Section of Neuroelectronic SystemsDepartment of Neurosurgery

Scientific publications

• Boehler C, Kleber C, Martini N, Xie Y, Dryg I, Stieglitz T, Hofmann UG, Asplund M. Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study. Biomaterials. 2017 Mar 13;129:176-187. http://dx.doi.org/10.1016/j.biomaterials.2017.03.019
• Hesse N, Schroder AS, Muller-Felber W, Bodensteiner C, Arens M, Hofmann UG. Body pose estimation in depth images for infant motion analysis. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1909-1912. http://dx.doi.org/10.1109/EMBC.2017.8037221
• Xie Y, Harsan L-A, Bienert T, Kirch RD, von Elverfeldt D, Hofmann UG: Quantitative Evaluation of in vivo SD-OCT Measurement of Rat Brain Biomed Opt Express, 2017; 8 (2): 593-607. http://dx.doi.org/10.1364/BOE.8.000593

Scientific publications

• Argiti, K, Joseph K, Mottaghi S, Feuerstein TJ, Hofmann UG: Deep brain stimulation: increasing efficiency by alternative waveforms. Current Directions in Biomedical Engineering, 2016; 2 (1): 145-148. http://dx.doi.org/10.1515/cdbme-2016-0034
• Kahl L, Hofmann UG: Comparison of algorithms to quantify muscle fatigue in upper limb muscles based on sEMG signals. Med Eng Phys, 2016; 38 (11): 1260-1269. http://dx.doi.org/10.1016/j.medengphy.2016.09.009
• Neto S, Varatharajan R, Joseph K, Moser A: Nasal administration of leptin dose-dependently increases dopamine and serotonin outflow in the rat nucleus accumbens. J Neural Transm, 2016; 123 (11): 1247-1254. http://dx.doi.org/10.1007/s00702-016-1591-9
• Pinnell R, Almajidy RK, Hofmann UG: Versatile 3D-Printed Headstage Implant for Group Housing of Rats. J Neurosci Meth, 2016; 257: 134-138. : http://dx.doi.org/10.1016/j.jneumeth.2015.09.027
• Pinnell R, Almajidy RK, Kirch RD, Cassell JC, Hofmann UG: A Novel, Wireless EEG Recording Method for use Inside the Water Maze. Plos One, 2016; 11 (2): 1-15. : http://dx.doi.org/10.1371/journal.pone.0147730
• Rassner MP, Moser A, Follo M, Joseph K, van Velthoven-Wurster V, Feuerstein TJ: Neocortical GABA release at high intracellular sodium and low extracellular calcium: an anti-seizure mechanism. J Neurochem, 2016; 137 (2): 177-189. http://dx.doi.org/10.1111/jnc.13555
• Windhorst S, Feuerstein TJ, Hofmann UG, Joseph K: Differences between human and animal neocortical tissue in transmitter release studies. Research Trends, 2016; 5:1-15.

Scientific publications

Journal Articles:

• Christ O, Hofmann UG: Video tracking of swimming rodents on a reflective water surface Current Directions in Biomedical Engineering, 2015; 1 (1): 232-235. : http://dx.doi.org/10.1515/cdbme-2015-0058
• Kahl L, Egers M, Hofmann UG: Effects on Sample Rate Limitation on Automated Fatigue Recognition Current Directions in Biomedical Engineering, 2015; 1 (1): 80-84. http://dx.doi.org/10.1515/cdbme-2015-0058
• Kirch RD, Pinnell R, Christ O, Hofmann UG, Cassell J-C: The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents. J Vis Exp. 2015 Jul 8;(101):e52667. http://dx.doi.org/10.3791/52667
• Pinnell RC, Almajidy RK, Hofmann UG. Versatile 3D-printed headstage implant for group housing of rodents. J Neurosci Methods. 2015 Oct 9;257:134-138. http://dx.doi.org/10.1016/j.jneumeth.2015.09.027
• Rassner MP, Hebel JM, Altenmüller DM, Volz S, Herrmann LS, Feuerstein TJ, Freiman TM. Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model. Seizure, 2015 Aug;30:6-13. http://dx.doi.org/10.1016/j.seizure.2015.05.002
• Varatharajan R, Joseph K, Neto SC, Hofmann UG, Moser A, Tronnier V. Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats. Neurochem Int. 2015 Nov;90:255-60. http://dx.doi.org/10.1016/j.neuint.2015.10.002

Editions (critical edition):

• Krüger J, Hofmann UG: (Hrsg.) ;Krüger J und Hofmann UG: The chronic challenge - new vistas on long-term multisite contacts to the central nervous system , : Frontiers, 2015 (Frontiers in Neuroengineering Research Topics). : http://10.3389/978-2-88919-508-4 (download: http://www.frontiersin.org/books/The_chronic_challenge_-_new_vistas_on_long-term_multisite_contacts_to_the_central_nervous_system/590)

Conference Papers:

