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Hyperpolarization

Publications

Dr. Andreas Schmidt's Google Scholer Profile

2024

  • Petersen, S.; Nagel, L.; Groß, P.; Willing, R.; Heß, L.; Mitschke, J.; Klemm, N.; Treiber, J.; Müller, C.; Knecht, S.; Schwartz, I.; Weigt, M.; Bock, M.; Elverfeldt, D. von; Zaitsev, M.; Chekmenev, E.; Hövener, J.-B.; Martins, A.; Schilling, F.; Reinheckel, T.; Schmidt, A. In Vivo Molecular Imaging of Breast Cancer Metabolic Heterogeneity Using [1-13C]Pyruvate-D3 Hyperpolarized By Reversible Exchange With Parahydrogen. 2024. https://doi.org/10.26434/chemrxiv-2024-qk0fh.
  • Adelabu, I.; Nantogma, S.; Fleischer, S.; Abdulmojeed, M.; de Maissin, H.; Schmidt, A. B.; Lehmkuhl, S.; Rosen, M. S.; Appelt, S.; Theis, T.; Qian, C.; Chekmenev, E. Y. Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing. Angew. Chem. 2024, 136 (37), e202406551. https://doi.org/10.1002/ange.202406551.
  • Schmidt, A. B.; Chekmenev, E.; de Maissin, H.; Groß, P. R.; Petersen, S.; Nagel, L.; Schilling, F.; Schwartz, I.; Reinheckel, T.; Hövener, J.-B.; Knecht, S. Signal Amplification By Reversible Exchange and Its Translation to Hyperpolarized Magnetic Resonance Imaging in Biomedicine. Anal. Sens. 2024, n/a (n/a), e202400039. https://doi.org/10.1002/anse.202400039.
  • Nantogma, S.; Chowdhury, M. R. H.; Kabir, M. S. H.; Adelabu, I.; Joshi, S. M.; Samoilenko, A.; de Maissin, H.; Schmidt, A. B.; Nikolaou, P.; Chekmenev, Y. A.; Salnikov, O. G.; Chukanov, N. V.; Koptyug, I. V.; Goodson, B. M.; Chekmenev, E. Y. MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition. Anal. Chem. 2024, 96 (10), 4171–4179. https://doi.org/10.1021/acs.analchem.3c05233.
  • Nantogma, S.; de Maissin, H.; Adelabu, I.; Abdurraheem, A.; Nelson, C.; Chukanov, N. V.; Salnikov, O. G.; Koptyug, I. V.; Lehmkuhl, S.; Schmidt, A. B.; Appelt, S.; Theis, T.; Chekmenev, E. Y. Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-13C]Pyruvate. ACS Sens. 2024, 9 (2), 770–780. https://doi.org/10.1021/acssensors.3c02075.
  • Awenius, M.; Abeln, H.; Müller, M.; Franke, V. L.; Rincon, G.; Glowa, C.; Schmitt, M.; Bangert, R.; Ludwig, D.; Schmidt, A. B.; Kuder, T. A.; Ladd, M. E.; Bachert, P.; Biegger, P.; Korzowski, A. Three-Dimensional Radial Echo-Planar Spectroscopic Imaging for Hyperpolarized C MRSI in Vivo. Magn. Reson. Med. 2024, n/a (n/a). https://doi.org/10.1002/mrm.30258.

