Klinik für Anästhesiologie und Intensivmedizin

Studium, Promotion und Habilitation

Klinische Qualifikation

Lehre

Wissenschaftliche Schwerpunkte

Preise

Mitgliedschaften

• Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin  (wissenschaftliche Arbeitskreise Neuroanästhesie und Thoraxanästhesie)
• Berufsverband Deutscher Anästhesisten
• European Society of Anesthesiology
• European Association of Cardiothoracic Anaesthesiologists

Gutachter bei

• Anesthesiology, Clinical Drug Investigation
• Expert Opinion in Pharmacotherapy, Der Anaesthesist

Originalarbeiten

1995

Benzing A., Bräutigam P., Geiger KK., Loop T., Beyer U., Moser E.: Inhaled nitric oxide reduces pulmonary transvascular albumin flux in patients with acute lung injury. Anesthesiology 1995; 83:1153-1161 (IF: 3.501)

1996

Benzing A., Loop T., Mols G., Geiger KK.: Effect of inhaled nitric oxide on venous admixture depends on cardiac output in patients with acute lung injury and acute respiratory distress syndrome. Acta Anaesthesiol Scand 1996;40:466-474 (IF: 1.68)

1999

Benzing A., Loop T., Mols G., Geiger KK.: Unintended inhalation of nitric oxide by contamination of compressed air: physiologic effects and interference with intended nitric oxide inhalation in acute lung injury. Anesthesiology 1999; 91:945-950 (IF: 3.501)

Mols G., Brandes I., Kessler V., Lichtwarck-Aschoff M., Loop T., Geiger K., Guttmann J.: Volume-dependent compliance in ARDS: proposal of a new diagnostic concept. Intensive Care Med 1999; 25:1084-1091 (IF: 2.971)

2000

Loop T., Priebe HJ.: Recovery after anesthesia with remifentanil combined with propofol, desflurane, or sevoflurane for otorhinolaryngeal surgery. Anesth Analg 2000; 91:123-129 (IF: 2.210)

von der Esche U., Ayoub M., Pfannes SD., Mueller MR., Huber M., Wiesmueller KH., Loop T., Humar M., Fischbach KF., Strunkelnberg M., Hoffmann P., Bessler WG., Mittenbuehler K.: Immunostimulation by bacterial components: I. Activation of macrophages and enhancement of genetic immunization by the lipopeptide P3CSK4. Int J Immunopharmacol 2000; 22:1093-1102 (IF : 2.203)

2001

Hoetzel A., Vagts DA., Loop T., Humar M., Bauer M., Pahl HL., Geiger KK., Pannen BHJ.: Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat. Hepatology 2001; 33:925-937 (IF: 9.503)

Pannen BHJ., Schroll S., Loop T., Bauer M., Hoetzel A., Geiger KK.: Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1. Am J Physiol Heart Circ Physiol 2001; 281:H1075-1084 (IF: 3.658)

2002

Loop T., Liu Z., Humar M., Hoetzel A., Benzing A., Pahl HL., Geiger KK., Pannen BH.: Thiopental inhibits the activation of nuclear factor κB. Anesthesiology 2002; 96:1202-1213 (IF: 3.501)

Loop T., Priebe HJ.: A prospective, randomised cost analysis of anesthesia with remifentanil combined with propofol, desflurane or sevoflurane for otorhinolaryngeal surgery. Acta Anaesthesiol Scand 2002; 46:1251-60 (IF: 1.680)

Mueller MR., Wiesmueller KH., Jung G., Loop T., Humar M., Pfannes SD., Bessler WG., Mittenbuehler K.: Lipopeptide adjuvants: monitoring and comparison of P3CSK4- and LPS-induced gene transcription. Int Immunopharmacol 2002; 2:1065-1077 (IF : 2.203)

Hoetzel A., Geiger S., Loop T., Welle A., Schmidt R., Pahl HL., Geiger KK., Pannen BHJ.: Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat. Anesthesiology 2002; 97:1318-21 (IF: 3.501)