• Almajidy R, Le KS, Hofmann UG: Novel near infrared sensors for hybrid BCI applications SPIE, 2015 (online). : http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2397949 (in Druck)
• Almajidy RK, Boudria Y, Hofmann UG, Besio W, Mankodiya K: A Multimodal 2D Brain Computer Interface 2015 (online) (EMBC Annual Meeting, Milano), IEEE (Hrsg). Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:1067-70; http://dx.doi.org/10.1109/EMBC.2015.7318549
• Hassler C, Ehler N, Singh V, Xie Y, Martini N, Kirch RD, Prucker O, Rühe JR, Hofmann UG, Stieglitz T: Fabrication and Implantation of Hydrogel Coated, Flexible Polyimide Electrodes. IEEE Express, 2015 (online) (7th Int'l IEEE EMBS Neural Engineering Conference -NER 2015). (in Druck)
• Mottaghi S, Hofmann UG: Dynamically Adjusted Scalable Electrical Stimulator for Exciteable Tissue IEEE Express, 2015 (online) (7th Int'l IEEE EMBS Neural Engineering Conference -NER 2015). (in Druck)
• Mottaghi S, Pinnel R, Hofmann UG: A 16-bit high-voltage digital charge-control electrical stimulator. IFMBE, 2015 (IFMBE World Congress on Biomedical Engineering and Medical Physics, Toronto.). (in Druck)
• Somerlik-Fuchs KH, Hofmann UG, Stieglitz T, Schulze-Bonhage A: The Influence of Stimulation Parameters on the Relative Phase Clustering Index. IEEE Express, 2015 (online) (7th Int'l IEEE EMBS Neural Engineering Conference -NER 2015). (in Druck)

Other publications (type Sonstiges):

• Hofmann UG, Krüger J: The chronic challenge - new vistas on long-term multisite contacts to the central nervous system Frontiers in Neuroengineering, 2015: 1-2. : http://doi: 10.3389/fneng.2015.00003 (download: http://journal.frontiersin.org/article/10.3389/fneng.2015.00003/full)

Xie, Y., T. Heida, J. Stegenga, Y. Zhao, A. Moser, V. Tronnier, T.J. Feuerstein, and U.G. Hofmann, High frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors. Europ. J. Neuroscience, 2014. doi: 10.1111/ejn.12736

Xie, Y., N. Martini, C. Hassler, R.D. Kirch, T. Stieglitz, A. Seifert, and U.G. Hofmann, In vivo monitoring of glial scar proliferation on chronically implanted neural electrodes by fiber optical coherence tomography. Frontiers in Neuroengineering, 2014. doi: 10.3389/fneng.2014.00034

Varatharajan, R., K. Joseph, S. Loeffler, H. Fuellgraf, U. G. Hofmann and A. Moser (2014). N-Methyl-D-Aspartate Receptor Activation Interacts with electrical High Frequency Stimulation in the Rat Caudate Nucleus in vitro and in vivo. Open Journal of Neuroscience 4 (2). doi: 10.13055/ojns_4_1_1.140312

Xie, Y., C. Hassler, A. Seifert, T. Stieglitz, and U.G. Hofmann, In-situ monitoring of brain tissue reaction of chronically implanted electrodes with an optical coherence tomography fiber system, in SPIE BIOS. 2014: San Francisco.

Somerlik-Fuchs, K., O. Christ, M. Duempelmann, U. Hofmann, T. Stieglitz, and A. Schulze-Bonhage. Development of a closed loop stimulation system for epilepsy therapy. in Proc. 6th European Conference of the International Federation for Medical and Biological Engineering (MBEC 2014). 2014. Dubrovnik, Croatia: IFMBE.

Hazrati, M., R. Almajidi, S. Oung, and U.G. Hofmann, Controlling a simple hand prosthesis using brain signals. Biomedical Engineering - Biomed. Tech., 2014. 59(s1).

Almajidy, R., R. Kirch, O. Christ, and U.G. Hofmann, Estimating the spatial resolution of fNIRS sensors for BCI purposes, in Proc. SPIE 8945, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI. 2014, SPIE Digital Library: San Francisco. p. 894504.

Merrison-Hort R, Yousif N, Njap F, Hofmann UG, Burylko O, Borisyuk R: An interactive channel model of the Basal Ganglia: bifurcation analysis under healthy and parkinsonian conditions. J Math Neurosci. 2013 Aug 14;3(1):14. doi:10.1186/2190-8567-3-14.

Richter, A, Xie, Y, Schumacher, A, Löffler, S, Kirch, RD, Al-Hasani, J., Rapoport, D. H., Kruse, C, Moser, A, Tronnier, V, Danner, S, Hofmann, UG: A simple implantation method for flexible, multisite microelectrodes into rat brains. Frontiers in Neuroengineering, 2013; 1-6 (ausschließlich online): doi:10.3389/fneng.2013.00006

Xie Y, Bonin T, Löffler S, Hüttmann G, Tronnier V, Hofmann UG. Coronal in vivo forward-imaging of rat brain morphology with an ultra-small optical coherence tomography fiber probe. Phys Med Biol 2013, 58(3), 555-568 Epub ahead of print .

