Klinik für Neurologie und Neurophysiologie

Selected Publications

• Aires V, Ziegler-Waldkirch S, Friesen M, Reichardt W, Erny D, Loreth D, Harborne A, Kretz O, von Elverfeldt D, Meyer-Luehmann M. Seed-induced Aβ deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer's disease. Front Cell Neurosci. 2022 Aug 8;16:862918. doi: 10.3389/fncel.2022.862918. PMID: 36003141; PMCID: PMC9393256.
• Ziegler-Waldkirch S, Friesen M, Loreth D, Sauer JF, Kemna S, Hilse A, Erny D, Helm C, D Errico P, Prinz M, Bartos M, Meyer-Luehmann M. Seed-induced Aβ deposition alters neuronal function and impairs olfaction in a mouse model of Alzheimer's disease. Mol Psychiatry. 2022 Jul 22. doi: 10.1038/s41380-022-01686-5. Epub ahead of print. PMID: 35869271.
• Friesen M, Ziegler-Waldkirch S, Egenolf M, d'Errico P, Helm C, Mezö C, Dokalis N, Erny D, Katzmarski N, Coelho R, Loreth D, Prinz M, Meyer-Luehmann M. Distinct Aβ pathology in the olfactory bulb and olfactory deficits in a mouse model of Aβ and α-syn co-pathology. Brain Pathol. 2022 May;32(3):e13032. doi: 10.1111/bpa.13032. Epub 2021 Oct 29. PMID: 34713522; PMCID: PMC9048518.
• d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M. Microglia contribute to the propagation of Aβ into unaffected brain tissue. Nat Neurosci. 2022 Jan;25(1):20-25. doi: 10.1038/s41593-021-00951-0. Epub 2021 Nov 22. PMID: 34811521; PMCID: PMC8737330
• d'Errico P, Meyer-Luehmann M. Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer's Disease. Front Aging Neurosci. 2020 Aug 27;12:265. doi: 10.3389/fnagi.2020.00265. PMID: 33061903; PMCID: PMC7481386.
• Katzmarski N, Ziegler-Waldkirch S, Scheffler N, Witt C, Abou-Ajram C, Nuscher B, Prinz M, Haass C, Meyer-Luehmann M. Aβ oligomers trigger and accelerate Aβ seeding. Brain Pathol. 2020 Jan;30(1):36-45. doi: 10.1111/bpa.12734. Epub 2019 Jun 5. PMID: 31099449; PMCID: PMC6916291.
• Friesen M, Meyer-Luehmann M. Aβ Seeding as a Tool to Study Cerebral Amyloidosis and Associated Pathology. Front Mol Neurosci. 2019 Oct 2;12:233. doi: 10.3389/fnmol.2019.00233. PMID: 31632238; PMCID: PMC6783493.
• Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7. PMID: 30617257; PMCID: PMC6417433.
• Ziegler-Waldkirch S, Meyer-Luehmann M. The Role of Glial Cells and Synapse Loss in Mouse Models of Alzheimer's Disease. Front Cell Neurosci. 2018 Dec 11;12:473. doi: 10.3389/fncel.2018.00473. PMID: 30618627; PMCID: PMC6297249.
• Ziegler-Waldkirch S, Marksteiner K, Stoll J, d'Errico P, Friesen M, Eiler D, Neudel L, Sturn V, Opper I, Datta M, Prinz M, Meyer-Luehmann M. Environmental enrichment reverses Aβ pathology during pregnancy in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2018 May 31;6(1):44. doi: 10.1186/s40478-018-0549-6. PMID: 29855361; PMCID: PMC5984325
• Datta, M, Staszewski, O, Raschi, E, Frosch, M, Hagemeyer, N, Tay, TL, Kreutzfeldt M, Merkler D, Ziegler-Waldkirch S, Matthias P, Meyer-Luehmann M, Prinz, M. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. 2018 Mar 20;48(3):514-529.e6. doi: 10.1016/j.immuni.2018.02.016
• Ziegler-Waldkirch S, d′Errico P, Sauer J, Erny D, Savanthrapadian S, Loreth D, Katzmarski N, Blank T, Bartos M, Prinz M, Meyer-Luehmann M. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer’s disease. EMBO J. 2018 Jan 17;37(2):167-182. doi: 10.15252/embj.201797021.
• Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nat Med. 2015 Jul;21(7):802-7. doi: 10.1038/nm.3885.
• Derecki NC, Katzmarski N, Kipnis J, Meyer-Luehmann M. Microglia as a critical player in both developmental and late-life CNS pathologies. Acta Neuropathol. 2014 Sep;128(3):333-45. doi: 10.1007/s00401-014-1321-z.
• Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M. Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Mol Psychiatry. 2014 Sep 24 doi: 10.1038/mp.2013.122.
• McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathol. 2013 Aug;126(2):179-88. doi: 10.1007/s00401-013-1137-2.
• Liebscher S, Meyer-Luehmann M. A Peephole into the Brain: Neuropathological Features of Alzheimer's Disease Revealed by in vivo Two-Photon Imaging. Front Psychiatry. 2012 Apr 2;3:26. doi: 10.3389/fpsyt.2012.00026.
• Meyer-Luehmann M, Mora JR, Mielke M, Spires-Jones TL, de Calignon A, von Andrian UH, Hyman BT. T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice. Mol Neurodegener. 2011 Mar 9;6:22. doi: 10.1186/1750-1326-6-22.
• Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. J Neurosci. 2009 Oct 7;29(40):12636-40. doi: 10.1523/JNEUROSCI.1948-09.2009.
• Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. doi: 10.1073/pnas.0811698106.
• Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008 Feb 7;451(7179):720-4. doi: 10.1038/nature06616.
• Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006 Sep 22;313(5794):1781-4.
• Meyer-Luehmann M, Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M. Extracellular amyloid formation and associated pathology in neural grafts. Nat Neurosci. 2003 Apr;6(4):370-7.

Further publications please see PubMed.