Abteilung InfektiologieKlinik für Innere Medizin II

Weisser M, Theilacker C, Sutter ST, Babikir R, Bertz H, Götting T, Dettenkofer M, Kern WV, Widmer AF; for the Hospital Infection Surveillance System for Patients with Haematologic/Oncologic Malignancies Study Group (ONKO-KISS). Secular trends of bloodstream infections during neutropenia in 15,181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS). Clin Microbiol Infect 2017 Mar 30. [Epub ahead of print]

Joost I, Kaasch A, Pausch C, Peyerl-Hoffmann G, Schneider C, Voll RE, Seifert H, Kern WV, Rieg S. Staphylococcus aureus bacteremia in patients with rheumatoid arthritis - data from the prospective INSTINCT cohort. J Infect 2017 Mar 18. [Epub ahead of print]

Kohler V, Probst I, Aufschnaiter A, Büttner S, Schaden L, Rechberger GN, Koraimann G, Grohmann E, Keller W. Conjugative type IV secretion in Gram-positive pathogens: TraG, a lytic transglycosylase and endopeptidase, interacts with translocation channel protein TraM. Plasmid 2017; 91:9-18.

Ruffing U, Alabi A, Kazimoto T, Vubil DC, Akulenko R, Abdulla S, Alonso P, Bischoff M, Germann A, Grobusch MP, Helms V, Hoffmann J, Kern WV, Kremsner PG, Mandomando I, Mellmann A, Peters G, Schaumburg F, Schubert S, Strauß L, Tanner M, Briesen HV, Wende L, Müller LV, Herrmann M. Community-associated Staphylococcus aureus from Sub-Saharan Africa and Germany: a cross-sectional geographic correlation study. Sci Rep 2017; 7:154.

Mischnik A, Baumert P, Hamprecht A, Rohde AM, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; for the DZIF-ATHOS Study Group. In vitro susceptibility to 19 agents other than β-lactams among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. J Antimicrob Chemother 2017 Jan 19. [Epub ahead of print]

Hos NJ, Jazmati N, Stefanik D, Hellmich M, AlSael H, Kern WV, Rieg S, Wisplinghoff H, Seifert H, Kaasch AJ. Determining vancomycin Etest MICs in patients with MRSA bloodstream infection does not support switching antimicrobials. J Infect 2017; 74:248-59.

Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; for the DZIF-ATHOS Study Group. Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. Int J Antimicrob Agents 2017; 49:239-42.

Mischnik A, Baumert P, Hamprecht A, Rohde A, Peter S, Feihl S, Knobloch J, Gölz H, Kola A, Obermann B, Querbach C, Willmann M, Gebhardt F, Tacconelli E, Gastmeier P, Seifert H, Kern WV; for the DZIF-ATHOS Study Group. Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. Diagn Microbiol Infect Dis 2017; 87:71-3.

Anjum R, Grohmann E, Krakat N. Anaerobic digestion of nitrogen rich poultry manure: Impact of thermophilic biogas process on metal release and microbial resistances. Chemosphere 2017; 168:1637-47.

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A,Henneke P, Triantafyllopoulou A. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell. 2016;167:1264-1280.

Bender JK, Fleige C, Klare I, Fiedler S, Mischnik A, Mutters NT, Dingle KE, Werner G. Detection of a cfr(B) Variant in German Enterococcus faecium clinical isolates and the impact on linezolid resistance in Enterococcus spp. PLoS One 2016; 11:e0167042.

Joost I, Steinfurt J, Meyer PT, Kern WV, Rieg S. Staphylococcus aureus bacteremia with iliac artery endarteritis in a patient receiving ustekinumab. BMC Infect Dis 2016; 16:586.

Rieg S, Joost I, Weiß V, Peyerl-Hoffmann G, Schneider C, Hellmich M, Seifert H, Kern WV, Kaasch A. Combination antimicrobial therapy in patients with Staphylococcus aureus bacteremia - a post hoc analysis in 964 prospectively evaluated patients. Clin Microbiol Infect 2016 S1198-743X(16)30370-6.

Hamprecht A, Rohde AM, Behnke M, Feihl S, Gastmeier P, Gebhardt F, Kern WV, Knobloch JK, Mischnik A, Obermann B, Querbach C, Peter S, Schneider C, Schröder W, Schwab F, Tacconelli E, Wiese-Posselt M, Wille T, Willmann M, Seifert H, Zweigner J; DZIF-ATHOS Study Group. Colonization with third-generation cephalosporin-resistant Enterobacteriaceae on hospital admission: prevalence and risk factors. J Antimicrob Chemother 2016; 71:2957-63.

Pollack LA, Plachouras D, Sinkowitz-Cochran R, Gruhler H, Monnet DL, Weber JT; Transatlantic Taskforce on Antimicrobial Resistance (TATFAR) Expert Panel on Stewardship Structure and Process Indicators. A concise set of structure and process indicators to assess and compare antimicrobial stewardship srograms among EU and US hospitals: results from a multinational expert panel. Infect Control Hosp Epidemiol 2016; 37:1201-11.

Goetting T, Klassen S, Jonas D, Benk C, Serr A, Wagner D, Ebner W. Heater-cooler units - contamination of crucial devices in cardiothoracic surgery! J Hosp Infec 2016; 93:223-8.

Borde JP, Nussbaum S, Hauser S, Hehn P, Hübner J, Sitaru G, Köller S, Schweigert B, deWith K, Kern WV, Kaier K. Implementing an intensified antibiotic stewardship programme targeting daptomycin use in orthopaedic surgery: a cost-benefit analysis from the hospital perspective. Infection 2016; 44:301-7.

Albrecht C, Ringshausen F, Ott S, Wagner D, Rademacher J, Schneider M, Welte T, Pletz MW. Should all adult cystic fibrosis patients with repeated NTM cultures receive treatment? Eur Resp J 2016; 47:1575-7.

Paganelli FL, Huebner J, Singh KV, Zhang X, van Schaik W, Wobser D, Braat JC, Murray BE, Bonten MJ, Willems RJ, Leavis HL. Genome-wide screening identifies phosphotransferase system permease BepA to be involved in Enterococcus faecium endocarditis and biofilm formation. J Infect Dis 2016; 214:189-95.

Bätzing-Feigenbaum J, Schulz M, Schulz M, Hering R, Kern WV. Antibiotikaverordnung in der ambulanten Versorgung – eine bevölkerungsbezogene Untersuchung in Deutschland zum regionalen, altersgruppenbezogenen Verbrauch von Cephalosporinen und Fluorchinolonen. Dtsch Ärztebl 2016; 113:455-9.

Fätkenheuer G, Jessen H, Stoehr A, Jung N, Jessen AB, Kümmerle T, Berger M, Bogner JR, Spinner CD, Stephan C, Degen O, Vogelmann R, Spornraft-Ragaller P, Schnaitmann E, Jensen B, Ulmer A, Kittner JM, Härter G, Malfertheiner P, Rockstroh J, Knecht G, Scholten S, Harrer T, Kern WV, Salzberger B, Schürmann D, Ranneberg B. PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis. HIV Med 2016; 17:453-9.

Schuster S, Vavra M, Kern WV. Evidence of a substrate discriminating entrance channel in the lower porter domain of the multidrug resistance efflux pump AcrB. Antimicrob Agents Chemother 2016; 60:4315-23.

Fercher C, Probst I, Kohler V, Goessweiner-Mohr N, Arends K, Grohmann E, Zangger K, Meyer NH, Keller W. VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis. Sci Rep 2016; 6:24643.

Ringshausen FC, Wagner D, de Roux A, Diel R, Hohmann D, Hickstein L, Welte T, Rademacher J. Prevalence of nontuberculous mycobacterial pulmonary disease, Germany, 2009–2014. Emerg Infect Dis 2016; 22:1102-5.

Diederich AK, Duda KA, Romero-Saavedra F, Engel R, Holst O, Huebner J. Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines. Innate Immun 2016; 22:284-93.

Fiedler S, Bender JK, Klare I, Halbedel S, Grohmann E, Szewzyk U, Werner G. Tigecycline resistance in clinical isolates of Enterococcus faecium is mediated by an upregulation of plasmid-encoded tetracycline determinants tet(L) and tet(M). J Antimicrob Chemother 2016; 71:871-81.

Teófilo E, Rocha-Pereira N, Kuhlmann B, Antela A, Knechten H, Santos J, Jiménez-Expósito MJ; REMAIN study group. Long-term efficacy, tolerability, and renal safety of atazanavir/ritonavir-based antiretroviral therapy in a cohort of treatment-naïve patients with HIV-1 infection: the REMAIN study. HIV Clin Trials 2016; 17:17-28.

Nöstlinger C, Platteau T, Bogner J, Buyze J, Dec-Pietrowska J, Dias S, Newbury-Helps J, Kocsis A, Mueller M, Rojas D, Stanekova D, van Lankveld J, Colebunders R. Computer-assisted intervention for safer sex in HIV-positive men having sex with men: findings of a European randomized multi-center trial. J Acquir Immune Defic Syndr 2016; 71:e63-72.

Bohnert J, Schuster S, Kern WV, Karcz T, Olejarz A, Kaczor A, Handzlik J, Kieć-Kononowicz K. Novel piperazine arylideneimidazolones inhibit the AcrAB-TolC pump in Escherichia coli and simultaneously act as fluorescent membrane probes in a combined real-time influx and efflux assay. Antimicrob Agents Chemother 2016; 60:1974-83.