Chamadiya B, Mankodiya K, Wagner M, Hofmann UG; Textile-based, contactless ECG monitoring for non-ICU clinical settings. Journal of Ambient Intelligence and Humanized Computing, 2012. DOI 10.1007/s12652-012-0153-8

Claussen JC, Hofmann UG; Sleep, neuroengineering and dynamics - Editorial. Cogn Neurodyn 2012, 6 (3/4)p. 211-214.

Christ O, Hofmann UG; A remote controlled food dispenser for animal research, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 542-545.

Hazrati MK, Hofmann UG; Decoding finger movements from ECoG signals using Empirical Mode Decomposition, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 655-558.

Klimach P, Richter A, et al.; Automated image analysis of immunohistochemical stained brain slices of long term polyimid brain implants, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 483-486.

Löffler S, Xie Y, et al.; An implantation technique for polyimide based flexible array probes facilitating neuronavigation and chronic implantation, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 860-863.

Löffler S, Xie Y, et al.: Long term in vivo stability and frequency response of polyimide based flexible array probes, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 103-106.

Oung S, Pohl BM, Hofmann UG; Preliminary design of a tendon-based anthropomorphic robotic hand, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 936-936.

Xie Y, Chen L, Hofmann UG; Reduction of periodic noise in Fourier domain optical coherence tomography images by frequency domain filtering, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 832-834.

Njap F, Claussen JC, Moser A, Hofmann UG; Modeling effect of GABAergic Current in a Basal Ganglia computational model. Cognitive Neurodynamics, 2012. 6(4): p. 333-341.

Nitz CV, Schlichting S, Pöhlsen S, Hofmann UG; Web Service-based presentation of vital signs on mobile devices, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 721-724.

Michalski T, Bonsanto MM, et al.; Service based adhoc networking for patient‘s pain diary on mobile devices, in Biomed Tech 57 (Suppl 1), O. Dössel, Editor. 2012, Walter de Gruyter: Jena. p. 1000-1003.

Vogt SM, Hofmann UG; Neuromodulation of STDP through short-term changes in firing causality. Cognitive Neurodynamics, 2012. 6(4): p. 353-366.

• Xie, Y., N. Martini, C. Hassler, R. Kirch, T. Stieglitz, and U.G. Hofmann, Online monitoring of neuroinflammation induced by chronic implanted microelectrode using a fiber-based OCT, in Proc. 48th Annual Conference of the German Society for Biomedical Engineering (BMT 2014), O. Dössel, Editor. 2014, DeGruyter: Hannover.
• Somerlik-Fuchs, K., O. Christ, M. Duempelmann, U. Hofmann, T. Stieglitz, and A. Schulze-Bonhage, Smart devices In epilepsy therapy: Animal research for closed-loop stimulation devices, in Proc. 48th Annual Conference of the German Society for Biomedical Engineering (BMT 2014), O. Dössel, Editor. 2014, DeGruyter: Hannover.
• Mottaghi, S., T. Helgason, and U.G. Hofmann, A scalable multi-channel modular electrical stimulator for therapeutic field steering, in Proc. 48th Annual Conference of the German Society for Biomedical Engineering (BMT 2014), O. Dössel, Editor. 2014, DeGruyter: Hannover.
• Asplund, M., C. Böhler, S. Heizmann, U. Egert, U.G. Hofmann, and T. Stieglitz, Polymer electrodes for drug release during stimulation, in Proc. 48th Annual Conference of the German Society for Biomedical Engineering (BMT 2014), O. Dössel, Editor. 2014, DeGruyter: Hannover
  
  

Digital Poster at the Annual Brainlinks-Braintools Workshop (Freiburg, Sept 2014):

Deep Brain Stimulation affects place learning in rats - Richard Pinnell, Robert Kirch, Patrick Pflüger, Jean-Christoph Cassell, Ulrich G. Hofmann

Image processing and video tracking for animal behavioral experiments - Olaf Christ, Karin Somerlik, Ulrich G. Hofmann

Group housing of brain stimulated lab rodents - Rand Almajdy, Richard Pinnell, Ulrich G. Hofmann

First ever optical online monitoring of brain implants - Yjing Xie, Ian Drygg, Ulrich G. Hofmann

A scalable multi-channel modular electrical stimulator for therapeutic field steering - Soheil Mottaghi, Ulrich G. Hofmann

Towards safe optogenetics with grafted cell implants - Mate Döbrössy, Lisa-Marie Selesnew, Yijing Xie, Robert Kirch, Ulrich G. Hofmann

Towards a mobile mini-robot as rat avatar - Soheil Mottaghi, Ulrich G. Hofmann

High frequency electrical stimulation suppresses cholinergic accumbens interneurons - Yjing Xie, Robert Kirch, Thomas Feuerstein, Ulrich G. Hofmann

rPCI and the analysis of long term recordings of epileptic rats - Karin Somerlik, Andreas Schulze-Bonhage, Thomas Stieglitz, , Ulrich G. Hofmann

Novel near infrared sensors for BCI applications - Rand Almajidy, Khang S. Le , Ulrich G. Hofmann