2003

Loop T., Humar M., Pischke S., Hoetzel A., Schmidt R., Pahl HL., Geiger KK., Pannen BHJ.: Thiopental inhibits tumor necrosis factor α-induced activation of nuclear factor κB through suppression of κB kinase activity. Anesthesiology 2003; 99:360-367 (IF:3.501)

Morse D., Pischke SE., Zhou Z., Davis RJ., Flavell RA., Loop T., Otterbein SL., Otterbein LE., Choi AM.: Suppression of inflammatory cytokine production by carbon monoxide involves the c-Jun NH2 terminal kinase (JNK) pathway and activator protein-1 (AP-1). J Biol Chem 2003; 278:36993-36998 (IF: 6.482)

2004

Humar M., Pischke SE., Loop T., Hoetzel A., Schmidt R., Klaas C., Pahl HL., Geiger KK., Pannen BH.: Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol 2004; 65:350-361 (IF: 5.650)

Schmidt R., Hoetzel A., Baechle T., Loop T., Humar M., Bauer M., Pahl H.L., Geiger K.K., Pannen B.H.J.: Isoflurane pretreatment lowers portal venous resitance by increasing hepatic heme oxygenase activity in the rat liver in vivo. J Hepatol 2004; 41:706-713 (IF: 5.283)

Humar M., Andriopoulos N., Pischke SE., Loop T., Schmidt R., Hoetzel A., Roesslein M., Pahl HL., Geiger KK., Pannen BH.: Inhibition of AP-1 by barbiturates is mediated by differential effects on MAP-kinases and the small G proteins Ras and Rac-1. J Pharmacol Exp Ther 2004; 311:1232-40 (IF: 4.337)

Loop T., Scheiermann P., Doviakue D., Musshoff F., Humar M., Roesslein M., Hoetzel A., Schmidt R., Madea B., Geiger KK., Pahl HL., Pannen BH.: Sevoflurane inhibits phorbol-myristate-acetate-induced Activator Protein-1 activation in human T lymphocytes in vitro: Potential role of the p38-stress kinase pathway. Anesthesiology 2004; 101:710-721 (IF: 3.501)

Loop T., Bross T., Humar M., Hoetzel A., Schmidt R., Pahl HL., Geiger KK., Pannen BH.: Dobutamine inhibits phorbol-myristate-acetate (PMA)-induced activation of nuclear factor κB in human T lymphocytes in vitro. Anesth Analg 2004; 99:1508-1515 (IF: 2.210)

2005

Loop T., Doviakue D., Frick M., Roesslein M., Egger L., Musshoff F., Humar M., Hoetzel A., Schmidt R., Borner C., Geiger KK., Pahl HL., Pannen BH.: Sevoflurane induces mitochondrial- and caspase-3-dependent apoptosis in human T lymphocytes in vitro. Anesthesiology 2005; 102:1147-1157 (IF: 3.501)

2006

Hoetzel A., Leitz D., Schmidt R., Tritschler E., Bauer I., Loop T., Humar M., Geiger KK., Pannen BH.: Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology 2006; 104:101-109 (IF: 3.501)

Schmidt R., Baechle T., Hoetzel A., Loop T., Humar M., Roesslein M, Geiger KK., Pannen BH.: Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. Crit Care Med 2006 34:815-822 (IF: 5.07)

2007

Schmal H., Niemeyer P, Roesslein M., Hartl D., Loop T, Südkamp N., Stark G., Mehlhorn A.: Comparison of cellular functionality of human mesenchymal stromal cells and PBMC. Cytotherapy 2007; 9:69-79 (IF: 2.165)

Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK, Pannen BH Isoflurane pretreatment protects rat livers from ischemia/reperfusion injury by induction of heme oxygenase-1. Ann Surg., 2007; 245: 931-42 (IF: 7.678)

Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BH The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol., 2007; 39: 2278-88 (IF: 4.804)

Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer CI, Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure. Mol Pharmacol., 2007; 72: 1647-56 (IF: 4.469)

2008

Hoetzel A, Welle A, Schmidt R, Loop T, Humar M, Ryter SW, Geiger KK, Choi AM, Pannen BH: Nitric oxide-deficiency regulates hepatic heme oxygenase-1. Nitric Oxide 2008; 18:61-69 (IF: 2.509)

Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer CI, LoopT,Geiger KK, Pahl HL, Pannen BH Thionamides inhibit the transcription factor NF-κB by suppression of the small GTPase Rac1 and IKKα. J Pharmacol Exp Ther 2008; 324:1037-44 (IF: 3.956)

Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL, Pannen BHJ, Loop T Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70. J Pharmacol Exp Ther 2008; 325:217-25. (IF: 3.956)

Goebel U, Siepe M, Mecklenburg A, Stein P, Roesslein M, Schwer C, Schmidt R, Doenst T, Geiger KK, Pahl HL, Schlensak C, Loop T Carbon Monoxide Inhalation Reduces Pulmonary Inflammatory Response during Cardiopulmonary Bypass in Pigs. Anesthesiology 2008;108(6): 1025-36. (IF: 4.207)

Steinmann D, Stahl CA, Minner J, Schumann S, Loop T, Kirschbaum A, Priebe H-J, Guttmann J. Electrical Impedance Tomography for verification of correct double-lumen tube placement: a Feasibility Study. Brit J Anaesth, 2008 (in press). (IF: 2.679)

Goebel U, Siepe M, Mecklenburg A, Stein P, Beyersdorf F, Loop T, Schlensak C: Reduced pulmonary inflammatory response during cardiopulmonary bypass: Effects of combined pulmonary perfusion and carbon monoxide inhalation. European Journal of Cardio-Thoracic Surgery 2008; in press (IF: 2.106)

Goebel U, Siepe M, Mecklenburg A, Doenst T, Benk C, Stein P, Beyersdorf F, Loop T, Schlensak C Pulsatile Pulmonary Perfusion During Cardiopulmonary Bypass Reduces the Pulmonary Inflammatory Response. Ann Thorac Surg 2008; 86:115-22 (IF: 2.022)

Reviews

Loop T., Priebe HJ.: Die arterielle Hypertonie: ihre Bedeutung für die perioperative Morbidität und Mortalität. Anasthesiol Intensivmed Notfallmed Schmerzther 1998; 33:292-299 (IF: 0.310)

Loop T., Priebe HJ.: Remifentanil – Einsatz in der ambulanten Anästhesie. Acta Anaesthesiol Helv 1999; 1:12-19 (not in JCR)

Mols G., Loop T., Geiger K., Farthmann E., Benzing A.: Extracorporeal membrane oxygenation: a ten-year experience. Am J Surg 2000,180:144-154 (IF: 2.183)

Mols G., Loop T., Hermle G., Buttler J., Huber B., Schubert J., Benzing A.: 10 years experience with extracorporeal membrane oxygenation. Anasthesiol Intensivmed Notfallmed Schmerzther 2001; 36:4-14 (IF: 0.310)

Loop T.: Das Immunsystem: Grundlagen und Modulation durch Anästhetika. Anästhesiologie und Intensivmedizin 2003; 44:53-67 (IF: 0.612)

Loop T., Pahl HL.: Activators and target genes of Rel/NF-κB transcription factors - from bench to bedside. In: Beyaert R: Nuclear Factor κB – Regulation and role in disease. Kluwer Publishing Group, 2003 (book chapter)

Pannen B.H.J., Loop T.: Evidenzbasierte Intensivtherapie des erhöhten intrakraniellen Drucks nach Schädel-Hirn-Trauma. Der Anaesthesist 2005; 54:126-137 (IF: 0.982)

