Dr. Franziska Schneider-Warme
Head of Optogenetics, Emmy Noether Fellow
Contact
franziska.schneider.uhz@uniklinik-freiburg.de
+49 (0)761 270 63954
Research Interests:
- Design and implementation of new optogenetic tools for modulating the activity of excitable cells and tissues
- Development of optogenetic approaches for functionally dissecting electrical interactions between cardiac cell populations, with a current focus on cardiomyocytes, fibroblasts and resident immune cells
- Electrophysiological characterization of cardiac non-myocytes
- 3D reconstruction of cellular networks in healthy and diseased hearts
Brief CV:
Franziska Schneider-Warme studied Biophysics at the Humboldt University in Berlin (HUB) and at the Bordeaux Segalen University in Bordeaux (2004-2009). She then continued her post-graduate studies in the laboratory of Prof. Peter Hegemann at HUB, where her work focused on the design and optimization of rhodopsin-based optogenetic tools. After receiving her PhD in 2014, she completed a short post-doc working on a joint project with Christian Rosenmund's group at the Charité Berlin. In 2015, she joined Prof. Peter Kohl’s group at Imperial College London to apply the optogenetic approach to study heterocellular interactions in the heart. Since 2016 Franziska Schneider-Warme leads the Cardiac Optogenetics section at the IEKM in Freiburg, since November 2018 as an Emmy Noether Fellow.
Selected Publications:
- Fernández MC, Kopton RA, Simon-Chica A, Madl J, Hilgendorf I, Zgierski-Johnston CM, Schneider-Warme F. Channelrhodopsins for Cell-Type Specific Illumination of Cardiac Electrophysiology. Methods Mol Biol 2021/2191:287-307
- Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F. Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels. Cardiovasc Res 2021/cvab126
- Zgierski-Johnston CM, Schneider-Warme F. Observing and manipulating cell-specific cardiac function with light. Adv Exp Med Biol 2021/1293:377-388
- Kopton RA, Buchmann C, Moss R, Kohl P, Peyronnet R, Schneider-Warme F. Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity. J Vis Exp 2020/157
- Kopton RA [...] Moss R, Zgierski-Johnston CM [...] Kohl P, Quinn TA, Schneider-Warme F. Cardiac Electrophysiological Effects of Light-Activated Chloride Channels. Front Physiol 2018/9:1806
- Bernal Sierra YA*, Rost BR*, Pofahl M* [...] Kopton RA [...] Kohl P, Baier H, Schneider-Warme F [...] Schmitz D. Potassium channel-based optogenetic silencing. Nat Commun 2018/9:4611 (*equal contribution)
- Rost BR, Schneider-Warme F, Schmitz D, Hegemann P. Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron 2017/96:572-603
- Johnston CM, Rog-Zielinska EA, Wülfers EM [...] Kohl P, Schneider-Warme F. Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility. Prog Biophys Mol Biol 2017/130(Pt B):140-149
- Rost BR*, Schneider F* [...] Rosenmund C. Optogenetic Acidification of Synaptic Vesicles and Lysosomes. Nature Neuroscience 2015/18:1845–1852 (*equal contribution)
- Schneider F, Grimm C and Hegemann P. The biophysics of channelrhodopsin. Annual Review of Biophysics 2015/44:167-186
- Wietek J [...] Schneider F [...] Hegemann P. Conversion of Channelrhodopsin into a Light-Gated Chloride Channel. Science 2014/344:409-412
- Schneider F, Gradmann D and Hegemann P. Ion Selectivity and Competition in Channelrhodopsins. Biophysical Journal 2013/105:91-100
- Yizhar O, Fenno LE, Prigge M, Schneider F [...] and Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 2011/477:171-178