Strauß L, Ruffing U, Abdulla S, Alabi A, Akulenko R, Garrine M, Germann A, Grobusch MP, Helms V, Herrmann M, Kazimoto T, Kern W, Mandomando I, Peters G, Schaumburg F, von Müller L, Mellmann A. Detecting Staphylococcus aureus virulence and resistance genes: a comparison of whole-genome sequencing and DNA microarray technology. J Clin Microbiol 2016; 54:1008-16.

Theilacker C, Ludewig K, Serr A, Schimpf J, Held J, Bögelein M, Bahr V, Rusch S, Pohl A, Kogelmann K, Frieseke S, Bogdanski R, Brunkhorst FM, Kern WV. Overwhelming post-splenectomy infection: a prospective multicenter cohort study. Clin Infect Dis 2016; 62:871-8.

Burgey C, Kern WV, Römer W, Rieg S. Differential induction of innate defense antimicrobial peptides in primary nasal epithelial cells upon stimulation with inflammatory cytokines, Th17 cytokines or bacterial conditioned medium from Staphylococcus aureus isolates. Microb Pathog 2016; 90:69-77.

Walker M, Mabud TS, Olliaro PL, Coulibaly JT, King CH, Raso G, Scherrer AU, Stothard JR, Sousa-Figueiredo JC, Stete K, Utzinger J, Basáñez MG. New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel. Parasit Vectors 2016; 9:41.

Blauenfeldt T, Wagner D, Aabye M, Heyckendorf J, Lange L, Lange C, Ernst M, Ravn P, Duarte R, Morais C, Hoffmann M, Schoch O, Dominguez J, Latorre I, Ruhwald M. Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study. Tuberculosis (Edinb) 2016; 98:7-12.

Borde JP, Nussbaum S, Hauser S, Hehn P, Hübner J, Sitaru G, Köller S, Schweigert B, deWith K, Kern WV, Kaier K. Implementing an intensified antibiotic stewardship programme targeting daptomycin use in orthopaedic surgery: a cost-benefit analysis from the hospital perspective. Infection. 2016;44:301-7.

Krauth SJ, Greter H, Stete K, Coulibaly JT, Traoré SI, Ngandolo BN, Achi LY, Zinsstag J, N'Goran EK, Utzinger J. All that is blood is not schistosomiasis: experiences with reagent strip testing for urogenital schistosomiasis with special consideration to very-low prevalence settings. Parasit Vectors 2015; 8:584. (Pubmed)

Guzmán-Prieto AM, Urbanus RT, Zhang X, Bierschenk D, Koekman CA, van Luit-Asbroek M, Ouwerkerk JP, Pape M, Paganelli FL, Wobser D, Huebner J, Hendrickx AP, Bonten MJ, Willems RJ, van Schaik W. The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets. Sci Rep 2015; 5:18255. (Pubmed)

Christoph A, Ehm C, de With K. [Impact of an ABS training initiative on ABS structural quality of participating hospitals]. Z Evid Fortbild Qual Gesundhwes 2015; 109:521-7.

Kern WV, Fellhauer M, Hug M, Hoppe-Tichy T, Först G, Steib-Bauert M, de With K. [Recent antibiotic use in German acute care hospitals - from benchmarking to improved prescribing and quality care]. Dtsch Med Wochenschr. 2015 Nov;140(23):e237-e246. (Pubmed)

Rieg S, Küpper MF, de With K, Serr A, Bohnert JA, Kern WV. Intestinal decolonization of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBL): a retrospective observational study in patients at risk for infection and a brief review of the literature. BMC Infect Dis. 2015 Oct 28;15:475. (Pubmed)

Ichikawa K, van Ingen J, Koh WJ, Wagner D, Salfinger M, Inagaki T, Uchiya KI, Nakagawa T, Ogawa K, Yamada K, Yagi T. Genetic diversity of clinical Mycobacterium avium subsp. hominissuis and Mycobacterium intracellulare isolates causing pulmonary diseases recovered from different geographical regions. Infect Genet Evol. 2015;36:250-255. (Pubmed)

Mutters NT, Zimmermann S, Kaase M, Mischnik A. Activity of temocillin, mecillinam, ceftazidime, and ceftazidime/avibactam against carbapenem-non-susceptible Enterobacteriaceae without carbapenemase production. Eur J Clin Microbiol Infect Dis. 2015 Oct 3. [Epub ahead of print] (Pubmed)

Eichenberger EM, Thaden JT, Sharma-Kuinkel B, Park LP, Rude1TH, Ruffin F, Hos NJ, Seifert H, Rieg S, Kern WV, Lower SK, Fowler VG, Kaasch AJ. Polymorphisms in fibronectin binding proteins A and B among Staphylococcus aureus bloodstream isolates are not associated with arthroplasty infection. PLoS One 2015; 53:227-36. (Pubmed)

Kodali S, Vinogradov E, Lin F, Khoury N, Hao L, Pavliak V, Jones CH, Laverde D, Huebner J, Jansen KU, Anderson AS, Donald RG. A vaccine approach for the prevention of infections by multidrug-resistant Enterococcus faecium. J Biol Chem 2015; 290:19512-26. (Pubmed)

Romero-Saavedra F, Laverde D, Budin-Verneuil A, Muller C, Bernay B, Benachour A, Hartke A, Huebner J. Characterization of two metal binding lipoproteins as vaccine candidates for enterococcal infections. PLoS One 2015; 10:e0136625. (Pubmed)

Kaasch AJ, Fätkenheuer G, Prinz-Langenohl R, Paulus U, Hellmich M, Weiß V, Jung N, Rieg S, Kern WV, Seifert H; SABATO Trial Group. Early oral switch therapy in low-risk Staphylococcus aureus bloodstream infection (SABATO): study protocol for a randomized controlled trial. Trials 2015;16:450. (Pubmed)

Kohler P, Kuster SP, Bloemberg G, Schulthess B, Frank M, Tanner FC, Rössle M, Böni C, Falk V, Wilhelm MJ, Sommerstein R, Achermann Y, Ten Oever J, Debast SB, Wolfhagen MJ, Brandon Bravo Bruinsma GJ, Vos MC, Bogers A, Serr A, Beyersdorf F, Sax H, Böttger EC, Weber R, van Ingen J, Wagner D, Hasse B. Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery. Eur Heart J 2015; 36:2745-53. (Pubmed)

Olliaro PL, Vaillant M, Diawara A, Coulibaly JT, Garba A, Keiser J, King CH, Knopp S, Landouré A, N'Goran EK, Raso G, Scherrer AU, Sousa-Figueiredo JC, Stete K, Zhou XN, Utzinger J. Toward Measuring Schistosoma Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion. PLoS Negl Trop Dis 2015; 9:e0003821. (Pubmed)

Becker SL, Piraisoody N, Kramme S, Marti H, Silué KD, Panning M, Nickel B, Kern WV, Herrmann M, Hatz CF, N'Goran EK, Utzinger J, von Müller L. Real-time PCR for detection of Strongyloides stercoralis in human stool samples from Côte d'Ivoire: Diagnostic accuracy, inter-laboratory comparison and patterns of hookworm co-infection. Acta Trop 2015; 150:210-7. (Pubmed)

Zischka M, Künne CT, Blom J, Wobser D, Sakιnç T, Schmidt-Hohagen K, Dabrowski PW, Nitsche A, Hübner J, Hain T, Chakraborty T, Linke B, Goesmann A, Voget S, Daniel R, Schomburg D, Hauck R, Hafez HM, Tielen P, Jahn D, Solheim M, Sadowy E, Larsen J, Jensen LB, Ruiz-Garbajosa P, Quiñones Pérez D, Mikalsen T, Bender J, Steglich M, Nübel U, Witte W, Werner G. Comprehensive molecular, genomic and phenotypic analysis of a major clone of Enterococcus faecalis MLST ST40. BMC Genomics 2015; 16:175. (Pubmed)

Ocvirk S, Sava IG, Lengfelder I, Lagkouvardos I, Steck N, Roh JH, Tchaptchet S, Bao Y, Hansen JJ, Huebner J, Carroll IM, Murray BE, Sartor RB, Haller D. Surface-associated lipoproteins link Enterococcus faecalis virulence to colitogenic activity in IL-10-deficient mice independent of their expression levels. PLoS Pathog 2015; 11:e1004911. (Pubmed)

Letang E, Müller MC, Ntamatungiro AJ, Kimera N, Faini D, Furrer H, Battegay M, Tanner M, Hatz C, Boulware DR, Glass TR. Cryptococcal antigenemia in immunocompromised human immunodeficiency virus patients in rural Tanzania: a preventable cause of early mortality. Open Forum Infect Dis 2015; 2:ofv046. (Pubmed)

Cardot-Martin E, Casalegno JS, Badiou C, Dauwalder O, Keller D, Prévost G, Rieg S, Kern WV, Cuerq C, Etienne J, Vandenesch F, Lina G, Dumitrescu O. α-Defensins partially protect human neutrophils against Panton-Valentine leukocidin produced by Staphylococcus aureus. Lett Appl Microbiol 2015; 61:158-64. (Pubmed)

Stete K, Kern WV, Rieg S, Serr A, Maurer C, Tintelnot K, Wagner D. Importierte Histoplasmose. Dtsch Med Wochenschr 2015; 140: 913-6. (Pubmed)

