Welcome to the Aquatic Core Facility for Zebrafish and Xenopus research - AquaCore (RI_00544)
The mission of the Aquatic Core Facility (AquaCore) is to provide scientists with a state-of-the-art platform to conduct aquatic animal experiments (Xenopus laevis, Xenopus tropicalis, Danio rerio). Researchers are provided with infrastructure to experiment in accordance with EU and national legal requirements. Above all, the facility staff are implementing new strategies according to the ʻ3Rʼprinciple (reduce, replace, refine) in laboratory animal science.
AquaCore provides highest levels of care and expertise to aquatic animals used in research and teaching. The facility team supports scientists with expert advice and counseling in planning and realizing studies. AquaCore’s services include animal housing, microinjection and microscopy workstations, cryopreservation, and scientific training for aquatic animal science. The efficient use of shared research infrastructure optimizes the resources of the individual groups while maximizing the performance of the AquaCore facility.
The range of services offered includes animal housing and care, access to microinjection and microscopy workstations, cryopreservation, in vitro fertilization, Xenopus oocyte service, and wild-type animal breeding. These services are available upon request and require an active animal experimentation permit (Tiervesuchsantrag). Therefore, access is limited to researchers that have undergone an official training course according to the FELASA recommendations. Education and training is a key aspect of AquaCore's mission to support professional competence in personnel working with animals and the implementation of the 3Rs. Researchers that are keen to work with zebrafish or Xenopus need to be certified in Laboratory Animal Use according to the Federation of European Laboratory Animal Science Associations (FELASA) and courses are offered locally by AquaCore staff in cooperation with the University Freiburg Medical Faculty (TVA courses Freiburg).
For appointments, further information as well as the Terms of Use ("Nutzerordnung"), please contact the AquaCore team - We are happy to help!
Contact AquaCore:
Dr. Toma Yakulov (zebrafish) | Dr. Peter Walentek (Xenopus) |
Link to contact details Yakulov Lab | Link to contact details Walentek Lab |
Publications of the AquaCore Facility
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2023 Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation
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2022 MARVEL domain containing CMTM4 affects CXCR4 trafficking
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2022 Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury
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2022 Microridge-like structures anchor motile cilia
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2022 Clock genes rescue nphp mutations in zebrafish
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2022 Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling
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2022 Corpuscles of Stannius development requires FGF signaling
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2021 Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling
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2021 Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development
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2019 ΔN-Tp63 Mediates Wnt/β-Catenin-Induced Inhibition of Differentiation in Basal Stem Cells of Mucociliary Epithelia
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2018 CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
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2018 The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development
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2018 Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney
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2017 EpCAM controls morphogenetic programs during zebrafish pronephros development
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2016 Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors
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2016 ANKS3 is mutated in a family with autosomal recessive laterality defect
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2016 FAT1 mutations cause a glomerulotubular nephropathy
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2015 The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells
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2015 The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin
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2015 Anks3 interacts with nephronophthisis proteins and is required for normal renal development
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2014 Interaction with the Bardet-Biedl Gene Product TRIM32/BBS11 Modifies the Half-life and Localization of Glis2/NPHP7
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2013 A Complex of BBS1 and NPHP7 Is Required for Cilia Motility in Zebrafish
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2013 ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
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2011 Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish
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2010 Inversin relays Frizzled-8 signals to promote proximal pronephros development