2023

  • Chaumeil, M. M.; Bankson, J. A.; Brindle, K. M.; Epstein, S.; Gallagher, F. A.; Grashei, M.; Guglielmetti, C.; Kaggie, J. D.; Keshari, K. R.; Knecht, S.; Laustsen, C.; Schmidt, A. B.; Vigneron, D.; Yen, Y.-F.; Schilling, F. New Horizons in Hyperpolarized 13C MRI. Mol. Imaging Biol. 2023, 26 (2), 222–232. https://doi.org/10.1007/s11307-023-01888-5.
  • Hune, T. L. K.; Mamone, S.; Schmidt, A. B.; Mahú, I.; D’Apolito, N.; Wiedermann, D.; Brüning, J.; Glöggler, S. Hyperpolarized Multi-Organ Spectroscopy of Liver and Brain Using 1-13C-Pyruvate Enhanced via Parahydrogen. Appl. Magn. Reson. 2023. https://doi.org/10.1007/s00723-023-01578-z.
  • de Maissin, H.; Groß, P. R.; Mohiuddin, O.; Weigt, M.; Nagel, L.; Herzog, M.; Wang, Z.; Willing, R.; Reichardt, W.; Pichotka, M.; Heß, L.; Reinheckel, T.; Jessen, H. J.; Zeiser, R.; Bock, M.; von Elverfeldt, D.; Zaitsev, M.; Korchak, S.; Glöggler, S.; Hövener, J.-B.; Chekmenev, E. Y.; Schilling, F.; Knecht, S.; Schmidt, A. B. In vivo-Stoffwechselbildgebung mit [1-13C]Pyruvat-d3, hyperpolarisiert durch reversiblen Austausch mit Parawasserstoff**. Angew. Chem. 2023, 135 (36), e202306654. https://doi.org/10.1002/ange.202306654.
  • Saul, P.; Schröder, L.; Schmidt, A. B.; Hövener, J.-B. Nanomaterials for Hyperpolarized Nuclear Magnetic Resonance and Magnetic Resonance Imaging. WIREs Nanomedicine Nanobiotechnology 2023, 15 (4), e1879. https://doi.org/10.1002/wnan.1879.
  • Schmidt, A. B.; Eills, J.; Dagys, L.; Gierse, M.; Keim, M.; Lucas, S.; Bock, M.; Schwartz, I.; Zaitsev, M.; Chekmenev, E. Y.; Knecht, S. Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT. J. Phys. Chem. Lett. 2023, 14 (23), 5305–5309. https://doi.org/10.1021/acs.jpclett.3c00707.
  • de Maissin, H.; Groß, P. R.; Mohiuddin, O.; Weigt, M.; Nagel, L.; Herzog, M.; Wang, Z.; Willing, R.; Reichardt, W.; Pichotka, M.; Heß, L.; Reinheckel, T.; Jessen, H. J.; Zeiser, R.; Bock, M.; von Elverfeldt, D.; Zaitsev, M.; Korchak, S.; Glöggler, S.; Hövener, J.-B.; Chekmenev, E. Y.; Schilling, F.; Knecht, S.; Schmidt, A. B. In Vivo Metabolic Imaging of [1-13C]Pyruvate-D3 Hyperpolarized By Reversible Exchange With Parahydrogen**. Angew. Chem. Int. Ed. 2023, 62 (36), e202306654. https://doi.org/10.1002/anie.202306654.
  • Chowdhury, R.; Mueller, C. A.; Smith, L.; Gong, F.; Papoutsaki, M.-V.; Rogers, H.; Syer, T.; Singh, S.; Brembilla, G.; Retter, A.; Bullock, M.; Caselton, L.; Mathew, M.; Dineen, E.; Parry, T.; Hennig, J.; von Elverfeldt, D.; Schmidt, A. B.; Hövener, J.-B.; Emberton, M.; Atkinson, D.; Bainbridge, A.; Gadian, D. G.; Punwani, S. Quantification of Prostate Cancer Metabolism Using 3D Multiecho bSSFP and Hyperpolarized [1-13C] Pyruvate: Metabolism Differs Between Tumors of the Same Gleason Grade. J. Magn. Reson. Imaging 2023, 57 (6), 1865–1875. https://doi.org/10.1002/jmri.28467.
  • Schmidt, A. B.; Adelabu, I.; Nelson, C.; Nantogma, S.; Kiselev, V. G.; Zaitsev, M.; Abdurraheem, A.; de Maissin, H.; Rosen, M. S.; Lehmkuhl, S.; Appelt, S.; Theis, T.; Chekmenev, E. Y. 13C Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions. J. Am. Chem. Soc. 2023, 145 (20), 11121–11129. https://doi.org/10.1021/jacs.3c00776.
  • Nelson, C.; Schmidt, A. B.; Adelabu, I.; Nantogma, S.; Kiselev, V. G.; Abdurraheem, A.; de Maissin, H.; Lehmkuhl, S.; Appelt, S.; Theis, T.; Chekmenev, E. Y. Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation. Angew. Chem. Int. Ed. 2023, 62 (5), e202215678. https://doi.org/10.1002/anie.202215678.
  • Hune, T.; Mamone, S.; Schroeder, H.; Jagtap, A. P.; Sternkopf, S.; Stevanato, G.; Korchak, S.; Fokken, C.; Müller, C. A.; Schmidt, A. B.; Becker, D.; Glöggler, S. Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-13C-Pyruvate-D3. ChemPhysChem 2023, 24 (2), e202200615. https://doi.org/10.1002/cphc.202200615.

2022

  • Schmidt, A. B.; de Maissin, H.; Adelabu, I.; Nantogma, S.; Ettedgui, J.; TomHon, P.; Goodson, B. M.; Theis, T.; Chekmenev, E. Y. Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange. ACS Sens. 2022, 7 (11), 3430–3439. https://doi.org/10.1021/acssensors.2c01715.
  • Schmidt, A. B.; Zimmermann, M.; Berner, S.; de Maissin, H.; Müller, C. A.; Ivantaev, V.; Hennig, J.; Elverfeldt, D. v; Hövener, J.-B. Quasi-Continuous Production of Highly Hyperpolarized Carbon-13 Contrast Agents Every 15 Seconds within an MRI System. Commun. Chem. 2022, 5 (1), 1–7. https://doi.org/10.1038/s42004-022-00634-2.
  • Pravdivtsev, A. N.; Hövener, J.-B.; Schmidt, A. B. Frequency-Selective Manipulations of Spins Allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly-Coupled Spin Systems. ChemPhysChem 2022, 23 (3), e202100721. https://doi.org/10.1002/cphc.202100721.
  • Schmidt, A. B.; Bowers, C. R.; Buckenmaier, K.; Chekmenev, E. Y.; de Maissin, H.; Eills, J.; Ellermann, F.; Glöggler, S.; Gordon, J. W.; Knecht, S.; Koptyug, I. V.; Kuhn, J.; Pravdivtsev, A. N.; Reineri, F.; Theis, T.; Them, K.; Hövener, J.-B. Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques. Anal. Chem. 2022, 94 (1), 479–502. https://doi.org/10.1021/acs.analchem.1c04863.