Scholman T, Straub M, Sotgiu G, Elsäßer J, Leyking S, Singh M, Sester U, Wagner D, Sester M. Superior sensitivity of ex vivo IFN-g release assays as compared to skin-testing in immunocompromised patients. Am J Transplant 2015; 15: 2616-2624. (Pubmed)

Theilacker C, Diederich AK, Otto A, Sava IG, Wobser D, Bao Y, Hese K, Broszat M, Henneke P, Becher D, Huebner J. Enterococcus faecalis glycolipids modulate lipoprotein-content of the bacterial cell membrane and host immune response. PLoS One 2015; 10:e0132949. (Pubmed)

Borde JP, Häcker GA, Guschl S, Serr A, Danner T, Hübner J, Burrack-Lange S, Lüdke G, Helwig P, Hauschild O, Kern WV. Diagnosis of prosthetic joint infections using UMD-Universal Kit and the automated multiplex-PCR Unyvero i60 ITI® cartridge system: a pilot study. Infection 2015; 43:551-60. (Pubmed)

Pulcini C, Wencker F, Frimodt-Møller N, Kern WV, Nathwani D, Rodríguez-Baño J, Simonsen GS, Vlahović-Palčevski V, Gyssens IC; ESGAP Curriculum Working Group. European survey on principles of prudent antibiotic prescribing teaching in undergraduate students. Clin Microbiol Infect 2015; 21:354-61. (Pubmed)

Rossmann FS, Laverde D, Kropec A, Romero-Saavedra F, Meyer-Buehn M, Huebner J. Isolation of highly active monoclonal antibodies against multiresistant gram-positive bacteria. PLoS One 2015; 10:e0118405. (Pubmed)

Jechalke S, Broszat M, Lang F, Siebe C, Smalla K, Grohmann E. Effects of 100 years wastewater irrigation on resistance genes, class 1 integrons and IncP-1 plasmids in Mexican soil. Front Microbiol 2015; 6:163. (Pubmed)

Rossmann FS, Racek T, Wobser D, Puchalka J, Rabener EM, Reiger M, Hendrickx AP, Diederich AK, Jung K, Klein C, Huebner J. Phage-mediated dispersal of biofilm and distribution of bacterial virulence genes is induced by quorum sensing. PLoS Pathog 2015; 11:e100465. (Pubmed)

Guridi A, Diederich AK, Aguila-Arcos S, Garcia-Moreno M, Blasi R, Broszat M, Schmieder W, Clauss-Lendzian E, Sakinc-Gueler T, Andrade R, Alkorta I, Meyer C, Landau U, Grohmann E. New antimicrobial contact catalyst killing antibiotic resistant clinical and waterborne pathogens. Mater Sci Eng C Mater Biol Appl 2015; 50:1-11. (Pubmed)

Augustin J, Mangiapane S, Kern WV. A regional analysis of outpatient antibiotic prescribing in Germany in 2010. Eur J Public Health 2015; 25:397-9. (Pubmed)

Gross BN, Steib-Bauert M, Kern WV, Knoth H, Borde JP, Krebs S, Hug MJ, Rothe U, Maier L, de With K. Hospital use of systemic antifungal drugs: a multi-center surveillance update from Germany. Infection 2015; 43:423-9 . (Pubmed)

Burgey C, Kern WV, Römer W, Sakinc T, Rieg S. The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines. Microbes Infect 2015; 17:353-9. (Pubmed)

Borde JP, Litterst S, Ruhnke M, Feik R, Hübner J, deWith K, Kaier K, Kern WV. Implementing an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a 200-bed community hospital in Germany. Infection 2015; 43:45-50. (Pubmed)

Rossmann FS, Kropec A, Laverde D, Saaverda FR, Wobser D, Huebner J. In vitro and in vivo activity of hyperimmune globulin preparations against multiresistant nosocomial pathogens. Infection 2015; 43:169-75. (Pubmed)

Borde JP, Kern WV, Hug M, Steib-Bauert M, de With KD, Busch HJ, Kaier K. Implementation of an intensified antibiotic stewardship programme targeting third-generation cephalosporin and fluoroquinolone use in an emergency medicine department. Emerg Med J 2015; 32:509-15. (Pubmed)

Hos NJ, Rieg S, Kern WV, Jonas D, Fowler VG Jr, Higgins PG, Seifert H, Kaasch AJ. Amino acid alterations in fibronectin binding protein A (FnBPA) and bacterial genotype are associated with cardiac device related infection in Staphylococcus aureus bacteraemia. J Infect 2015; 70:153-9. (Pubmed)

Schuster S, Kohler S, Buck A, Dambacher C, König A, Bohnert JA, Kern WV. Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors. Antimicrob Agents Chemother 58 (2014) 6870-8.

Yamaguchi N, Roberts M, Castro S, Oubre C, Makimura K, Leys N, Grohmann E, Sugita T, Ichijo T, Nasu M. Microbial monitoring of crewed habitats in space-current status and future perspectives. Microbes Environ 29 (2014) 250-60.

Clotet B, Feinberg J, van Lunzen J, Khuong-Josses MA, Antinori A, Dumitru I, Pokrovskiy V, Fehr J, Ortiz R, Saag M, Harris J, Brennan C, Fujiwara T, Min S; ING114915 Study Team. Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study. Lancet 383 (2014) 2222-31.

Earnshaw S, Mancarella G, Mendez A, Todorova B, Magiorakos AP, Possenti E, Stryk M, Gilbro S, Goossens H, Albiger B, Monnet DL; European Antibiotic Awareness Day Technical Advisory Committee; European Antibiotic Awareness Day Collaborative Group. European Antibiotic Awareness Day: a five-year perspective of Europe-wide actions to promote prudent use of antibiotics. Euro Surveill 19 (2014) 20928.

Nurjadi D, Olalekan AO, Layer F, Shittu AO, Alabi A, Ghebremedhin B, Schaumburg F, Hofmann-Eifler J, Van Genderen PJ, Caumes E, Fleck R, Mockenhaupt FP, Herrmann M, Kern WV, Abdulla S, Grobusch MP, Kremsner PG, Wolz C, Zanger P. Emergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe. J Antimicrob Chemother 69 (2014) 2361-8.

Hufnagel M, Sixel K, Hammer F, Kropec A, Sava IG, Theilacker C, Berner R, Huebner J. Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations. Infection 42 (2014) 749-55.

Broszat M, Nacke H, Blasi R, Siebe C, Huebner J, Daniel R, Grohmann E. Wastewater irrigation increases abundance of potentially harmful Gammaproteobacteria in soils from Mezquital Valley, Mexico. Appl Environ Microbiol 80 (2014) 5282-91.

Helwig P, Morlock J, Oberst M, Hauschild O, Hübner J, Borde J, Südkamp NP, Konstantinidis L. Periprosthetic joint infection – effect on quality of life. Int Orthop 38 (2014) 1077-81.

Borde JP, Batin N, Rieg S, Feik R, Reimling C, Kern WV, de With K, Hübner J, Ruhnke M, Kaier K. Adherence to an antibiotic stewardship bundle targeting Staphylococcus aureus blood stream infections at a 200-bed community hospital. Infection 42 (2014) 713-9.

Borde JP, Kaier K, Steib-Bauert M, Vach W, Geibel-Zehender A, Busch H, Bertz H, Hug M, de With K, Kern WV. Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center. BMC Infect Dis 14 (2014) 201.

Diederich AK, Wobser D, Spiess M, Sava IG, Huebner J, Sakιnç T. Role of glycolipids in the pathogenesis of Enterococcus faecalis urinary tract infection. PLoS One 9 (2014) e96295.

Goessweiner-Mohr N, Eder M, Hofer G, Fercher C, Arends K, Birner-Gruenberger R, Grohmann E, Keller W. Structure of the double-stranded DNA-binding type IV secretion protein TraN from Enterococcus. Acta Crystallogr D Biol Crystallogr 70 (2014) 2376-89

Goessweiner-Mohr N, Fercher C, Arends K, Birner-Gruenberger R, Laverde-Gomez D, Huebner J, Grohmann E, Keller W. The type IV secretion protein TraK from the Enterococcus conjugative plasmid pIP501 exhibits a novel fold. Acta Crystallogr D Biol Crystallogr 70 (2014) 1124-35.

Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Dilektasli AG, Domínguez J, Duarte R, Ernst M, Eyuboglu FO, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ravn P, Scholman T, Soccal PM, Straub M, Wagner D, Wolf T, Yalcin A, Lange C; TBNET. Risk assessment of zuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med 190 (2014) 1168-76.

Haller C, Berthold M, Wobser D, Kropec A, Lauriola M, Schlensak C, Huebner J. Cell-wall glycolipid mutations and their effects on virulence of E. faecalis in a rat model of infective endocarditis. PLoS One 9 (2014) e91863.

Kaasch AJ, Barlow G, Edgeworth JD, Fowler VG Jr, Hellmich M, Hopkins S, Kern WV, Llewelyn M, Rieg S, Rodriguez-Baño J, Scarborough M, Seifert H, Soriano A, Tilley R, Tőrők ME, Weiß V, Wilson WR, Thwaites GE, on behalf of ISAC, UKCIRG, SABG, and INSTINCT. Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies. J Infect 68 (2014) 242-51.

Thern J, de With K, Strauss R, Steib-Bauert M, Weber N, Kern WV. Selection of hospital antimicrobial prescribing quality indicators: a consensus among German antibiotic stewardship (ABS) networkers. Infection 42 (2014) 351-62.