Miscellaneous

Loop T., Priebe HJ.: Costs of anaesthesia. Eur J Anaesthesiol. 2005;22:162

Denschlag D., Loop T., Klisch J., Tempfer C., Anders B., Karck U.: Thrombolytic therapy and combined cesarean section and hysterectomy in prosthetic mitral valve thrombosis in pregnancy. Acta Obstet Gynecol Scand. 2005;84:404-6

Loop T.: Praxishandbuch Anästhesie – Lungenchirurgie; Hrsg. Benzing/Pannen, Spitta Verlag, April 2006 (book chapter)

Studium / Beruf

Wissenschaftliche Tätigkeit

Lehrtätigkeit

Gutachtertätigkeit

• Apoptosis
• Microbial Pathogenesis
• Pancreas
• Pharmacological Research

Mitgliedschaften in Fachgesellschaften

• Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin
• Deutscher Hochschulverband
• European Society of Anesthesiology
• European Pancreatic Club
• International Anesthesia Research Society
• International Association of Pancreatology

Originalarbeiten

Zarbock A, Schmidt C, Van Aken H, Wempe C, Martens S, Zahn PK, Wolf B, Goebel U, Schwer CI, Rosenberger P, Haeberle H, Görlich D, Kellum JA, Meersch M; RenalRIPC Investigators. Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. JAMA. 2015 Jun 2;313(21):2133-41.

Schwer CI, Lehane C, Guelzow T, Zenker S, Strosing KM, Spassov S, Erxleben A, Heimrich B, Buerkle H, Humar M. Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. PLOS One 2013, 8(10): e77258.       

Lehane C, Guelzow T, Zenker S, Erxleben A, Schwer CI, Heimrich B, Buerkle H, Humar M. Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro. J Pharmacol Exp Ther 2013, 347(3):781-93.

Schwer CI, Stoll P, Rospert S, Fitzke E, Schallner N, Buerkle H, Schmidt R, Humar M. Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2. Int J Biochem Cell Biol 2013, 45:201-12.

Schallner N, Fuchs M, Schwer CI, Loop T, Buerkle H, Lagrèze WA, van Oterendorp C, Biermann J, Goebel U. Postconditioning with inhaled CO counteracts apoptosis and neuroinflammation in the ischemic rat retina. PLoS One 2012, 7:e46479.                                                              

Stoll P, Schwer CI, Goebel U, Buerkle H, Hoetzel A, Schmidt R. Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver. World J Gastroenterol 2011, 17:4184-90.                               

Schwer CI, Stoll P, Goebel U, Buerkle H, Hoetzel A, Schmidt R. Effects of hydrogen sulfide on rat pancreatic stellate cells. Pancreas 2012, 41:74-83.

Schallner N, Schwemmers S, Schwer CI, Froehlich C, Stoll P, Humar M, Pahl HL, Hoetzel A, Loop T, Goebel U. p38ß-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro. Eur J Pharmacol 2011, 670:58-66.   

Biermann J, Lagrèze WA, Schallner N, Schwer CI, Goebel U. Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. Mol Vis 2011,17:1275-86.                                                         

Goebel U, Siepe M, Schwer CI, Schibilsky D, Brehm K, Priebe HJ, Schlensak C, Loop T. Postconditioning of the lungs with inhaled carbon monoxide after cardiopulmonary bypass in pigs. Anesth Analg 2011, 112:282-91.                                

Schwer CI*, Stoll P*, Pietsch U, Stein P, Laqua J, Goebel U, Hoetzel A, Schmidt R. Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. *geteilte Erstautorenschaft. Int J Biochem Cell Biol 2010, 42:1876-83. 

Goebel U, Siepe M, Schwer CI, Schibilsky D, Foerster K, Neumann J, Wiech T, Priebe HJ, Schlensak C, Loop T. Inhaled carbon monoxide prevents acute kidney injury in pigs after cardiopulmonary bypass by inducing a heat shock response.                       Anesth Analg 2010, 111:29-37.

Schwer CI, Mutschler M, Stoll P, Goebel U, Humar M, Hoetzel A, Schmidt R. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol Pharmacol 2010, 77(4):660-9. 