2021

  • Schmidt, A. B.; Brahms, A.; Ellermann, F.; Knecht, S.; Berner, S.; Hennig, J.; Elverfeldt, D. von; Herges, R.; Hövener, J.-B.; Pravdivtsev, A. Selective Excitation of Hydrogen Doubles the Yield and Improves the Robustness of Parahydrogen-Induced Polarization of Low-γ Nuclei. Phys. Chem. Chem. Phys. 2021, No. 23, 26645–26652. https://doi.org/10.1039/D1CP04153C.
  • Mamone, S.; Schmidt, A. B.; Schwaderlapp, N.; Lange, T.; von Elverfeldt, D.; Hennig, J.; Glöggler, S. Localized Singlet-Filtered MRS in Vivo. NMR Biomed. 2020, e4400. https://doi.org/10.1002/nbm.4400.
  • Berner, S.; Schmidt, A. B.; Ellermann, F.; Korchak, S.; Chekmenev, E. Y.; Glöggler, S.; Elverfeldt, D. von; Hennig, J.; Hövener, J.-B. High Field Parahydrogen Induced Polarization of Succinate and Phospholactate. Phys. Chem. Chem. Phys. 2021, 23 (3), 2320–2330. https://doi.org/10.1039/D0CP06281B.

Before 2021

  • Joalland, B.; Schmidt, A. B.; Kabir, M. S. H.; Chukanov, N. V.; Kovtunov, K. V.; Koptyug, I. V.; Hennig, J.; Hövener, J.-B.; Chekmenev, E. Y. Pulse-Programmable Magnetic Field Sweeping of Parahydrogen-Induced Polarization by Side Arm Hydrogenation. Anal. Chem. 2020, 92 (1), 1340–1345. https://doi.org/10.1021/acs.analchem.9b04501.
  • Schmidt, A. B.; Wörner, J.; Pravdivtsev, A.; Knecht, S.; Scherer, H.; Weber, S.; Hennig, J.; von Elverfeldt, D.; Hövener, J.-B. Lifetime of Parahydrogen in Aqueous Solutions and Human Blood. ChemPhysChem 2019, 20 (19), 2408–2412. https://doi.org/10.1002/cphc.201900670.
  • Berner, S.; Schmidt, A. B.; Zimmermann, M.; Pravdivtsev, A. N.; Glöggler, S.; Hennig, J.; von Elverfeldt, D.; Hövener, J.-B. SAMBADENA Hyperpolarization of 13C-Succinate in an MRI: Singlet-Triplet Mixing Causes Polarization Loss. ChemistryOpen 2019, 8 (6), 728–736. https://doi.org/10.1002/open.201900139.
  • Skinner, J. G.; Menichetti, L.; Flori, A.; Dost, A.; Schmidt, A. B.; Plaumann, M.; Gallagher, F. A.; Hövener, J.-B. Metabolic and Molecular Imaging with Hyperpolarised Tracers. Mol. Imaging Biol. 2018, 20 (6), 902–918. https://doi.org/10.1007/s11307-018-1265-0.
  • Schmidt, A. B.; Berner, S.; Braig, M.; Zimmermann, M.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. In Vivo 13C-MRI Using SAMBADENA. PLOS ONE 2018, 13 (7), e0200141. https://doi.org/10.1371/journal.pone.0200141.
  • Schmidt, A. B.; Berner, S.; Schimpf, W.; Müller, C.; Lickert, T.; Schwaderlapp, N.; Knecht, S.; Skinner, J. G.; Dost, A.; Rovedo, P.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. Liquid-State Carbon-13 Hyperpolarization Generated in an MRI System for Fast Imaging. Nat. Commun. 2017, 8, 14535. https://doi.org/10.1038/ncomms14535.
  • Schmidt, A. B.; Andrews, D. L.; Rohrbach, A.; Gohn-Kreuz, C.; Shatokhin, V. N.; Kiselev, V. G.; Hennig, J.; von Elverfeldt, D.; Hövener, J.-B. Do Twisted Laser Beams Evoke Nuclear Hyperpolarization? J. Magn. Reson. 2016, 268, 58–67. https://doi.org/10.1016/j.jmr.2016.04.015.
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