The Institute for Surgical Pathology, University Medical Center Freiburg, Germany is offering
4 PhD positions for life scientists (m/f/d)
The research at the Institute for Surgical Pathology is highly interdisciplinary and has a strong focus on translational research in oncology and nephrology. In addition, research includes cutting-edge methodological developments in the areas of shotgun proteomics, spatial proteomics and metabolomics, organotypic in vitro cultures and artificial intelligence for image analysis.
We offer 4 PhD positions in the following areas:
1 Role of matrisomal biology for heterocellular crosstalk in kidney cancer - Prof. Christoph Schell
This position uses multiplex immunostaining, organotypic tissue slice cultures and CRISPR/Cas9 modified cellular models to dissect the role of matrisomal biology in modulating heterocellular crosstalk in the tumor microenvironment of renal cell carcinoma.
This position uses multiplex immunostaining, organotypic tissue slice cultures and CRISPR/Cas9 modified cellular models to dissect the role of matrisomal biology in modulating heterocellular crosstalk in the tumor microenvironment of renal cell carcinoma.
2 Spatial profiling of kidney cancer - Prof. Oliver Schilling
This position includes technical developments in the areas of mass spectrometry based spatial proteomics (LC-MS/MS and MALDI imaging) as well as degradomic approaches in the context of kidney cancer.
This position includes technical developments in the areas of mass spectrometry based spatial proteomics (LC-MS/MS and MALDI imaging) as well as degradomic approaches in the context of kidney cancer.
3 Spatial multi-omics and organotypic cultures of bile duct cancer - Dr. Melanie Föll
This position combines spatial metabolomics by MALDI imaging with spatial proteomics by LC-MS/MS applied to bile duct cancer and follow up on novel therapeutic approaches using in vitro organotypic tissue slice cultures.
This position combines spatial metabolomics by MALDI imaging with spatial proteomics by LC-MS/MS applied to bile duct cancer and follow up on novel therapeutic approaches using in vitro organotypic tissue slice cultures.
4 Proteomics based personalized medicine for glioblastoma - Prof. Oliver Schilling
This position develops and applies high-throughput shotgun proteomics to identify novel therapeutic targets and stratify glioblastoma patients for personalized therapies.
The laboratories of Prof. Schell, Prof. Schilling and Dr. Föll work closely together and offer a friendly and supportive work environment with extensive in-house and external training for scientific and professional development. We offer modern and well-equipped laboratories including cutting edge mass spectrometry instrumentation (timsTOF fleX). Our interdisciplinary groups work in close exchange with local and international partners. All projects provide ample opportunities for scientific publishing and conference participation.
Required qualifications include a MSc or diploma degree or similar in a life sciences discipline (e.g. biology, biochemistry, molecular medicine, pharmacy) and very good communication skills in English (written and spoken). The ideal candidate should have experience in one or more of the following areas: mass spectrometry (LC-MS/MS / MALDI-TOF), cell/tissue/organoid culture techniques, immunostaining, and basic programming skills (R, python). We expect willingness to acquire competences in these fields as needed for the respective PhD position. Thus, an open-minded, proactive and cooperative work attitude with excellent problem-solving and organizational skills are essential.
All positions are according to TV-L (65 %), with a starting date between January and April. The duration of the positions is 3 to 4 years.
Please apply through the UNIKLINIK SYSTEM and include the names of 1-2 referees in your application and clearly state in which positions (number 1 to 4) you are interested in.
Contacts for further inquiries:
Prof. Oliver Schilling
oliver.schilling@uniklinik-freiburg.de
Prof. Christoph Schell
christoph.schell@uniklinik-freiburg.de
Dr. Melanie Föll
melanie.foell@uniklinik-freiburg.de