Ghosh, Avantika
Department of Thoracic Surgery – Division of Cancer Research, University Medical Center Freiburg
German Cancer Consortium (DKTK), Partner Site Freiburg
Breisacherstr. 115
79106 Freiburg i.Br.
avantika.ghosh@dkfz-heidelberg.de
Title of the project:
Systematic analysis of nonstop extension mutations in high throughput
Research in our group has shown that nonstop mutations are associated with cancer and are known to have a functional impact on protein expression and function. Our group has created the database NonStopDB, a comprehensive set of nonstop mutations in human cancer. In this project we aim to systematically analyse the functional impact of all non-stop extension mutations found somatically in human cancer in a pooled format using reporters and next generation sequencing.