, J. Hipp, E. Biesel, M. Weckler, D.A. Ruess, L. Kousoulas, U. Hopt, S. Fichtner-Feigl, U.A. Wittel. Surgery in Practice and Sience 8 (2022) 100051

  • Stent-Associated Infectious Complications After Pancreatoduodenectomies Can Be Prevented by Perioperative Antibiotic Therapy: An Analysis of Single-Center Standards. Biesel EA, Chikhladze S, Ruess DA, Hopt UT, Fichtner-Feigl S, Wittel UA. Pancreas. 2022 Oct 1;51(9):1140-1145. doi: 10.1097/MPA.0000000000002166. PMID: 37078937.

  • Surgical complications requiring late surgical revisions after pancreatoduodenectomy increase postoperative morbidity and mortality. Biesel EA, Kuesters S, Chikhladze S, Ruess DA, Hipp J, Hopt UT, Fichtner-Feigl S, Wittel UA. Scand J Surg. 2023 Nov 14:14574969231206132. doi: 10.1177/14574969231206132.  PMID: 37962167.
     
  • Molecular Mechanisms of Tumor Immunomodulation in the Microenvironment of Colorectal Cancer. Plundrich D, Chikhladze S, Fichtner-Feigl S, Feuerstein R, Briquez PS. Int J Mol Sci. 2022 Mar 3;23(5):2782. doi:10.3390/ijms23052782. PMID: 35269922; PMCID: PMC8910988.
     
  • Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results. Chikhladze S, Lederer AK, Kühlbrey CM, Hipp J, Sick O, Fichtner-Feigl S, Wittel UA. Clin Exp Metastasis. 2020 Apr;37(2):313-324. doi: 10.1007/s10585-020-10029-z. Epub 2020 Feb 24. PMID: 32095913; PMCID: PMC7138763.
     
  • Targeting Mutant KRAS in Pancreatic Cancer: Futile or Promising? Biomedicines. Nollmann FI, Ruess DA. 2020 Aug 11;8(8):281. doi: 10.3390/biomedicines8080281. PMID: 32796566; PMCID: PMC7459579.
     
  • Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H.Nat Med. 2018 Jul;24(7):954-960. doi: 10.1038/s41591-018-0024-8. Epub 2018 May 28. PMID: 29808009.
     
  • Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma. Rittmann MC, Hussung S, Braun LM, Klar RFU, Biesel EA, Fichtner-Feigl S, Fritsch R, Wittel UA, Ruess DA. Sci Rep. 2021 Apr 5;11(1):7499. doi: 10.1038/s41598-021-86779-x. PMID: 33820913; PMCID: PMC8021576.
     
  • Immunological effects of hybrid minimally invasive versus conventional open pancreatoduodenectomy - A single center cohort study. Pancreatology. Himmelsbach R, Landerer A, Hipp J, Hopt UT, Fichtner-Feigl S, Wittel UA, Ruess DA. 2021 Aug;21(5):965-974. doi: 10.1016/j.pan.2021.03.014. Epub 2021 Mar 29. PMID: 33832820.
  • Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review. Ruess DA, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA. C Pancreas. 2017 Oct;46(9):1225-1233. doi: 10.1097/MPA.0000000000000904. PMID: 28902796.
     
  • Survival outcome and prognostic factors after pancreatoduodenectomy for distal bile duct carcinoma: a retrospective multicenter study. Petrova E, Rückert F, Zach S, Shen Y, Weitz J, Grützmann R, Wittel UA, Makowiec F, Hopt UT, Bronsert P, Kühn F, Rau BM, Izrailov RE, Khatkov IE, Lapshyn H, Bolm L, Bausch D, Keck T, Wellner UF, Seifert G. Langenbecks Arch Surg. 2017 Jun 13. doi: 10.1007/s00423-017-1590-9.  PubMed PMID: 28612115.
     
  • Stereotactic body radiotherapy (SBRT) in recurrent or oligometastatic pancreatic cancer : A toxicity review of simultaneous integrated protection (SIP) versus conventional SBRT. Gkika E, Adebahr S, Kirste S, Schimek-Jasch T, Wiehle R, Claus R, Wittel U, Nestle U, Baltas D, Grosu AL, Brunner TB. Strahlenther Onkol. 2017 Jun;193(6):433-443. doi: 10.1007/s00066-017-1099-8. PMID:  28138949
     
  • The Indications for Laparoscopic Pancreatectomy. Siech M, Strauss P, Huschitt S, Bartsch DK, Wittel U, Keck T.  Dtsch Arztebl Int. 2017 Apr 14;114(15):263-268. doi: 10.3238/arztebl.2017.0263. PubMed PMID: 28468714; PubMed Central PMCID: PMC5424087.
     
  • The predominance of a naive T helper cell subset in the immune response of experimental acute pancreatitis. Schmidt AI, Kühlbrey C, Lauch R, Wolff-Vorbeck G, Chikhladze S, Hopt UT, Wittel UA.  Pancreatology. 2017 Mar - Apr;17(2):209-218. doi: 10.1016/j.pan.2017.02.011. PubMed PMID: 28258935.  
     
  • Pancreatitis After Pancreatoduodenectomy Predicts Clinically Relevant Postoperative Pancreatic Fistula. Kühlbrey CM, Samiei N, Sick O, Makowiec F, Hopt UT, Wittel UA.  J Gastrointest Surg. 2017 Feb;21(2):330-338. doi: 10.1007/s11605-016-3305-x.  PMID:27896656  
     
  • Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry. Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K, Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T; StuDoQ Pancreas study group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV). Int J Colorectal Dis. 2017 Feb;32(2):273-280. doi: 10.1007/s00384-016-2693-4. PubMed PMID: 27815701.    
     