Kaasch AJ, Rieg S, Hellmich M, Kern WV, Seifert H. Differential time to positivity is not predictive for central line-related Staphylococcus aureus bloodstream infection in routine clinical care. J Infect. 68 (2014) 58-61.

Romero-Saavedra F, Laverde D, Wobser D, Michaux C, Budin-Verneuil A, Bernay B, Benachour A, Hartke A, Huebner J. Identification of peptidoglycan-associated proteins as vaccine candidates for enterococcal infections. PLoS One 9 (2014) e111880.

Laverde D, Wobser D, Romero-Saavedra F, Hogendorf W, van der Marel G, Berthold M, Kropec A, Codee J, Huebner J. Synthetic Teichoic Acid Conjugate Vaccine against Nosocomial Gram-Positive Bacteria. PLoS One 9 (2014) e110953.

Wobser D, Ali L, Grohmann E, Huebner J, Sakinc T. A novel role for D-alanylation of lipoteichoic acid of Enterococcus faecalis in urinary tract infection. PLoS ONE 9 (2014) e107827.

Diederich A-K, Wobser D, Spiess M, Sava IG, Huebner J, Sakιnç T. 2014. Role of glycolipids in the pathogenesis of Enterococcus faecalis urinary tract infection. PLoS ONE 9 (2014) e96295.

Rieg S, Saborowski V, Kern WV, Jonas D, Bruckner-Tuderman L, Hofmann SC. Expression of the sweat-derived innate defense antimicrobial peptide dermcidin is not impaired in Staphylococcus aureus colonisation and recurrent skin infections. Clin Exp Dermatol  39 (2014) 209-12.

Lübbert C, Schumacher U, Stareprawo S, Claus J, Heeß-Erler G, Fiebig C, de With K, Wilhelms D, Kekulé AS, Klöss T, Moritz S. Lässt sich die Antibiotikaverordnungspraxis im Krankenhaus durch hausinterne Richtlinien beeinflussen? Dtsch Med Wochenschr 139 (2014) 2578-84.

Castillo-Rojas G, Mazari-Hiríart M, Ponce de León S, Amieva-Fernández RI, Agis-Juárez RA, Huebner J, López-Vidal Y. Comparison of Enterococcus faecium and Enterococcus faecalis strains isolated from water and clinical samples: antimicrobial susceptibility and genetic relationships. PLoS One 8 (2013) e59491.

Shokoohizadeh L, Mobarez AM, Zali MR, Ranjbar R, Alebouyeh M, Sakinc T, Ali L. High frequency distribution of heterogeneous vancomycin-resistant Enterococcous faecium (VREfm) in Iranian hospitals. Diagn Pathol 8 (2013) 163.

Borde JP, Offensperger WB, Kern WV, Wagner D. Mycobacterium genavense specific mesenteritic syndrome in HIV-infected patients: a new entity of retractile mesenteritis? AIDS 27 (2013) 2819-22.

Timmer A, Günther J, Motschall E, Rücker G, Antes G, Kern WV. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev 2013; 10:CD006323

Buyle FM, Metz-Gercek S, Mechtler R, Kern WV, Robays H, Vogelaers D, Struelens MJ; members of the Antibiotic Strategy International (ABS) Quality Indicators Team. Development and validation of potential structure indicators for evaluating antimicrobial stewardship programmes in European hospitals. Eur J Clin Microbiol Infect Dis 32 (2013) 1161-70.

Arends K, Celik EK, Probst I, Goessweiner-Mohr N, Fercher C, Grumet L, Soellue C, Abajy MY, Sakin T, Broszat M, Schiwon K, Koraimann G, Keller W, Grohmann E. TraG encoded by the pIP501 type IV secretion system is a two domain peptidoglycan degrading enzyme essential for conjugative transfer. J Bacteriol 195 (2013) 4436-44.

Rieg S, Jonas D, Kaasch AJ, Porzelius C, Peyerl-Hoffmann G, Theilacker C, Küpper MF, Schneider C, Seifert H, Kern WV. Microarray-based genotyping and clinical outcomes of Staphylococcus aureus bloodstream infection: an exploratory study. PLoS One 8 (2013) e71259.

Huebner J, Rack-Hoch AL, Pecar A, Schmid I, Klein C, Borde JP. [Pilot project of a pediatric antibiotic stewardship initiative at the Hauner Children's Hospital.] Klin Pädiatr 2013 Jul 12. [Epub ahead of print]

Theilacker C, Held J, Allering L, Emmerich P, Schmidt-Chanasit J, Kern WV, Panning M. Prolonged polyarthralgia in a German traveller with Mayaro virus infection without inflammatory correlates. BMC Infect Dis 13 (2013) 369.

Schiwon K, Arends K, Rogowski KM, Fürch S, Prescha K, Sakinc T, Van Houdt R, Werner G, Grohmann E. Comparison of antibiotic resistance, biofilm formation and conjugative transfer of Staphylococcus and Enterococcus isolates from international space station and antarctic research station Concordia. Microb Ecol 65 (2013) 638-51.

Kaasch AJ, Rieg S, Kuetscher J, Brodt HR, Widmann T, Herrmann M, Meyer C, Welte T, Kern P, Haars U, Reuter S, Hübner I, Strauss R, Sinha B, Brunkhorst FM, Hellmich M, Fätkenheuer G, Kern WV, Seifert H. Delay in the administration of appropriate antimicrobial therapy in Staphylococcus aureus bloodstream infection: a prospective multicenter hospital-based cohort study. Infection 41 (2013) 979-85.

Falcone V, Bierbaum S, Bertz H, Kern WV, Kontny U, Huzly D, Panning M. Pandemic influenza virus A/H1N1 (2009) hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season. Arch Virol 158 (2013) 1297-303.

Bohnert J, Schuster S, Kern WV. Pimozide inhibits the AcrAB-TolC efflux pump in Escherichia coli.Open Microbiol J 7 (2013) 83-6.

Ringshausen FC, Apel RM, Bange FC, de Roux A, Pletz MW, Rademacher J, Suhling H, Wagner D, Welte T. Burden and trends of hospitalisations associated with pulmonary non-tuberculous mycobacterial infections in Germany, 2005-2011. BMC Infect Dis 13 (2013) 231.

Hoefsloot W, van Ingen J, Andrejak C, Ängeby K, Bauriaud R, Bemer P, Beylis N, Boeree MJ, Cacho J, Chihota V, Chimara E, Churchyard G, Cias R, Dasa R, Daley CL, Dekhuijzen PNR, Domingo D, Drobniewski F, Esteban J, Fauville-Dufaux M, Folkvardsen DB, Gibbons N, Gómez-Mampaso E, Gonzalez R, Hoffmann H, Hsueh PR, Indra A, Jagielski T, Jamieson F, Jankovic M, Jong E, Keane J, Koh WJ, Lange B, Leao S, Macedo R, Mannsåker T, Marras TK, Maugein J, Milburn HJ, Mlinkó T, Morcillo N, Morimoto K, Papaventsis D, Palenque E, Paez-Peña M, Piersimoni C, Polanová M, Rastogi N, Richter E, Ruiz-Serrano MJ, Silva A, da Silva MP, Simsek H, van Soolingen D, Szabó N, Thomson R, Tórtola Fernandez MT, Tortoli E, Totten SE, Tyrrell G, Vasankari T, Villar M, Walkiewicz R, Winthrop K, Wagner D, for NTM-NET 2012. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study. Eur Resp J 42 (2013) 1604-13.

Kern WV, Marchetti O, Drgona L, Akan H, Aoun M, Akova M, de Bock R, Paesmans M, Viscoli C, Calandra T, and the EORTC-IDG Trial XV Investigators. Oral antibiotics for fever in low-risk neutropenic cancer patients: a double-blind, randomized, multicenter trial comparing single daily moxifloxacin with twice daily ciprofloxacin plus amoxicillin/clavulanic acid combination therapy (European Organization for Research and Treatment of Cancer protocol 46001, Infectious Diseases Group trial XV). J Clin Oncol 31 (2013) 1149-56.

van der Linden M, Reinert RR, Kern WV, Imöhl M. Epidemiology of serotype 19A isolates from invasive pneumococcal disease in German children. BMC Infect Dis 13 (2013) 70.

Goessweiner-Mohr N, Grumet L, Pavkov-Keller T, Birner-Gruenberger R, Grohmann E, Keller W. Crystallization and preliminary structure determination of the transfer protein TraM from the Gram-positive conjugative plasmid pIP501. Acta Crystallogr Sect F Struct Biol Cryst Commun 69 (2013) 178-83

Goessweiner-Mohr N, Grumet L, Arends K, Pavkov-Keller T, Gruber CC, Gruber K, Birner-Gruenberger R, Kropec-Huebner A, Huebner J, Grohmann E, Keller W. The 2.5 A structure of the Enterococcus conjugation protein TraM resembles VirB8 type IV secretion proteins. J Biol Chem 288 (2013) 2018-28.

Stete K, Krauth SJ, Coulibaly JT, Knopp S, Hattendorf J, Müller I, Lohourignon LK, Kern WV, N'goran EK, Utzinger J. Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children. Parasit Vectors 5 (2012) 298.

Sakinc T, Baars B, Wüppenhorst N, Kist M, Huebner J, Opferkuch W. Influence of a 23S ribosomal RNA mutation in Helicobacter pylori strains on the in vitro synergistic effect of clarithromycin and amoxicillin. BMC Res Notes 5 (2012) 603.

