Department of Radiology - Medical Physics

Short Bio

Dr. Andreas B. Schmidt leads the Hyperpolarization Group at the University Medical Center Freiburg and coordinates the HYPERBOLIC project within the German Cancer Consortium (DKTK). He is a Junior Fellow of the ISMRM under mentorship of Dan Vigneron. He studied Physics in Freiburg and Madrid, earned his PhD under Jürgen Hennig and Jan-Bernd Hövener and completed postdoctoral research with Eduard Chekmenev at Wayne State University.

Dr. Schmidt’s research focuses on parahydrogen-based polarization methods, metabolic imaging, and their biomedical translation.

Research (Group: Hyperpolarization)

Selected Publications (Complete Google Scholar Profile):

(1)        Schmidt, A. B.; Adelabu, I.; Nelson, C.; Nantogma, S.; Kiselev, V. G.; Zaitsev, M.; Abdurraheem, A.; de Maissin, H.; Rosen, M. S.; Lehmkuhl, S.; Appelt, S.; Theis, T.; Chekmenev, E. Y. 13C Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions. J. Am. Chem. Soc. 2023, 145 (20), 11121–11129. DOI: 10.1021/jacs.3c00776.

(2)        Nelson, C.; Schmidt, A. B.*; Adelabu, I.; Nantogma, S.; Kiselev, V. G.; Abdurraheem, A.; de Maissin, H.; Lehmkuhl, S.; Appelt, S.; Theis, T.; Chekmenev, E. Y. Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation. Angew. Chem. Int. Ed. 2023, 62 (5), e202215678. DOI: 10.1002/anie.202215678.
*shared first author

(3)        Schmidt, A. B.; de Maissin, H.; Adelabu, I.; Nantogma, S.; Ettedgui, J.; TomHon, P.; Goodson, B. M.; Theis, T.; Chekmenev, E. Y. Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange. ACS Sens. 2022, 7 (11), 3430–3439. DOI: 10.1021/acssensors.2c01715.

(4)        Schmidt, A. B.; Zimmermann, M.; Berner, S.; de Maissin, H.; Müller, C. A.; Ivantaev, V.; Hennig, J.; Elverfeldt, D. v; Hövener, J.-B. Quasi-Continuous Production of Highly Hyperpolarized Carbon-13 Contrast Agents Every 15 Seconds within an MRI System. Commun. Chem. 2022, 5 (1), 1–7. DOI: 10.1038/s42004-022-00634-2.

(5)        Schmidt, A. B.; Brahms, A.; Ellermann, F.; Knecht, S.; Berner, S.; Hennig, J.; Elverfeldt, D. von; Herges, R.; Hövener, J.-B.; Pravdivtsev, A. Selective Excitation of Hydrogen Doubles the Yield and Improves the Robustness of Parahydrogen-Induced Polarization of Low-γ Nuclei. Phys. Chem. Chem. Phys. 2021, No. 23, 26645–26652. DOI: 10.1039/D1CP04153C.

(6)        Schmidt, A. B.; Berner, S.; Schimpf, W.; Müller, C.; Lickert, T.; Schwaderlapp, N.; Knecht, S.; Skinner, J. G.; Dost, A.; Rovedo, P.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. Liquid-State Carbon-13 Hyperpolarization Generated in an MRI System for Fast Imaging. Nat. Commun. 2017, 8, 14535. DOI: 10.1038/ncomms14535.

(7)        Schmidt, A. B.; Berner, S.; Braig, M.; Zimmermann, M.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. In Vivo 13C-MRI Using SAMBADENA. PLOS ONE 2018, 13 (7), e0200141. DOI: 10.1371/journal.pone.0200141.

(8)        Mamone, S.; Schmidt, A. B.; Schwaderlapp, N.; Lange, T.; von Elverfeldt, D.; Hennig, J.; Glöggler, S. Localized Singlet-Filtered MRS in Vivo. NMR Biomed. 2020, e4400. DOI: 10.1002/nbm.4400.

(9)        Pravdivtsev, A. N.; Hövener, J.-B.; Schmidt, A. B. Frequency-Selective Manipulations of Spins Allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly-Coupled Spin Systems. ChemPhysChem 2022, 23 (3), e202100721. DOI: 10.1002/cphc.202100721.

(10)      de Maissin, H.; Groß, P. R.; Mohiuddin, O.; Weigt, M.; Nagel, L.; Herzog, M.; Wang, Z.; Willing, R.; Reichardt, W.; Pichotka, M.; Heß, L.; Reinheckel, T.; Jessen, H. J.; Zeiser, R.; Bock, M.; von Elverfeldt, D.; Zaitsev, M.; Korchak, S.; Glöggler, S.; Hövener, J.-B.; Chekmenev, E. Y.; Schilling, F.; Knecht, S.; Schmidt, A. B. In Vivo Metabolic Imaging of [1-13C]Pyruvate-D3 Hyperpolarized By Reversible Exchange With Parahydrogen. Angew. Chem. Int. Ed. 2023, 62 (36), e202306654. DOI: 10.1002/anie.202306654.

PhD thesis:

“Liquid-State Nuclear Hyperpolarization Without a Polarizer – Synthesis Amid the Magnet Bore Allows a Dramatically Enhanced Nuclear Alignment” (25/02/2020, Department of Physics and Mathematics, University of Freiburg)

Diploma thesis:

“Nuclear hyperpolarization using twisted light beams at low magnetic fields” (03/11/2014, Department of Physics and Mathematics, University of Freiburg)

Research interests include

• Nuclear Hyperpolarization
• Singlet States and Singlet-Filtered (SiFi) Spectroscopy
• Radio Amplification by Stimulated Emission of Radiation (RASER)
• Low Field MRI and NMR
• Metabolic and Molecular MRI