  • Inducing a humoral immune response to pancreatic cancer antigen. Seifert M, Seifert G, Wolff-Vorbeck G, Langenmair E, Hopt UT, Wittel UA. Cell Immunol. 2016 Dec;310:150-155. doi: 10.1016/j.cellimm.2016.09.002. PubMed PMID: 27663207.    
     
  • The prognostic influence of intrapancreatic tumor location on survival after resection of pancreatic ductal adenocarcinoma. Ruess DA, Makowiec F, Chikhladze S, Sick O, Riediger H, Hopt UT, Wittel UA. BMC Surg. 2015 Nov 28;15:123. doi: 10.1186/s12893-015-0110-5. PubMed PMID: 26615588
     
  • Organ-specific monocyte activation in necrotizing pancreatitis in mice. chmidt AI, Seifert GJ, Lauch R, Wolff-Vorbeck G, Chikhladze S, Hopt UT, Wittel UA. J Surg Res. 2015 Aug;197(2):374-81. doi: 10.1016/j.jss.2015.03.075. Epub 2015 Mar 31. PMID: 25982373
     
  • Retrospective analyses of trends in pancreatic surgery: indications, operative techniques, and postoperative outcome of 1,120 pancreatic resections. Wittel UA, Makowiec F, Sick O, Seifert GJ, Keck T, Adam U, Hopt UT.  World J Surg Oncol. 2015 Mar 12;13:102. doi: 10.1186/s12957-015-0525-6. PMID: 25880929
     
  • The chemokine ligand CXCL16 is an indicator of bacterial infection in necrotizing pancreatitis.  Wittel UA, Schmidt AI, Poxleitner PJ, Seifert GJ, Chikhladze S, Puolakkainen P, Hopt UT, Kylänpää L. Pancreatology. 2015 Mar-Apr;15(2):124-30. doi: 10.1016/j.pan.2015.01.004. Epub 2015 Jan 23. PMID: 25661686
     
  • Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceral resection for pancreatic head cancer. Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, Bronsert P, Sick O, Hopt UT, Makowiec F, Riediger H.  J Gastrointest Surg. 2015 Mar;19(3):438-44. doi: 10.1007/s11605-014-2725-8. Epub 2015 Jan 8. PMID: 25567663
     
  • Potentials of plasma NGAL and MIC-1 as biomarker(s) in the diagnosis of lethal pancreatic cancer. Kaur S, Chakraborty S, Baine MJ, Mallya K, Smith LM, Sasson A, Brand R, Guha S, Jain M, Wittel U, Singh SK, Batra SK.  PLoS One. 2013;8(2):e55171. doi: 10.1371/journal.pone.0055171. Epub 2013 Feb 1. PMID: 23383312
     
  • The pathobiological impact of cigarette smoke on pancreatic cancer development (review). Wittel UA, Momi N, Seifert G, Wiech T, Hopt UT, Batra SK. Int J Oncol. 2012 Jul;41(1):5-14. doi: 10.3892/ijo.2012.1414. Epub 2012 Mar 23. Review. PMID: 22446714
     
  • Pathobiological implications of MUC16 expression in pancreatic cancer. Haridas D, Chakraborty S, Ponnusamy MP, Lakshmanan I, Rachagani S, Cruz E, Kumar S, Das S, Lele SM, Anderson JM, Wittel UA, Hollingsworth MA, Batra SK. PLoS One. 2011;6(10):e26839. doi: 10.1371/journal.pone.0026839. Epub 2011 Oct 31. PMID: 22066010
     
  • Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of severity and outcome in acute pancreatitis. Chakraborty S, Kaur S, Muddana V, Sharma N, Wittel UA, Papachristou GI, Whitcomb D, Brand RE, Batra SK. Am J Gastroenterol. 2010 Sep;105(9):2050-9. doi: 10.1038/ajg.2010.23. Epub 2010 Feb 23. PMID: 20179686
     
  • SBRT in pancreatic cancer: what is the therapeutic window? Brunner TB, Nestle U, Grosu AL, Partridge M. Radiother Oncol. 2015 Jan;114(1):109-16. doi: 10.1016/j.radonc.2014.10.015. Epub 2014 Nov 25. Review. PMID: 25466369
     
  • Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review. Bittner MI, Grosu AL, Brunner TB. Radiother Oncol. 2015 Jan;114(1):117-21. doi: 10.1016/j.radonc.2014.11.043. Epub 2014 Dec 11. Review. PMID: 25497876
     
  • Endobiliary Stent Position Changes during External-beam Radiotherapy. Chu KY, Eccles CL, Brunner TB. J Med Imaging Radiat Sci. 2015 Mar;46(1):57-64. PMID: 26090069
     
  • IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Lunardi S, Jamieson NB, Lim SY, Griffiths KL, Carvalho-Gaspar M, Al-Assar O, Yameen S, Carter RC, McKay CJ, Spoletini G, D'Ugo S, Silva MA, Sansom OJ, Janssen KP, Muschel RJ, Brunner TB. Oncotarget. 2014 Nov 30;5(22):11064-80. PMID: 25415223
     
  • Neoadjuvant therapy for potentially resectable pancreatic cancer: an emerging paradigm? Brunner TB. Curr Oncol Rep. 2013 Apr;15(2):162-9. doi: 10.1007/s11912-012-0291-3. Review. PMID: 23325567

Kontakt:

PD Dr. med. Dietrich Ruess
Geschäftsführender Oberarzt
Leitung Bereich Pankreaschirurgie und Sarkome
dietrich.ruess@uniklinik-freiburg.de

Dr. med. Sophia Chikhladze
Geschäftsführende Oberärztin
Leitung Bereich Sarkome und Pankreaschirurgie
sophia.chikhladze@uniklinik-freiburg.de