Borde JP, Meier S, Fingerle V, Klier C, Huebner J, Kern WV. CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings. BMC Infect Dis 12 (2012) 344.

Goessweiner-Mohr N, Fercher C, Abajy MY, Grohmann E, Keller W. Crystallization and first data collection of the putative transfer protein TraN from the Gram-positive conjugative plasmid pIP501. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (2012) 1402-5.

King NP, Sakinç T, Ben Zakour NL, Totsika M, Heras B, Simerska P, Shepherd M, Gatermann SG, Beatson SA, Schembri MA. Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance. BMC Microbiol 12 (2012) 8.

Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H; ESAC-3 Hospital Care Subproject Group. Antimicrobial prescribing in hospitalized adults stratified by age: data from the ESAC point-prevalence surveys. Drugs Aging 29 (2012) 53-62.

Dalkmann P, Broszat M, Siebe C, Willaschek E, Sakinc T, Huebner J, Amelung W, Grohmann E, Siemens J. Accumulation of  pharmaceuticals, enterococcus, and resistance genes in soils irrigated with wastewater for zero to 100 years in central Mexico. PLoS One 7 (2012) e45397.

Geiss-Liebisch S, Rooijakkers SH, Beczala A, Sanchez-Carballo P, Kruszynska K, Repp C, Sakinc T, Vinogradov E, Holst O, Huebner J, Theilacker C. Secondary cell wall polymers of Enterococcus faecalis are critical for resistance to complement activation via mannose-binding lectin. J Biol Chem 287 (2012) 37769-77.

Bouchaud O, Mühlberger N, Parola P, Calleri G, Matteelli A, Peyerl-Hoffmann G, Méchaï F, Gautret P, Clerinx J, Kremsner PG, Jelinek T, Kaiser A, Beltrame A, Schmid ML, Kern P, Probst M, Bartoloni A, Weinke T, Grobusch MP. Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study. Malar J 11 (2012) 212.

Skurnik D, Kropec A, Roux D, Theilacker C, Huebner J, Pier GB. Natural antibodies in normal human sera inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy. Clin Infect Dis 55 (2012)1188-97.

Anjum R, Grohmann E, Malik A. Exogenous isolation of conjugative plasmids from pesticide contaminated soil. World J Microbiol Biotechnol 28 (2012) 567-74.

Bao Y, Sakinc T, Laverde D, Wobser D, Benachour A, Theilacker C, Hartke A, Huebner J. Role of mprF1 and mprF2 in the pathogenicity of Enterococcus faecalis. PLoS One 7 (2012) e38458.

Buyle F, Metz-Gercek S, Mechtler R, Kern WV, Robays H, Vogelaers D, Struelens M. Prospective multicentre feasibility study of a quality of care indicator for intravenous to oral switch therapy with highly bioavailable antibiotics. J Antimicrob Chemother 67(8):2043-6.

Hogendorf WF, Kropec A, Filippov DV, Overkleeft HS, Huebner J, van der Marel GA, Codée JD. Light fluorous synthesis of glucosylated glycerol teichoic acids. Carbohydr Res 356 (2012) 142-51 .

Theilacker C, Holst O, Lindner B, Huebner J, Kaczyński Z. The structure of the wall teichoic acid isolated from Enterococcus faecalis strain 12030. Carbohydr Res 354 (2012) 106-9.

Lange B, Vavra M, Kern WV, Wagner D. Development of tuberculosis in immunocompromised patients with a positive tuberculosis-specific IGRA. Int J Tuberc Lung Dis 16 (2012) 492-5.

Eicher T, Cha HJ, Seeger MA, Brandstätter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grütter MG, Diederichs K, Pos KM. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. PNAS 109 (2012) 5687-92.

Arends K, Schiwon K, Sakinc T, Hübner J, Grohmann E. Green fluorescent protein-labeled monitoring tool to quantify conjugative plasmid transfer between Gram-positive and Gram-negative bacteria. Appl Environ Microbiol 78 (2012) 895-9.

Theilacker C, Kropec A, Hammer F, Sava I, Wobser D, Sakinc T, Codée JDC, Hogendorf WFJ, van der Marel GA Huebner J. Protection against Staphylococcus aureus by antibody to the polyglycerolphosphate backbone of heterologous lipoteichoic acid. J Infect Dis 205 (2012) 1076-85.

Thoden J, Rieg SR, Venhoff N, Wennekes V, Schmitt-Graeff A, Wagner D, Kern WV. Fatal hemophagocytic syndrome in a patient with a previously well-controlled asymptomatic HIV infection after EBV reactivation. J Infect 64 (2012) 110-2.

Hofmann SC, Saborowski V, Lange S, Kern WV, Bruckner-Tuderman L, Rieg SR. Expression of innate defence antimicrobial peptides in hidradenitis suppurativa. J Am Acad Dermatol 66 (2012) 966-74.

Rigottier-Gois L, Alberti A, Houel A, Taly JF, Palcy P, Manson J, Pinto D, Matos RC, Carrilero L, Montero N, Tariq M, Karsens H, Repp C, Kropec A, Budin-Verneuil A, Benachour A, Sauvageot N, Bizzini A, Gilmore MS, Bessières P, Kok J, Huebner J, Lopes F, Gonzalez-Zorn B, Hartke A, Serror P. Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelope fitness factors. PLoS One 6 (2011) e29023.

Bychowska A, Theilacker C, Czerwicka M, Marszewska K, Huebner J, Holst O, Stepnowski P, Kaczyński Z. Chemical structure of wall teichoic acid isolated from Enterococcus faecium strain U0317. Carbohydr Res 346 (2011): 2816-9.

Balabanova Y, Gilsdorf A, Buda S, Burger R, Eckmanns T, Gärtner B, Groß U, Haas W, Hamouda O, Hübner J, Jänisch T, Kist M, Kramer MH, Ledig T, Mielke M, Pulz M, Stark K, Suttorp N, Ulbrich U, Wichmann O, Krause G. Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. PLoS One 6 (2011) e25691.

Kropec A, Sava IG, Vonend C, Sakinc T, Grohmann E, Huebner J. Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections. Microbiology 157 (2011) 3429-34.

Hogendorf WF, Meeuwenoord N, Overkleeft HS, Filippov DV, Laverde D, Kropec A, Huebner J, Van der Marel GA, Codée JD. Automated solid phase synthesis of teichoic acids. Chem Commun (Camb) 47 (2011) 8961-3.

Laverde Gomez JA, Hendrickx AP, Willems RJ, Top J, Sava I, Huebner J, Witte W, Werner G. Intra- and interspecies genomic transfer of the Enterococcus faecalis pathogenicity island. PLoS One 6 (2011) e16720.

Becker SL, Sieto B, Silué KD, Adjossan L, Koné S, Hatz C, Kern WV, N’Goran EK, Utzinger J. Diagnosis, clinical features, and self-reported morbidity of Strongyloides stercoralis and hookworm infection in a co-endemic setting. PLoS Negl Dis 5 (2011) e1292.

Anjum R, Grohmann E, Malik A. Molecular characterization of conjugative plasmids in pesticide tolerant and multi-resistant bacterial isolates from contaminated alluvial soil. Chemosphere 84 (2011) 175-81.

Steffens B, Kümmerle T, Koch S, Birtel A, Schwarze-Zander C, Emmelkamp J, Kern WV, Hertenstein C, Wyen C, Lehmann C, Cornely OA, Rockstroh J, Fätkenheuer G. Acceptance and tolerability of an adjuvanted nH1N1 vaccine in HIV-infected patients in the Cologne-Bonn cohort. Eur J Med Res 16 (2011) 289-94.

Bohnert J, Szymaniak-Vits M, Schuster S, Kern WV. Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli. J Antimicrob Chemother 66 (2011) 2057-60.

Geyer M, Wilpert J, Wiech T, Theilacker C, Stubanus M, Kramer-Zucker A, Fischer KG, Drognitz O, Frydrychowicz A, Kern W, Walz G, Pisarski P. Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient. Transpl Infect Dis 13 (2011) 278-84.

Held J, Wagner D. β-D-Glucan kinetics for the assessment of treatment response in P. jirovecii pneumonia. Clin Microbiol Infec 17 (2011) 1118-22.

Rieg S, Schmoldt S, Theilacker C, de With K, Wolfel S, Kern WV, Dobler G. Tick-borne lymphadenopathy (TIBOLA) acquired in Southwestern Germany. BMC Infectious Diseases 11(2011) 167.

Bohnert J, Szymaniak-Vits M, Schuster S, Kern WV. Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2´-dinaphthylamine efflux assay. PLoS One 6 (2011) e21196.

Brandstätter L, Sokolova L, Eicher T, Seeger MA, Briand C, Cha HJ, Cernescu M, Bohnert J, Kern WV, Brutschy B, Pos KM. Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS. Biochim Biophys Acta 1808 (2011) 2189-96.

Kaasch AJ, Fowler VGJr, Rieg S, Peyerl-Hoffmann G, Birkholz H, Hellmich M, Kern WV, Seifert H. Use of a simple criteria set for guiding echocardiography in nosocomial Staphylococcus aureus bacteremia. Clin Infect Dis 53 (2011) 1-9.

Becker SL, Lohourignon LK, Speich B, Rinaldi L, Knopp S, N’Goran EK, Cringoli G, Utzinger J. Comparison of the FLOTAC-400 dual technique and the formalin-ether concentration technique for the diagnosis of human intestinal protozoa infection. J Clin Microbiol 49 (2011) 2183-90.