Goebel U, Mecklenburg A, Siepe M, Roesslein M, Schwer CI, Pahl HL, Priebe HJ, Schlensak C, Loop T. Protective effects of inhaled carbon monoxide in pigs during cardiopulmonary bypass are mediated via an induction of the heat shock response. Br J Anesth 2009, 103:173-84.

Steinmann D, Goebel U , Schwer CI, Freising C, Broß T, Strosing KM, Schmutz A, Geiger K, Heringhaus C. Teaching emergency medicine at the University Medical Center Freiburg: Establishment of an integrative concept. Anaesthesist 2008, 57:1193-1200.  

Schwer CI, Guerrero AM, Humar M, Roesslein M, Goebel U, Stoll P, Geiger KK, Pannen BH, Hoetzel A, Schmidt R. Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase 1/2 pathway. J Pharmacol Exp Ther 2008, 327:863-71.

Goebel U, Siepe M, Mecklenburg A, Stein P, Roesslein M, Schwer CI, Schmidt R, Doenst T, Geiger KK, Pahl HL, Schlensak C, Loop T. Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs. Anesthesiology 2008, 108:1025-36.       

von Dobschuetz E*, Schmidt R*, Scholtes M, Thomusch O, Schwer CI, Geiger KK, Hopt UT, Pannen BHJ. Protective role of heme oxygenase-1 in pancreatic microcirculatory dysfunction after ischemia/reperfusion in rats. * geteilte Erstautorenschaft. Pancreas 2008, 36:377-84. 

Roesslein M, Frick M, Auwaerter V, Humar M, Goebel U, Schwer CI, Geiger KK, Pahl HL, Pannen BH, Loop T. Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg 2008, 106:1150-60.

Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer CI, Humar M, Schmidt R, Geiger KK, Pahl HL, Pannen BH, Loop T. Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70. J Pharmacol Exp Ther 2008, 325:217-25.

Humar M, Dohrmann H, Stein P, Andriopoulus N, Goebel U, Roesslein M, Schmidt R, Schwer CI, Loop T, Geiger KK,  Pahl HL, Pannen BH. Thionamides inhibit the transcription factor nuclear factor-kappaB by suppression of Rac1 and inhibitor of kappaB kinase alpha. J Pharmacol Exp Ther. 2008, 324(3):1037-44.

Humar M, Dohrmann H, Stein P, Andriopoulus N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer CI, Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH. Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure. Mol Pharmacol. 2007, 72(6):1647-56.  

Übersichtsarbeiten

Schwer CI. Carbon monoxide and the pancreas. Curr Pharm Biotechnol 2012, 13:813-8.

Ausführliche Kongressbeiträge

Stoll P, Schwer CI, Stein P, Pietsch U, Laqua J, Schmidt R. Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. 84^st Congress of the International Anesthesia Research Society, Honolulu, Hawai, USA. Anesth Analg 2010, 110:282.

Schwer CI, Stoll P, Schmidt R. Carbon monoxide releasing molecule-2 inhibits rat pancreatic stellate cell proliferation by up-regulation of heme oxygenase-1. 84^st Congress of the International Anesthesia Research Society, Honolulu, Hawai, USA. Anesth Analg 2010, 110:412.

Goebel U, Siepe M, Schwer CI, Schlensak C, Loop T. Therapeutisch appliziertes, inhalatives Kohlenmonoxid vermindert den Lungenschaden nach kardiopulmonalem Bypass im Schwein. Anaesth Intensivmed 2010, 51:398.

Schwer CI, Guerrero AM, Goebel U, Stoll P, Geiger KK, Hoetzel A, Schmidt R. Das Enzym Hämoxygenase-1 hemmt die Proliferation primärer pankreatischer Sternzellen über einen ERK1/2-abhängigen Mechanismus. HAI 2008, Der Hauptstadtkongress der DGAI. Anästh Intensivmed 2008, 49:253-4.