Klinik für Psychiatrie und Psychotherapie

Research focus

The current research activities of the work group of Prof. Schramm focuses on the evaluation of specific psychotherapeutic approaches for the treatment of acute episodic and chronic depressive disorders. Recent studies are based on the “Cognitive Behavioral Analysis System of Psychotherapy” (CBASP) in comparison to other psychotherapeutic or pharmacologic treatments. CBASP therapy had been developed by McCullough and is the only therapeutic strategy specifically developed for chronic depression so far. We investigate the acute and longterm effects of inpatient and outpatient CBASP programs. Further fields of interest relate a) to the investigation of corresponding changes in neural functions by fMRI; b) to the evaluation of a group maintenance treatment for recurrently depressed patients (Nature- and animal assisted Mindfulness Therapy) and c) Work-focused Interpersonal Psychotherapy (W-IPT) for patients with a depression related to work stress d) Psychotherapy approaches for the treatment of late life depression, e) evaluation of an online coach for significant others of depressed patients, and e) Modular psychotherapy for comorbid depression.

Research projects

*) Das interaktive Online-Programm "Familiencoach Depression" ist nun fertig und kann kostenlos genutzt werden. [Erfahren Sie mehr ...]

Selected peer-reviewed publications

• Schramm E, Elsaesser M, Jenkner C, et al (2024) Algorithm-based modular psychotherapy vs. cognitive-behavioral therapy for patients with depression, psychiatric comorbidities and early trauma: a proof-of-concept randomized controlled trial. World Psychiatry;23:257-266
• Goerigk S, Elsaesser M, Reinhard MA,… Schramm E (2024) Clusters of Adverse Childhood Experiences Predict the Efficacy of Specific versus Nonspecific Psychotherapy in Early-Onset Chronic Depression. The Lancet Psychiatry; 11:709–19
• Schumacher L, Klein JP, Hautzinger M… Schramm E, Kriston L  (2024) Predicting psychotherapeutic treatment outcome for chronic depression with personspecific symptom networks. World Psychiatry; 23(3):411-420.
• Elsaesser M, Feige B, Kriston L,… Schramm E (2024) Longitudinal clusters of long-term trajectories in patients with early-onset chronic depression: Two years of naturalistic follow-up after extensive psychological treatment. Psychotherapy & Psychosomatics. 93(1):65-74
• Schumacher L, Klein JP, Elsaesser M, …Schramm E, Kriston L (2023) Implications of the Network Theory for the Treatment of Mental Disorders: A Secondary Analysis of a Randomized Clinical Trial. JAMA Psychiatry. 80(11):1160-1168
• Dafsari FS, Bewernick BH, Boehringer S, … SchrammE,.. (2023) Cognitive behavioral therapy for late life depression (CBTlate): results of a multicenter, randomized, observer-blinded, controlled trial. Psychother Psychosom 2023, 1-13.
• Schramm E, Breuninger C, Wohlfarth R, et al (2022) Effectiveness of Nature- and Animal Assisted Mindfulness for Relapse Prevention in Depressed Patients With a History of Childhood Maltreatment. Front. Psychiatry 13:899318.doi: 10.3389/fpsyt.2022.899318
• Schramm E, Elsaesser M, Guidi J. (2022) The role of psychological interventions in the maintenance treatment of depression. Psychother Psychosom 2022 DOI: 10.1159/000522014
• Schramm E, Klein D, Elsaesser M, et al (2020). Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications. Lancet Psychiatry, 7:801-12.
• Schramm E, Mack S, Thiel N, et al (2020) Interpersonal Psychotherapy vs. Treatment as Usual for Major Depression Related to Work Stress: A Pilot Randomized Controlled Study. Front. Psychiatry, 11:193.doi: 10.3389/fpsyt.2020.00193

Vollständige Publikationsliste

Funding

• Deutsche Forschungsgemeinschaft (DFG)
• Bundesministerium für Bildung und Forschung (BMBF)
• Ministerium für Wissenschaft, Forschung und Kunst
• Lundbeck
• Stiftung zur Förderung der Erforschung der Zivilisationserkrankungen
• AOK-Bundesverband
• Programm Klinische Studien, Universität Freiburg
• Innovationsfonds Projektträger DRL
• Stiftung für Seelische Gesundheit