Rieg SR, Kaasch AJ, Wehrle J, Hofmann SC, Szymaniak-Vits M, Saborowski V, Jonas D, Kalbacher H, Seifert H, Kern WV. Susceptibility of clinical Staphylococcus aureus isolates to innate defense antimicrobial peptides. Microbes Infect 13 (2011) 761-5.

Ness T, Kern WV, Frank U, Reinhard T. Postoperative nosocomial endophthalmitis: is perioperative antibiotic prophylaxis advisable? A single centre's experience. J Hosp Infect 78 (2011) 138-42.

Theilacker C, Sava I, Sanchez-Carballo P, Bao Y, Kropec A, Grohmann E, Holst O, Huebner J. Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation. BMC Microbiol 11(2011) 67.

Theilacker C, Kaczyński Z, Kropec A, Sava I, Ye L, Bychowska A, Holst O, Huebner J. Serodiversity of opsonic antibodies against Enterococcus faecalis -glycans of the cell wall revisited. PLoS One 6 (2011) e17839.

Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H, on behalf of the ESAC-3 hospital care subproject group. Identification of targets for quality improvement in antimicrobial prescribing: the web-based ESAC Point Prevalence Survey 2009. J Antimicrob Chemother 66 (2011) 443-9.

2010

Al-Ahmad A, Maier J, Follo M, Spitzmüller B, Wittmer A, Hellwig E, Hübner J, Jonas D. Food-borne enterococci integrate into oral biofilm: an in vivo study. J Endod 36 (2010) 1812-9.

Hanin A, Sava I, Bao Y, Huebner J, Hartke A, Auffray Y, Sauvageot N. Screening of in vivo activated genes in Enterococcus faecalis during insect and mouse infections and growth in urine. PLoS One 5 (2010) e11879.

Sava IG, Heikens E, Kropec AP, Theilacker C, Willems R, Huebner J. Enterococcal surface protein contributes to persistance in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection. J Med Microbiol 59 (2010) 1001-4.

Hoffmeister B, Peyerl-Hoffmann G, Pischke S, Zollner-Schwetz I, Krause R, Mueller M, Graf A, Kluge S, Burchard GD, Kern WV, Suttorp N, Cramer JP. Differences in clinical manifestations of imported versus autochthonous leptospirosis in Austria and Germany. Am J Trop Med Hyg 83 (2010) 326-35.

Jha S, Danelishvili L, Wagner D, Maser J, Li Y, Moric I, Vogt S, Yamazaki Y, Lai B, Bermudez L. Virulence-related Mycobacterium avium MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol 10 (2010) 100.

Lange B, Vavra M, Kern WV, Wagner D. Indeterminate results of a tuberculosis-specific interferon-γ release assay in immunocompromised patients. Eur Resp J 35 (2010) 1179-82.

Gening ML, Maira-Litrán T, Kropec A, Skurnik D, Grout M, Tsvetkov YE, Nifantiev NE, Pier GB. Synthetic {beta}-(1->6)-linked N-acetylated and nonacetylated oligoglucosamines used to produce conjugate vaccines for bacterial pathogens. Infect Immun 78 (2010) 764-72.

Rieg SR, Bauer TM, Peyerl-Hoffmann G, Held J, Ritter W, Wagner D , Kern WV, Serr A. Paenibacillus larvae bacteremia in injection drug users. Emerg Infect Dis 16 (2010) 487-9.

Rieg SR, Meier B, Fähnrich E, Huth A, Wagner D, Kern WV, Kalbacher H. Differential activity of innate defense antimicrobial peptides  against Nocardia species. BMC Microbiol 10 (2010) 61.

Li YJ, Danelishvili L, Wagner D, Petrofsky M, Bermudez LE. Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms. J Med Microbiol 59 (2010) 8-16.

 

2009

Zarb P, Amadeo B, Muller A, Drapier N, Vankerckhoven V, Davey P, Goossens H; on behalf of the ESAC-3 hospital care subproject group. Identification of targets for quality improvement in antimicrobial prescribing: the web-based ESAC Point Prevalence Survey 2009. J Antimicrob Chemother 65 (2010) 2247-52.

Martins A, Iversenc C, Rodrigues L, Spengler G, Ramosa J, Kern WV, Couto I, Viveiros M, Fanning S, Pagès JM, Amaral L. AcrAB mediated MDR phenotype is maintained after efflux pump genes and their two regulators have restored wild type activities. Int J Antimicrob Agents 34 (2009) 602-4.

Rodrigues L, Sampaio D, Couto I, Machado D, Kern WV, Amaral L, Viveiros M. The role played by efflux pumps in macrolide resistance in Mycobacterium avium complex. Int J Antimicrob Agents 34 (2009) 529-33.

Rieg SR, Peyerl-Hoffmann G, de With K, Theilacker C, Wagner D, Hübner J, Dettenkofer M, Kaasch A, Seifert H, Schneider C, Kern WV. Mortality of Staphylococcus aureus bacteremia and infectious diseases specialist consultation – a study of 521 patients in Germany. J Infect 59 (2009) 232-9.

Theilacker C, Jonas D, Huebner J, Bertz H, Kern WV. Outcomes of invasive infection due to vancomycin-resistant Enterococcus faecium during a recent outbreak. Infection 37 (2009) 540-3.

Creti R, Fabretti F, Koch S, Huebner J, Garsin DA, Baldassarri L, Montanaro L, Arciola CR. Surface protein EF3314 contributes to virulence properties of Enterococcus faecalis. Int J Artif Organs 32 (2009) 611-20.

Reuter S, Kern WV, Zenz C, Kern P. Prognostic factors for invasive aspergillosis in patients with haematological malignancies. Scand J Infect Dis 41 (2009) 483-90.

de With K, Bestehorn H, Steib-Bauert M, Kern WV. Comparison of defined versus recommended versus prescribed daily doses for measuring hospital antibiotic consumption. Infection 37 (2009) 349-52.

Sava IG, Zhang F, Toma I, Theilacker C, Li B, Baumert TF, Holst O, Linhardt RJ, Huebner J. Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells. J Biol Chem 284 (2009) 18194-201.

Theilacker C, Sanchez-Carballo P, Toma I, Fabretti F, Sava I, Kropec A, Holst O, Huebner J. Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis. Mol Microbiol 71 (2009) 1055-69.

Ammerlaan H, Seifert H, Harbarth S, Brun-Buisson C, Torres A, Antonelli M, Kluytmans J, Bonten M; European Practices of Infections with Staphylococcus aureus (SEPIA) Study Group. Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. Clin Infect Dis 49 (2009) 997-1005.

Coenen S, Muller A, Adriaenssens N, Vankerckhoven V, Hendrickx E, Goossens H; ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC). Outpatient parenteral antibiotic treatment in Europe. J Antimicrob Chemother 64 (2009) 200-5.

Rieg S, Huth A, Kalbacher H, Kern WV. Resistance against antimicrobial peptides is independent of Escherichia coli AcrAB, Pseudomonas aeruginosa MexAB and Staphylococcus aureus NorA efflux pumps. Int J Antimicrob Agents 33 (2009) 174-6.

Wehmeier C, Schuster S, Fähnrich E, Kern WV, Bohnert JA. Site-directed mutagenesis reveals amino acid residues in the Escherichia coli RND efflux pump AcrB that confer macrolide resistance. Antimicrob Agents Chemother 53 (2009) 329-30.

 

2008

van de Sande-Bruinsma N, Grundmann H, Verloo D, Tiemersma E, Monen J, Goossens H, Ferech M; European Antimicrobial Resistance Surveillance System Group; European Surveillance of Antimicrobial Consumption Project Group. Antimicrobial drug use and resistance in Europe. Emerg Infect Dis 14 (2008) 1722-30.

Wolkewitz M, Dettenkofer M, Bertz H, Schumacher M, Huebner J. Statistical epidemic modeling with hospital outbreak data. Stat Med 27 (2008) 6522-31.

Bohnert JA, Schuster S, Seeger MA, Fähnrich E, Pos KM, Kern WV. Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB. J Bacteriol 190 (2008) 8225-9.

Henneke P, Dramsi S, Mancuso G, Chraibi K, Pellegrini E, Theilacker C, Hübner J, Santos-Sierra S, Teti G, Golenbock DT, Poyart C, Trieu-Cuot P. Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis. J Immunol 180 (2008) 6149-58.

Arnold C, von Sanden S, Theilacker C, Blum HE. [Ulcerous colitis and infection with cytomegalovirus, herpes simplex virus and clostridium difficile] Z Gastroenterol 46 (2008) 780-3.

Kern WV, Steib-Bauert M, Amann S, Fellhauer M, de With K. Hospital antibiotic management in Germany – results of the ABS maturity survey of the ABS International group. Wiener Klin Wochenschr 120 (2008) 294-8.

Viveiros M, Martins A, Paixao L, Rodrigues L, Martins M, Couto I, Fähnrich E, Kern WV, Amaral L. Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium brmide method. Int J Antimicrob Agents 31 (2008) 458-62.

Linder K, Zia M, Kern WV, Pfau RKM, Wagner D. Relapses vs. reactions in multibacillary leprosy: proposal of new relapse criteria. Trop Med Intern Health 13 (2008) 295-309.

Rodrigues L, Wagner D, Viveiros M, Sampaio D, Couto I, Vavra M, Kern WV, Amaral L. Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis. J Antimicrob Chemother 61 (2008) 1076-82.

Seifert H, Wisplinghoff H, Kaasch A, Achilles K, Langhorst A, Peyerl-Hoffmann G, Woehrmann A, Fätkenheuer G, Salzberger B, Kern WV. [Epidemiology, course and prognosis of Staphylococcus aureus bacteremia--Preliminary results from the INSTINCT (INvasive STaphylococcus aureus INfection CohorT) cohort]. Dtsch Med Wochenschr 133 (2008) 340-5.

Arciola CR, Baldassarri L, Campoccia D, Creti R, Pirini V, Huebner J, Montanaro L. Strong biofilm production, antibiotic multi-resistance and high gelE expression in epidemic clones of Enterococcus faecalis from orthopaedic implant infections. Biomaterials 29 (2008) 580-6.

 

2007

Arciola CR, Campoccia D, Baldassarri L, Pirini V, Huebner J, Montanaro L. The role of Enterococcus faecalis in orthopaedic peri-implant infections demonstrated by automated ribotyping and cluster analysis. Biomaterials 28 (2007) 3987-95.

Schumacher A, Trittler R, Bohnert JA, Kümmerer K, Pagès JM, Kern WV. Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation. J Antimicrob Chemother 59 (2007) 1261-64.

Bohnert JA, Schuster S, Fähnrich E, Trittler R, Kern WV. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND type MDR efflux pump YhiV (MdtF). J Antimicrob Chemother 59 (2007) 1216-22.

Gabelmann A, Klein S, Kern WV, Krüger S, Brambs HJ, Rieber-Brambs A, Pauls S. Relevant imaging findings of cerebral aspergillosis on MRI: a retrospective case-based study in immunocompromised patients. Eur J Neurol 14 (2007) 548-55.

Wichmann O, Gascon J, Schunk M, Puente S, Siikamaki H, Gjørup I, Lopez-Velez R, Clerinx J, Peyerl-Hoffmann G, Sundøy A, Genton B, Kern P, Calleri G, de Górgolas M, Mühlberger N, Jelinek T; European Network on Surveillance of Imported Infectious Diseases. Severe dengue virus infection in travelers: risk factors and laboratory indicators. J Infect Dis 195 (2007) 1089-96.

Coenen S, Ferech M, Haaijer-Ruskamp FM, Butler CC, Vander Stichele RH, Verheij TJ, Monnet DL, Little P, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): quality indicators for outpatient antibiotic use in Europe. Qual Saf Health Care 16 (2007) 440-5.

Muller A, Coenen S, Monnet DL, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe, 1998-2005. Euro Surveill 12 (2007) E071011.1

Goossens H, Ferech M, Coenen S, Stephens P, ESAC Project Group. Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries. Clin Infect Dis 44 (2007) 1091-5. Erratum in: Clin Infect Dis 44 (2007) 1259.

 

2006

Theilacker C, Kacynski Z, Kropec A, Fabretti F, Sange T, Holst O, Huebner J. Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid. Infect Immun 74 (2006) 5703-12.

Kern WV, de With K, Nink K, Steib-Bauert M, Schröder H. Regional variation in outpatient antibiotic prescribing in Germany. Infection 34 (2006) 269-73.

de With K, Steib-Bauert M, Straach P, Kern WV. Is there significant regional variation in hospital antibiotic consumption in Germany? Infection 34 (2006) 274-7.

Ferech M, Coenen S, Malhotra-Kumar S, Dvorakova K, Hendrickx E, Suetens C, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient quinolone use in Europe. J Antimicrob Chemother 58 (2006) 423-7.

Coenen S, Ferech M, Malhotra-Kumar S, Hendrickx E, Suetens C, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe. J Antimicrob Chemother  58 (2006) 418-22.

Coenen S, Ferech M, Dvorakova K, Hendrickx E, Suetens C, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient cephalosporin use in Europe. J Antimicrob Chemother 58 (2006) 413-7.

Ferech M, Coenen S, Dvorakova K, Hendrickx E, Suetens C, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient penicillin use in Europe. J Antimicrob Chemother 58 (2006) 408-12.

Ferech M, Coenen S, Malhotra-Kumar S, Dvorakova K, Hendrickx E, Suetens C, Goossens H, ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe. J Antimicrob Chemother 58 (2006) 401-7.

Meyer-Koenig U, Romberg I, Schneider K, Weidmann M, Kern WV, Hufert FT. Diagnostic value of cytomegalovirus pp67 RT-PCR in solid organ transplant recipients. J Clin Microbiol 44 (2006) 3394-6.

de With K, Meyer E, Steib-Bauert M, Schwab F, Daschner FD, Kern WV. Antibiotic use in two cohorts of German intensive care units, 2001-2002. J Hosp Infect 64 (2006) 231-7.

von Baum H, Sigge A, Bommer M, Kern WV, Marre R, Doehner H, Kern P, Reuter S. Moxifloxacin prophylaxis in neutropenic patients. J  Antimicrob Chemother 58 (2006) 891-4.

Hsu CT, Ganong AL, Reinap B, Mourelatos Z, Huebner J, Wang J. Immunochemical characterization of polysaccharide antigens from six clinical strains of enterococci. BMC Microbiol 6 (2006) 62.

Creti R, Koch S, Fabretti F, Baldassarri L, Huebner J. Enterococcal colonization of the gastro-intestinal tract: role of biofilm and environmental oligosaccharides. BMC Microbiol 6 (2006) 60.

Fabretti F, Theilacker C, Baldassarri L, Kaczynski Z, Kropec A, Holst O, Huebner J. Alanine esters of enterococcal lipoteichoic acid play a role in biofilm formation and resistance to antimicrobial peptides. Infect Immun 74 (2006) 4164-71.

Fang X, Zeisel MB, Wilpert J, Gissler B, Thimme R, Kreutz C, Maiwald T, Timmer J, Kern WV, Donauer J, Geyer M, Walz G, Depla E, von Weizsäcker F, Blum HE, Baumert TF. Host cell responses induced by hepatitis C virus binding. Hepatology 43 (2006) 1326-36.

Huck B, Egger M, Bertz H, Peyerl-Hoffmann G, Kern WV, Neumann-Haefelin D, Falcone V. Human metapneumovirus (HMPV) infection in a hematopoietic stem cell transplant recipient with relapsed multiple myeloma and rapidly progressing lung cancer. J Clin Microbiol 44 (2006) 2300-3.

de With K, Maier L, Steib-Bauert M, Kern P, Kern WV. Trends in antibiotic use at a university hospital: defined or prescribed daily doses, patient days or admissions as denominator? Infection 34 (2006) 91-4.

Wagner D, Maser J, Moric I, Vogt S, Kern WV, Bermudez LE. Elemental analysis of the Mycobacterium avium–containing phagosomes in macrophages from Balb/c mice. Biochem Biophys Res Comm 344 (2006) 1346-51.

Pannek S, Higgins PG, Steinke P, Jonas D, Akova M, Bohnert JA, Seifert H, Kern WV. Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginin-ß-naphthylamide. J Antimicrob Chemother 57 (2006) 970-4.

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J. Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites. Infection 34 (2006) 1-4.

Kern WV, Steinke P, Schumacher A, Schuster S, von Baum H, Bohnert JA. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J Antimicrob Chemother 57 (2006) 339-43.

Schuhmacher A, Steinke P, Bohnert JA, Akova  M, Jonas D, Steib-Bauert M, de With K, Reuter S, Bertz H, Frank U, Kern WV.  Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than E. coli. J Antimicrob Chemother 57 (2006) 344-8.

Jansen JP, Kern WV, Cornely OA, Karthaus M, Ruhnke M, Ullmann AJ, Resch A. Economic evaluation of voriconazole versus conventional amphotericin B in the treatment of invasive aspergillosis in Germany. Value Health 9 (2006) 12-23.

Viscoli C, Cometta A, Kern WV, Bock R, Paesmans M, Crokaert F, Glauser MP, Calandra T; International Antimicrobial Therapy Group of the EORTC. Piperacillin-tazobactam monotherapy in high-risk febrile and neutropenic cancer patients. Clin Microbiol Infect 12 (2006) 212-6.

 

2005

Kern WV, Steib-Bauert M, de With K, Reuter S, Bertz H, Frank U, von Baum H. Fluoroquinolone consumption and resistance in haematology-oncology patients – ecological analysis in two university hospitals 1999-2002. J Antimicrob Chemother 55 (2005) 57-60.

Wagner D, Maser J, Lai B, Cai Z, Barry CE, Höner zu Bentrup K, Russell DG, Bermudez LE. Elemental analysis of  Mycobacterium avium, Mycobacterium tuberculosis and Mycobacterium smegmatis – containing phagosomes indicates pathogen-induced microenvironments within the host cell’s endosomal system. J Immunol 174 (2005) 1491-500.

Bohnert J, Kern WV. Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Antimicrob Agents Chemother 49 (2005) 849-52.

Goossens H, Ferech M, Vander Stichele RH, Elseviers M, and the ESAC Project Group. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 365 (2005) 579-87.

Kern WV, Klose K, Jellen-Ritter AS, Oethinger M, Bohnert J, Kern P, Reuter S, von Baum H, Marre R. Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenuc patients with leukemia. Eur J Clin Microbiol Infect Dis 24 (2005) 111-8.

de With K, Steib-Bauert M, Knoth H, Dörje F, Strehl E, Rothe U, Maier L, Kern WV. Hospital use of systemic antifungal drugs. BMC Clin Pharmacol 5 (2005) 1.

Reuter S, Kern WV, Sigge A, Döhner H, Marre R, Kern P, von Baum H. Impact of fluoroquinolone prophylaxis on reduced infection-related mortality in neutropenic patients with hematologic malignancies. Clin Infect Dis 40 (2005) 1087-93.

Wagner D, Sangari FJ, Parker A, Bermudez LE. fecB, a gene potentially involved in iron transport in Mycobacterium avium, is not induced within macrophages. FEMS Microbiol Letters 247 (2005) 185-91.

Weitzel T, Muhlberger N, Jelinek T, Schunk M, Ehrhardt S, Bogdan C, Arasteh K, Schneider T, Kern WV, Fatkenheuer G, Boecken G, Zoller T, Probst M, Peters M, Weinke T, Gfrorer S, Klinker H, Holthoff-Stich ML; SIMPID Network. Imported leishmaniasis in Germany 2001-2004: data of the SIMPID surveillance network. Eur J Clin Microbiol Infect Dis 24 (2005) 471-6.

Maira-Litran T, Kropec A, Goldmann DA, Pier GB. Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine. Infect Immun 73 (2005) 6752-62.

Kropec A, Maira-Litran T, Jefferson KK, Grout M, Cramton SE, Gotz F, Goldmann DA, Pier GB. Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infect Immun 73 (2005) 6868-76.

Hufnagel M, Kropec A, Theilacker C, Huebner J. Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in healthy human sera. Clin Diagn Lab Immunol 12 (2005) 930-4.

Baldassarri L, Bertuccini L, Creti R, Filippini P, Ammendolia MG, Koch S, Huebner J, Orefici G. Glycosaminoglycans mediate invasion and survival of Enterococcus faecalis into macrophages. J Infect Dis 191 (2005) 1253-62.

Wagner D, Sander A, Bertz H, Finke J, Kern WV. Breakthrough invasive infection due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a stem cell transplant patient receiving liposomal amphotericin B and caspofungin for suspected aspergillosis. Infection 33 (2005) 397-400.

Kern WV, de With K, Steib-Bauert M, Fellhauer M, Plangger A, Probst W, and the MABUSE-INTERREGIO-II project team. Antibiotic use in non-university regional acute care general hospitals in southwestern Germany, 2001-2002. Infection 33 (2005) 333-9.

Engel A, Knoll SA, Kern P, Kern WV. Interleukin-8 serum levels at fever onset in patients with neutropenia predict early medical complications. Infection 33 (2005) 380-382.

Hufnagel M, Huebner J. Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections. Infection 33 (2005) 373-6.

Kropec A, Hufnagel M, Zimmermann K, Huebner J. in vitro assessment of the host response against Enterococcus faecalis used in probiotic preparations. Infection 33 (2005) 377-9.

Gascon J, Mayor A, Muhlberger N, Peyerl-Hoffmann G, Oliveira I, Dobano C, Jelinek T, Corachan M. [Molecular epidemiological surveillance of markers for antimalarial drugs in Plasmodium falciparum isolates imported to Barcelona, Spain] Med Clin (Barc) 125 (2005) 286-9.

2004

Buchheidt D, Hummel M, Schleiermacher D, Spiess B, Schwerdtfeger R, Cornely OA, Wilhelm S, Reuter S, Kern WV, Südhoff T, Mörz H, Hehlmann R. Prospective clinical evaluation of a LightCycler-mediated polymerase chain reaction assay, a nested-PCR assay and a galactomannan enzyme-linked immunosorbent assay for detection of invasive aspergillosis in neutropenic cancer patients and haematological stem cell transplant recipients. Br J Haematol 125 (2004) 196-202.

de With K, Bergner J, Bühner R, Dörje F, Gonnermann C, Haber M, Hartmann M, Rothe U, Strehl E, Steib-Bauert M, Kern WV. Antibiotikaanwendung an deutschen Hochschulkliniken (Projekt INTERUNI-II). Ergebnisse für medizinische Kliniken unter Berücksichtigung von Intensivpflegestationen, onkologischen Stationen und sonstigen Pflegebereichen. Med Klin 99 (2004) 347-54.

de With K, Bergner J, Bühner R, Dörje F, Gonnermann C, Haber M, Hartmann M, Rothe U, Strehl E, Steib-Bauert M, Kern WV. Antibiotic use in German university hospitals 1998-2000 (project INTERUNI-II). Int J Antimicrob Agents 24 (2004) 213-8.

Harder J, Riecken B, Walter E, Ihling K, Bauer TM. Hepatitis C virus infection in intravenous drug users. Clin Microbiol Infect (2004) 768-70.

McGarvey JA, Wagner D, Bermudez LE. Differential gene expression in mononuclear phagocytes infected with pathogenic and non-pathogenic mycobacteria. Clin Exp Immunol 136 (2004) 490-500.

Kern WV, de With K, Gonnermann C, Strehl E, and the MABUSE-INTERUNI-II project team. Update on glycopeptide use in German university hospitals. Infection 32 (2004) 157-62.

Wagner D, de With K, Huzly D, Hufert F, Weidmann M, Breisinger S, Eppinger S, Kern WV, Bauer TM. Nosocomial acquisition of Dengue. Emerg Infect Dis 10 (2004) 1872-3.

Kern WV, de With K. Antibiotikaanwendung auf chirurgischen und internistischen Intensivstationen von Universitätskliniken – Ergebnisse des Projekts INTERUNI-II. Krankenhaushygiene + Infektionsverhütung 26 (2004) 215-7.

vander Stichele RH, Elseviers M, Ferech M, Blot S, Goossens H, and the ESAC Project Group. European Surveillance of Antimicrobial Consumption (ESAC): data collection performance and methodological approach. Br J Clin Pharmacol 58 (2004) 1-10.

de With K, Steib-Bauert M, Bergner J, Bühner R, Dörje F, Gonnermann C, Haber M, Hartmann M, Rothe U, Strehl E, Daschner FD, Kern WV. Antibiotikaanwendung an chirurgischen Universitätskliniken (Projekt INTERUNI-II). Krankenhauspharmazie 25 (2004) 478-83.

Wichmann O, Muehlberger N, Jelinek T, Alifrangis M, Peyerl-Hoffmann G, Muhlen M, Grobusch MP, Gascon J, Matteelli A, Laferl H, Bisoffi Z, Ehrhardt S, Cuadros J, Hatz C, Gjorup I, McWhinney P, Beran J, da Cunha S, Schulze M, Kollaritsch H, Kern P, Fry G, Richter J; European Network on Surveillance of Imported Infectious Diseases. Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe. J Infect Dis 190 (2004) 1541-6.

 

2003

Cometta A, Kern WV, De Bock R, Paesmans B, Vandenbergh M, Marchetti O, Akan H, Vandercam B, Skoutelis A, Akova M, Korten V, Crokaert F, Engelhard D, Gaya H, Padmos A, Calandra T, Klasresky J, Zinner S, Glauser M, Viscoli C, for the EORTC International Antimicrobial Therapy Group: Vancomycin versus placebo for persistent fever in neutropenic cancer patients given piperacillin/tazobactam monotherapy: an EORTC-IATG multicenter, double blind, placebo-controlled trial. Clin Infect Dis (2003) 328-89.

Wellinghausen N, Kern WV, Haase G, Rozdzinski E, Kern P, Marre R, Essig A, Hetzel J, Hetzel M. A farmer with recurrent fever and bilateral pulmonary infiltrates. Int J Med Microbiol 293 (2003) 441-5.

 

2002

Bauer TM, Fernandez J, Navasa M, Vila J, Rodes J. Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis. J Hepatol 36 (2002) 501-6.

Bauer TM, Follo A, Navasa M, Vila J, Planas R, Clemente G, Vargas V, Bory F, Vaquer P, Rodes J. Daily norfloxacin is more effective than weekly rufloxacin in prevention of spontaneous bacterial peritonitis recurrence. Dig Dis Sci 47 (2002) 1356-61.

Bauer TM, Schwacha H, Steinbruckner B, Brinkmann FE, Ditzen AK, Aponte JJ, Pelz K, Berger D, Kist M, Blum HE. Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia. Am J Gastroenterol 97 (2002) 2364-70.

Broxmeyer L, Sosnowska D, Miltner E, Chacon O, Wagner D, McGarvey J, Barletta RG, Bermudez LE. Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogens. J Infect Dis 186 (2002) 1155-60.

Herbrecht R, Denning DW, Patterson TF, Bennett Je, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, De Pauw B. Randomized comparison of voriconazole and amphotericin B in primary therapy of invasive aspergillosis. N Engl J Med 347 (2002) 408-15.

Kern WV, de With K, Trautmann M, Kern P, Gonnermann C. Glycopeptide use at four university hospitals in southern Germany. Infection 30 (2002) 262-6.

Wagner D, Sangari FJ, Kim S, Petrofsky M, Bermudez LE. Mycobacterium avium infection of macrophages results in progressive suppression of interleukin-12 production in vitro and in vivo. J Leukoc Biol 71 (2002) 80-8.

Wellinghausen N, Pietzcker T, Kern WV, Essig A, Marre R. Expanded spectrum of Nocardia species causing clinical nocardiosis detected by molecular methods. Int J Med Microbiol 292 (2002) 277-82.

Wellinghausen N, Sing A, Kern WV, Perner S, Marre R, Rentschler J. A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans. Int J Med Microbiol 292 (2002) 59-63.